Abstract: The anti-quorum and DNA cleaving agent is directed to a ruthenium complex formulated from dichloro-(?6-p-cymene) ruthenium(II) dimer and 2-chloroquinoxaline, the complex having the formula: The reaction cleaves the dimer, leaving a half-sandwich ruthenium complex with an ?6 coordination bond to the arene ligand and an Ru—N bond attaching the chloroquinoxaline to the ruthenium complex. The agent has an anti-quorum sensing effect on bacteria, inhibiting the formation of biofilm and inhibiting bacterial virulence. The agent also binds to DNA and may cleave the DNA, e.g., at the N7 base pair of guanine, due to a hydrolytic mechanism, suggesting potential use as an anticancer or antitumor agent.

Abstract: The combination microarray patch for drug delivery and electrochemotherapy device is a medical device for delivering two separate pharmaceutical preparations to a patient, as well as providing electrostimulation for electroactive pharmaceuticals. A first pharmaceutical preparation is manually delivered into the patient through a first set of drug delivery needles. Similarly, a second pharmaceutical preparation is manually delivered into a patient through a second set of drug delivery needles. A desired electrical potential may then be selectively applied across first and second sets of electrotherapy needles for electroporation to facilitate delivery of the pharmaceutical preparations. The second pharmaceutical preparation may be a conjugate of the first for targeted drug delivery.