Patents by Inventor Sascha Weidler

Sascha Weidler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTITARGETING BISPECIFIC ANTIGEN-BINDING MOLECULES OF INCREASED SELECTIVITY
    Publication number: 20240209078
    Abstract: The present invention provides multitargeting bispecific antigen-binding molecules characterized by comprising a first and a second bispecific entity each comprising a domain binding to target, a second domain binding to an extracellular epitope of the human and the Macaca CD3? chain, wherein both bispecific entities are linked to each other by a spacer which spaces apart the first and the second bispecific entity. Moreover, the invention provides a polynucleotide, encoding the multitargeting bispecific antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
    Type: Application
    Filed: November 8, 2021
    Publication date: June 27, 2024
    Inventors: Stephanie Everts, Matthias Klinger, Virginie Naegele, Adam Zalewski, Claudia Blümel, Thomas Boehm, Johannes Brozy, Igor D'Angelo, Peter Kufer, Petra Lutterbüse, Markus Muenz, Doris Rau, Tobias Raum, Benno Rattel, Oliver Thomas, Ines Ullrich, Joachim Wahl, Christian Webhofer, Sascha Weidler, Elizabeth Dang Pham, Julie Bailis
  • Inhibition of the proliferation of cells of the multiple myeloma
    Patent number: 7078478
    Abstract: Multiple myeloma is treated by deletion mutants of the gp130 protein of the IL-3 receptor. These mutants inhibit the binding of Hck tyrosine kinase and the growth of tumor cells, particularly myeloma cells.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: July 18, 2006
    Assignee: GSF-Forschungszentrum für Umwelt Gesundheit, GmbH
    Inventors: Michael Schaeffer, Michaela Schneiderbauer, Sascha Weidler, Michael Hallek
  • Deletion of the Hck binding region in the IL-6 receptor
    Patent number: 6605703
    Abstract: The present invention describes a means for the treatment of multiple myeloma. Deletion mutants of the gp130 protein of the IL-3 receptor are presented which inhibit the binding of Hck tyrosine kinase and the growth of tumor cells, particularly of myeloma cells.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: August 12, 2003
    Assignee: GSF—Forschungszentrum fur Umwelt und Gesundheit GmbH
    Inventors: Michael Schaeffer, Michaela Schneiderbauer, Sascha Weidler, Michael Hallek
  • Inhibition of the proliferation of cells of the multiple myeloma
    Publication number: 20030105287
    Abstract: Multiple myeloma is treated by deletion mutants of the gp130 protein of the IL-3 receptor. These mutants inhibit the binding of Hck tyrosine kinase and the growth of tumor cells, particularly myeloma cells.
    Type: Application
    Filed: July 12, 2002
    Publication date: June 5, 2003
    Applicant: GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH
    Inventors: Michael Schaeffer, Michaela Schneiderbauer, Sascha Weidler, Michael Hallek