Patents by Inventor Sascha Doekel

Sascha Doekel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080051326
    Abstract: The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: November 11, 2005
    Publication date: February 28, 2008
    Inventors: Dylan Alexander, Richard Baltz, Paul Brian, Marie-Francoise Coeffet-Le Gal, Sascha Doekel, Xiaowei He, Vidya Kulkarni, Christopher Leitheiser, Vivian Pak Woon Miao, Kien Trung Nguyen, Ian Barrie Parr, Daniel Ritz, Yanzhi Zhang
  • Publication number: 20020064834
    Abstract: The present invention relates to a new, microbiological, method for the production of &agr;-L-aspartyl-L-phenylalanine (Asp-Phe) from the substrates L-aspartic acid (L-Asp) and L-phenylalanine (L-Phe) wherein the substrates are contacted, in the presence of ATP, with a non-ribosomal dipeptide synthetase comprising two minimal modules connected by one condensation domain wherein the N- resp. C-terminal modules are recognizing L-Asp and L-Phe, respectively, and the latter module is covalently bound at its N-terminal end to the condensation domain, and wherein each of these minimal modules is composed of an adenylation domain and a 4′-phosphopantetheinyl cofactor containing thiolation domain, and that the Asp-Phe formed is recovered. The present invention also relates to novel DNA fragments or combination of DNA fragments encoding a new Asp-Phe dipeptide synthetase, micro-organisms containing such DNA fragments, as well as to the new Asp-Phe dipeptide synthetases itself.
    Type: Application
    Filed: October 1, 2001
    Publication date: May 30, 2002
    Inventors: Sascha Doekel, Mohamed A. Marahiel, Peter J.L.M. Quaedflieg, Theodorus Sonke