Abstract: A device for preventing or reducing the incidence or intensity of pain occurring in a region of the body of a wearer, includes insulating material (2) which is arranged to be worn in conformity and close proximity with the body region. The insulating material has at least one layer (14) for reducing heat loss from the body region by convection and at least one reflective layer (13) for reducing heat loss from the body by radiation, whereby a targeted local warming effect is achieved in the body region such that the skin and underlying musculoskeletal structures are in such an active state that they can function properly to provide a clinical benefit to the body region.

Abstract: An assay technique for qualitative and quantitative detection of a chemical, biochemical or biological detection of a chemical, biochemical or biological species in sample. The technique comprises: (a) coating at least a predetermined part of a pre-formed surface on a substrate with a thin film of a material capable of binding the species to be assayed, the pre-formed surface being optically active with respect to radiation at least over a predetermined band of wavelengths; (b) contacting the coated surface with sample; and (c) observing the optical properties of said pre-formed surface in order to determine a qualitative and quantitative change in optical properties as a result of the binding of the species onto said thin film of material. The optical properties as a result of the pre-formed surface may be observed before and after step (b) in order to determine any change in optical properties, or they may be monitored during step (b). The pre-formed surface is preferably a grating.

Abstract: An assay technique for qualitative and quantitative detection of a chemcial, biochemical or biological detection of a chemical, biochemical or biological species in sample. The technique comprises (a) coating at least a predetermined part of a pre-formed surface on a substrate with a thin film of a material capable of binding the species to be assayed, the pre-formed surface being optically active with respect to radiation at least over a predetermined band of wavelengths; (b) contacting the coated surface with sample; and (c) observing the optical properties of said pre-formed surface in order to determine a qualitative and quantitative change in optical properties as a result of the binding of the species onto said thin film of material. The optical properties of the pre-formed surface may be observed before and after step (b) in order to determine any change in optical properties, or they may be monitored during step (b). The pre-formed surface is preferably a grating.

Abstract: An assay technique for the qualitative and/or quantitative detection of a chemical, biochemical or biological species in a sample comprising (a) coating at least a predetermined part of a pre-formed surface with a thin film of a material capable of binding the species to be assayed, said thin film incorporating a fluorescent compound whose fluorescent properties show a dependence upon it's molecular environment and said surface being optically active with respect to radiation over a predetermined band of wavelengths (b) contacting the coated surface with the sample and (c) measuring the change in fluorescent properties of said fluorescent compound before and after binding of said species. The preformed surface is preferably a diffraction grating.