Abstract: Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.

Abstract: The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols.

Abstract: Methods for modulating gene expression in a skin cell by administering to the cell an amount of a therapeutic composition in an amount sufficient to modulate the expression of miR-1, and therapeutic compositions and uses thereof are disclosed.

Abstract: An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).

Abstract: An agent for treating strokes in humans is tested in a non-human subject by selecting an agent for testing and by preparing a selected non-human subject. The preparation includes: inducing a stroke event by advancing a microwire through the arterial system of the subject to a selected intracranial target position, inserting a microcatheter along the microwire and delivering an embolic device to the target position, occluding the artery at the target position by deploying the embolic device, verifying the occlusion and repositioning the embolic device if needed. After a predetermined occlusion interval, reperfusion of the subject is simulated by removing the embolic device and commencing therapy with the selected agent. At appropriate intervals, the effect of the conducted course of therapy is assessed non-invasively until terminal evaluation. In particular aspects, the method involves occluding the middle cerebral artery through an access achieved via the basilar artery.

Abstract: The invention provides methods, delivery devices, and compositions for topically oxygenating hypoxic tissue with a hemoglobin-based oxygen earner (HBOC), such as Oxyglobin (Oxyb) in order to promote wound healing and/or reducing hypoxia in post-harvest transplant tissue. The invention can be used, among other things, to stimulate angiogenesis and blood flow at a wound site, reduce wound dilation, and promote wound contraction, thereby increasing the overall rate of wound healing. The invention can also be used, among other things, to reduce oxidative stress in pre-implantation donor organ tissue, as well as stimulate the proliferation of granulation tissue, vessel growth, and promote epithelial healing in transplant tissue once it has been implanted.

Abstract: An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).

Abstract: Therapeutic and prophylactic agents comprising tocotrienols, and methods of using the same are provided for the treatment of and the prevention of the onset of stroke and other disorders and diseases associated with elevated glutamate levels, and the effects of lipoxygenases such as the enzyme 12-lipoxygenase.

Abstract: A compound is provided having the formula I: wherein the variables are defined in the specification. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided.

Abstract: A compound is provided having the formula I: 1

Abstract: A compound is provided having the formula I: as defined in the specification. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided.

Abstract: A compound is provided having the formula I: ##STR1## wherein R.sup.1 and R.sup.2 independently denote a methylene, ethylene or unbranched or branched C.sub.3-16 alkylene, alkenylene or alkynylene group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in the unbranched or branched C.sub.3-16 alkylene, alkenylene or alkynylene group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom,R.sup.3 and R.sup.4(i) independently denote(a) hydrogen,(b) a methyl, ethyl, vinyl or unbranched or branched C.sub.3-16 alkyl, alkenyl or alkynyl group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in said unbranched or branched C.sub.