Patents by Inventor Saswati Chatterjee

Saswati Chatterjee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prevention And Treatment Of Vascular Disease With Recombinant Adeno-Associated Virus Vectors Encoding Apolipoprotein A-I And Apolipoprotein A-I Milano
    Publication number: 20070202081
    Abstract: Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in the prevention and treatment of atherosclerosis, as well as any disease or physiological condition in which atherosclerosis plays a role. The inventive methods involve the gene delivery of ApoA-I or ApoA-IMilano. This may be accomplished by the use of rAAV technology. rAAV virions may be delivered to a mammalian subject by various methodologies, including transplantation of transduced bone marrow cells, direct intramuscular injection, intravenous or portal vein injection or stent delivery.
    Type: Application
    Filed: April 5, 2005
    Publication date: August 30, 2007
    Applicants: CEDARS-SINAI MEDICAL CENTER, CITY OF HOPE
    Inventors: Prediman Shah, Saswati Chatterjee, Kamehameha Wong
  • AAV2 Rep protein fusions
    Patent number: 7122348
    Abstract: This invention pertains to methods for promoting stable and site-specific integration of rep deleted recombinant adeno-associated virus vectors which result in less variable transgene expression and increased safety. These vectors are useful for delivery of a functional gene product to the desired intracellular location.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: October 17, 2006
    Assignee: City of Hope
    Inventors: Kamehameha Kay-Min Wong, Jr., Saswati Chatterjee, Joel Conrad, Stella Kim
  • Method of genetically modifying very primitive quiescent human hematopoietic stem cells
    Patent number: 6919209
    Abstract: This invention relates to a method for transducing extremely primitive hematopoietic stem cells with high efficiency, using an adeno-associated vector. This vector stably transforms highly primitive CD34+++CD38= cells which reside in a quiescent state and retain to a larger extent the ability to repopulate the hematopoietic system.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: July 19, 2005
    Assignee: City of Hope
    Inventors: Saswati Chatterjee, Kamehameha K. Wong, Jr., Christie Wong, Grace Fisher-Adams
  • AAV2 Rep protein fusions
    Publication number: 20050003344
    Abstract: This invention pertains to methods for promoting stable and site-specific integration of rep deleted recombinant adeno-associated virus vectors which result in less variable transgene expression and increased safety. These vectors are useful for delivery of a functional gene product to the desired intracellular location.
    Type: Application
    Filed: December 11, 2003
    Publication date: January 6, 2005
    Applicant: City of Hope
    Inventors: Kamehameha Wong, Saswati Chatterjee, Joel Conrad, Stella Kim
  • Adeno-associated virus (AAV)-based eucaryotic vectors
    Patent number: 5474935
    Abstract: The present invention relates to adeno-associated virus (AAV)-based eucaryotic vectors and uses thereof. Such vectors may, for example, be used to down regulate any targeted viral or cellular gene whose sequence is known. Furthermore, the vectors may also be used to cause the expression of proteins.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: December 12, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Saswati Chatterjee, K. K. Wong, Jr.