Patents by Inventor Sassan Sheikholeslami

Sassan Sheikholeslami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOADING NUCLEIC ACIDS ONTO SUBSTRATES
    Publication number: 20230405544
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Application
    Filed: March 22, 2023
    Publication date: December 21, 2023
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula, Michael W. Hunkapiller, Erik Miller, Satwik Kamtekar
  • Loading nucleic acids onto substrates
    Patent number: 11642643
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 9, 2023
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
  • Methods and compositions for loading of polymerase complexes
    Patent number: 11578364
    Abstract: The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions. In particular, the described methods, compositions, and systems utilize density differentials and/or additives to increase efficiency in the distribution of polymerase compositions to a surface as compared to methods utilizing only diffusion control.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: February 14, 2023
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Sassan Sheikholeslami, Michael W. Hunkapiller, Natasha Popovich, Lei Sun, Erik Miller, Satwik Kamtekar
  • METHODS AND COMPOSITIONS FOR ISOLATING ASYMMETRIC NUCLEIC ACID COMPLEXES
    Publication number: 20210207190
    Abstract: The present disclosure provides improved methods for isolating asymmetrically-primed and/or asymmetrically-tagged nucleic acid complexes that find use in downstream analytical analyses, including sequence analysis. Compositions comprising such complexes and kits and systems for generating such complexes are also provided.
    Type: Application
    Filed: January 15, 2021
    Publication date: July 8, 2021
    Inventors: Lei Sun, Sassan Sheikholeslami, Natasha Popovich, David Christopher Scherer
  • LOADING NUCLEIC ACIDS ONTO SUBSTRATES
    Publication number: 20210069664
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 11, 2021
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
  • Methods and compositions for isolating asymmetric nucleic acid complexes
    Patent number: 10920268
    Abstract: The present disclosure provides improved methods for isolating asymmetrically-primed and/or asymmetrically-tagged nucleic acid complexes that find use in downstream analytical analyses, including sequence analysis. Compositions comprising such complexes and kits and systems for generating such complexes are also provided.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: February 16, 2021
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lei Sun, Sassan Sheikholeslami, Natasha Popovich, David Christopher Scherer
  • METHODS AND COMPOSITIONS FOR LOADING OF POLYMERASE COMPLEXES
    Publication number: 20200385802
    Abstract: The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions. In particular, the described methods, compositions, and systems utilize density differentials and/or additives to increase efficiency in the distribution of polymerase compositions to a surface as compared to methods utilizing only diffusion control.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 10, 2020
    Inventors: Sassan Sheikholeslami, Michael Hunkapiller, Natasha Popovich, Lei Sun, Erik Miller, Satwik Kamtekar
  • Loading nucleic acids onto substrates
    Patent number: 10814299
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: October 27, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
  • Methods and compositions for loading of polymerase complexes
    Patent number: 10731211
    Abstract: The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions. In particular, the described methods, compositions, and systems utilize density differentials and/or additives to increase efficiency in the distribution of polymerase compositions to a surface as compared to methods utilizing only diffusion control.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: August 4, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Sassan Sheikholeslami, Michael Hunkapiller, Natasha Popovich, Lei Sun, Erik Miller, Satwik Kamtekar
  • METHODS AND COMPOSITIONS FOR ISOLATING ASYMMETRIC NUCLEIC ACID COMPLEXES
    Publication number: 20190024140
    Abstract: The present disclosure provides improved methods for isolating asymmetrically-primed and/or asymmetrically-tagged nucleic acid complexes that find use in downstream analytical analyses, including sequence analysis. Compositions comprising such complexes and kits and systems for generating such complexes are also provided.
    Type: Application
    Filed: July 16, 2018
    Publication date: January 24, 2019
    Inventors: Lei Sun, Sassan Sheikholeslami, Natasha Popovich, David Christopher Scherer
  • METHODS AND COMPOSITIONS FOR LOADING OF POLYMERASE COMPLEXES
    Publication number: 20170159119
    Abstract: The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions. In particular, the described methods, compositions, and systems utilize density differentials and/or additives to increase efficiency in the distribution of polymerase compositions to a surface as compared to methods utilizing only diffusion control.
    Type: Application
    Filed: November 17, 2016
    Publication date: June 8, 2017
    Inventors: Sassan SHEIKHOLESLAMI, Michael HUNKAPILLER, Natasha POPOVICH, Lei SUN, Erik MILLER, Satwik KAMTEKAR
  • LOADING NUCLEIC ACIDS ONTO SUBSTRATES
    Publication number: 20170136433
    Abstract: Methods, compositions, and systems for distributing nucleic acids into array regions are provided. The methods, compositions, and systems utilize nucleic acid condensing agents to increase efficiency of distribution of the nucleic acids into the array regions. Various methods for facilitating distribution of the nucleic acids to the array regions are provided.
    Type: Application
    Filed: November 17, 2016
    Publication date: May 18, 2017
    Inventors: Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula, Yufeng Qian