Abstract: Systems, methods and computer readable media are provided that facilitate monitoring and evaluating patient reactions to medications. In an embodiment, a method can include receiving, by a system comprising a processor, reaction information regarding one or more reactions experienced by a patient in association with usage of a medication by the patient, and generating, by the system, a reaction log for the patient comprising the information. The method can further comprise, providing, by the system, one or more authorized users access to the reaction log, and evaluating, by the system, the reaction information to determine whether the reaction information indicates the patient is experiencing or has experienced one or more clinically significant reactions to the medication.