Patents by Inventor Saskia Anne-Marie Jenny Lesnik Oberstein

Saskia Anne-Marie Jenny Lesnik Oberstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL
    Patent number: 9353169
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 mRNA or pre-mRNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 mRNA or pre-mRNA.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: May 31, 2016
    Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse
  • MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL
    Publication number: 20150274796
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain.
    Type: Application
    Filed: June 12, 2015
    Publication date: October 1, 2015
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse
  • Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL
    Patent number: 9062311
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: June 23, 2015
    Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse
  • MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL
    Publication number: 20110318787
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA.
    Type: Application
    Filed: January 26, 2010
    Publication date: December 29, 2011
    Applicant: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse