Patents by Inventor Sasa Koncarevic

Sasa Koncarevic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isotopic methods for measurement of tryptophan and metabolites thereof
    Patent number: 11320438
    Abstract: Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: May 3, 2022
    Assignees: ELECTROPHORETICS LIMITED, RUPRECHT-KARLS-UNIVERSITAT, DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Sasa Koncarevic, Karsten Kuhn, Peter Schulz-Knappe, Ian Hugo Pike, Christiane Opitz, Michael Platten
  • ISOTOPIC METHODS FOR MEASUREMENT OF TRYPTOPHAN AND METABOLITES THEREOF
    Publication number: 20180246118
    Abstract: Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.
    Type: Application
    Filed: October 31, 2016
    Publication date: August 30, 2018
    Applicants: ELECTROPHORETICS LIMITED, RUPRECHT-KARLS-UNIVERSITÄT, DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Sasa Koncarevic, Karsten Kuhn, Peter Schulz-Knappe, Ian Hugo Pike, Christiane Opitz, Michael Platten
  • MATERIALS AND METHODS FOR DETERMINING SENSITIVITY POTENTIAL OF COMPOUNDS
    Publication number: 20140242599
    Abstract: The invention concerns in vitro proteomic analysis of cells to determine the sensitizing potential (including allergic potential) of compounds on said cells. Several protein markers are provided that allow assays to be performed to determine whether a chemical has a sensitizing potential of contact sensitizers.
    Type: Application
    Filed: August 10, 2012
    Publication date: August 28, 2014
    Applicant: ELECTROPHORETICS LIMITED
    Inventors: Petra Budde, Hans-Dieter Zucht, Stefan Selzer, Sasa Koncarevic, Karsten Kuhn, Ian Pike, Stephan Jung
  • MATERIALS AND METHODS FOR DETERMINING SENSITIVITY POTENTIAL OF COMPOUNDS
    Publication number: 20140220566
    Abstract: The invention concerns in vitro proteomic analysis of cells to determine the sensitizing potential (including allergic potential) of compounds on said cells. Several protein markers are provided that allow assays to be performed to determine whether a chemical has a sensitizing potential of contact and/or respiratory sensitizers.
    Type: Application
    Filed: June 18, 2012
    Publication date: August 7, 2014
    Applicant: ELECTROPHORETICS LIMITED
    Inventors: Emma Lahert, Stephan Jung, Petra Budde, Hans-Dieter Zucht, Stefan Selzer, Sasa Koncarevic, Karsten Kuhn, Ian Pike