Patents by Inventor Sarkis Mazmanian

Sarkis Mazmanian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of microbially induced amyloid
    Patent number: 11744820
    Abstract: The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: September 5, 2023
    Assignees: Axial Therapeutics, Inc., California Institute of Technology
    Inventors: Timothy Sampson, Sarkis Mazmanian, Anthony Stewart Campbell
  • INHIBITORS OF MICROBIALLY INDUCED AMYLOID
    Publication number: 20220040145
    Abstract: The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.
    Type: Application
    Filed: September 8, 2021
    Publication date: February 10, 2022
    Inventors: Timothy Sampson, Sarkis Mazmanian, Anthony Stewart Campbell
  • Inhibitors of microbially induced amyloid
    Patent number: 11147792
    Abstract: The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: October 19, 2021
    Assignees: AXIAL THERAPEUTICS, INC., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Timothy Sampson, Sarkis Mazmanian, Anthony Stewart Campbell
  • METHODS AND APPARATUS FOR DETERMINING RISK OF AUTISM SPECTRUM DISORDER
    Publication number: 20210317508
    Abstract: Aspects of the invention described herein relate to bacteria and metabolites, which may be used in diagnostics, therapeutics and/or dietary supplements so as to identify the risk to an individual of developing ASD or ASD-like disorders, as well as, to inhibit, treat, and/or prevent the onset of ASD and/or and ASD-like disorders.
    Type: Application
    Filed: July 30, 2018
    Publication date: October 14, 2021
    Inventors: Gil SHARON, Sarkis MAZMANIAN, Ryan BARRETT, Anthony Stewart CAMPBELL
  • INHIBITORS OF MICROBIALLY INDUCED AMYLOID
    Publication number: 20200163933
    Abstract: The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.
    Type: Application
    Filed: May 14, 2018
    Publication date: May 28, 2020
    Inventors: Timothy Sampson, Sarkis Mazmanian, Anthony Stewart Campbell
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20130039949
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: May 4, 2012
    Publication date: February 14, 2013
    Inventors: Sarkis MAZMANIAN, June L. ROUND, Ryan Michael O'CONNELL, Dennis L. KASPER
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20110002965
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 6, 2011
    Inventors: June L. Round, Sarkis Mazmanian, Ryan Michael O'Connell, Dennis L. Kasper
  • IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20090124573
    Abstract: Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for treating or preventing an inflammatory condition associated with an imbalance of a T-helper cell profile.
    Type: Application
    Filed: November 9, 2008
    Publication date: May 14, 2009
    Inventors: SARKIS MAZMANIAN, JUNE L. ROUND, RYAN MICHAEL O'CONNELL, DENNIS L. KASPER
  • Identification of sortase gene
    Patent number: 7238489
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: July 3, 2007
    Assignee: The Regents of the University of California
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Methods and compositions involving sortase B
    Publication number: 20060073530
    Abstract: The present invention provides methods and compositions involving sortase-transamidases, including sortase B, and polypeptides that include a signal sorting sequence of NPQ/KTN/G. Methods of screening for inhibitors of Gram-positive bacteria as well as therapeutic, preventative, and research methods focusing on Gram-positive bacteria are also provided.
    Type: Application
    Filed: August 15, 2002
    Publication date: April 6, 2006
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Kenneth Su, Hung Ton-That
  • Identification of sortase gene
    Publication number: 20050069984
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Application
    Filed: October 18, 2004
    Publication date: March 31, 2005
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Identification of sortase gene
    Patent number: 6773706
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: August 10, 2004
    Assignee: The Regents of the University of California
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Identification of sortase gene
    Publication number: 20030022178
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Application
    Filed: August 21, 2001
    Publication date: January 30, 2003
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That