Abstract: The present invention provides a method for detecting structural variations (SV) within genomes of single cells or population of single cells by integrating a three-layered information of sequencing read depth, read strand orientation and haplotype phase. The method of the invention can detect deletions, duplications, polyploidies, translocations, inversions, and copy number neutral loss of heterozygosity (CNN-LOH), and more. The method of the invention can fully karyotype a genome comprehensively, and may be applied in research and clinical approaches. For example, the methods of the invention are useful for analysing cellular samples of patients for diagnosing or aiding a diagnosis, in reproductive medicine to detect embryonic abnormalities, or during therapeutic approaches based on cellular therapies to quality control genetically engineered cells, such as in adoptive T cell therapy and others.

Abstract: A bent-back plug-type connector for coaxial cables includes a bent-back outer conductor having a first conductor section which extends along a plug axis and a second conductor section which adjoins the first conductor section and is arranged at an angle with respect thereto, as well as a first inner conductor, which is arranged concentrically and insulated in the first conductor section, and a second inner conductor, which is arranged concentrically and insulated in the second conductor section and is detachably connected to the first inner conductor in the corner region of the bent-back outer conductor. With such a plug-type connector, simpler fitting, a secure and permanent connection and simpler and more cost-effective production are achieved by virtue of the fact that the first inner conductor has a square cross section, and the fact that an opening is provided in the first inner conductor.