Patents by Inventor Satchandra Kiran Divi

Satchandra Kiran Divi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC PROCESS FOR THE PREPARATION OF (2S)-2-[(4R)-2-OXO-4-PROPYL-PYRROLIDIN-1-YL]BUTYRIC ACID AND ITS CONVERSION INTO BRIVARACETAM
    Publication number: 20220241242
    Abstract: A process for the preparation of Brivaracetam, an anti-convulsion drug, is provided comprising enzymatic conversion of (2RS)-2-[ (4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butyric acid methyl ester selectively into (2S)-2-[ (4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butyric acid having high chiral purity, using protease from Bacillus licheniformis. Converting the chirally pure acid into an amide results in Brivaracetam.
    Type: Application
    Filed: February 24, 2021
    Publication date: August 4, 2022
    Inventors: Satchandra Kiran Divi, Mysore AswathaNarayana Rao, Shaik Nowshuddin
  • Enzymatic process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl]butyric acid and its conversion into brivaracetam
    Patent number: 11400074
    Abstract: A process for the preparation of Brivaracetam, an anti-convulsion drug, is provided comprising enzymatic conversion of (2RS)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butyric acid methyl ester selectively into (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl] butyric acid having high chiral purity, using protease from Bacillus licheniformis. Converting the chirally pure acid into amide results in Brivaracetam.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: August 2, 2022
    Assignee: Divi's Laboratories Ltd.
    Inventors: Satchandra Kiran Divi, Mysore Aswathanarayana Rao, Shaik Nowshuddin
  • Process for the preparation of gabapentin
    Patent number: 10399926
    Abstract: The present invention relates to an improved process for the preparation of Gabapentin. The process also relates to a new process for the preparation of 1, 1-cyclohexane diaceitic acid monoamide (CDMA), which is a key intermediate for the preparation of Gabapentin.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: September 3, 2019
    Assignee: Divi's Laboratories Ltd.
    Inventors: Satchandra Kiran Divi, Mysore AswathaNarayana Rao, Surendra Kalyan Nuthi
  • Process for the preparation of Droxidopa
    Patent number: 9920342
    Abstract: A novel process for the preparation of L-threo-dihydroxyphenylserine (Droxidopa) is described. It comprises of enantioselective hydrolysis of racemic (DL)-threo-N-acetyl-3-(3,4-methylenedioxyphenyl)-serine using commercially available L-amino acylase from Aspergillus sp. (EC 3.5.1.14) in the presence of cobalt ions, to obtain (L)-threo-3-(3,4-methylenedioxyphenyl)-serine followed by dealkylation to obtain Droxidopa. Protecting the amino group of (L)-threo-3-(3,4-methylenedioxyphenyl)-serine using either benzyloxycarbonyl or phthaloyl group before dealkylation followed by deprotection of the amino group results in obtaining Droxidopa in high yields and purity.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: March 20, 2018
    Inventors: Satchandra Kiran Divi, Mysore Aswatha Narayana Rao, Ponnekanti Purnachandra Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF DROXIDOPA
    Publication number: 20170335357
    Abstract: A novel process for the preparation of L-threo-dihydroxyphenylserine (Droxidopa) is described. It comprises of enantioselective hydrolysis of racemic (DL)-threo-N-acetyl-3-(3,4-methylenedioxyphenyl)-serine using commercially available L-amino acylase from Aspergillus sp. (EC 3.5.1.14) in the presence of cobalt ions, to obtain (L)-threo-3-(3,4-methylenedioxyphenyl)-serine followed by dealkylation to obtain Droxidopa. Protecting the amino group of (L)-threo-3-(3,4-methylenedioxyphenyl)-serine using either benzyloxycarbonyl or phthaloyl group before dealkylation followed by deprotection of the amino group results in obtaining Droxidopa in high yields and purity.
    Type: Application
    Filed: January 24, 2017
    Publication date: November 23, 2017
    Inventors: Satchandra Kiran Divi, Mysore Aswatha Narayana Rao, Ponnekanti Purnachandra Rao, Shaik Nowshuddin
  • Process for the preparation of lacosamide
    Patent number: 9447024
    Abstract: A novel process for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (Lacosamide) is described. It comprises reacting N-acetyl-D-serine methyl ester with benzylamine catalyzed by a non-nucleophilic base to obtain (R)-2-acetamido-2-N-benzyl-3-hydroxy propionamide followed by its methylation.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 20, 2016
    Assignee: Divi's Laboratories Limited
    Inventors: Satchandra Kiran Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin