Abstract: This disclosure described the role of AMPK in circadian rhythms and methods of screening for agents that modulate such rhythms, compositions that are useful for modulating such rhythms and uses thereof.

Abstract: Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.

Abstract: Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.

Abstract: The present invention provides a transgenic non-human animals comprising a disruption in the melanopsin gene as well as methods for using the animals to identify agents useful for modulating circadian rhythm in animals.

Abstract: A method and apparatus for performing harmonic imaging. Each transmit focal zone in the near-field is interrogated by two or more transmit firings of different phase, while each transmit focal zone in the far-field is interrogated by a single transmit firing. On receive, the respective near-field vectors are summed, thereby substantially canceling the fundamental signal components while isolating the (sub)-harmonic signal components. In the far-field, the single transmit firing has a fundamental frequency .function..sub.0. A filter isolates the signal component having a passband centered at a (sub)harmonic frequency, e.g., 2.function..sub.0. The near-field and far-field receive vectors at each scan angle are then stitched together to form a composite vector.

Abstract: An adaptive transducer array in which the element pitch is controlled by the imaging system depending on the mode of operation. A multiplicity of transducer elements are connected to a multiplicity of beamformer channels by a multiplexing arrangement having multiple states. In one multiplexer state, successive transducer elements are respectively connected to successive beamformer channels to produce an aperture having a small element pitch equal to the distance separating the centerlines of two adjacent transducer elements. In another multiplexer state, selected transducer elements are respectively connected to successive beamformer channels to produce an aperture having an increased element pitch equal to the small pitch multiplied by a factor of two or more. The aperture is increased by connecting together pairs of adjacent elements to a respective beamformer channel or by connecting every other element to a respective beamformer channel to form a sparse array.