Patents by Inventor Sasan Jalili-Firoozinezhad

Sasan Jalili-Firoozinezhad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complex Human Gut Microbiome Cultured In An Anaerobic Human Gut-On-A-Chip
    Publication number: 20240002808
    Abstract: A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.
    Type: Application
    Filed: July 25, 2023
    Publication date: January 4, 2024
    Inventors: Richard Novak, Sasan Jalili-Firoozinezhad, Francesca S. Gazzaniga, Elizabeth Calamari, Diogo M. Camacho, Bret Andrew Nestor, Cicely Fadel, Michael J. Cronce, Dennis Kasper, Donald E. Ingber, Amir Bein
  • Complex human gut microbiome cultured in an anaerobic human gut-on-a-chip
    Patent number: 11807871
    Abstract: A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: November 7, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Richard Novak, Sasan Jalili-Firoozinezhad, Francesca S. Gazzaniga, Elizabeth L. Calamari, Diogo M. Camacho, Bret A. Nestor, Cicely Fadel, Michael L. Cronce, Dennis L. Kasper, Donald E. Ingber, Amir Bein
  • Complex Human Gut Microbiome Cultured In An Anaerobic Human Gut-On-A-Chip
    Publication number: 20210079356
    Abstract: A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.
    Type: Application
    Filed: April 2, 2019
    Publication date: March 18, 2021
    Inventors: Richard Novak, Sasan Jalili-Firoozinezhad, Francesca S. Gazzaniga, Elizabeth L. Calamari, Diogo M. Camacho, Bret A. Nestor, Cicely Fadel, Michael L. Cronce, Dennis L. Kasper, Donald E. Ingber, Amir Bein