Patents by Inventor Satish C. Bisarya

Satish C. Bisarya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of 3-keto-6-azido-4,6-bis-dehydro-steroids and intermediates useful therein
    Patent number: 3931167
    Abstract: Pharmacologically valuable 3-keto-6-azido-4,6-bis-dehydro-steroids are prepared by treating a 3-keto-6.beta.,7-diacyloxy-4-dehydro-steroid, preferably a 3-keto-6.beta.,7.beta.-diacyloxy-4-dehydrosteroid, wherein said acyloxy group is a good leaving group (e.g. hydrocarbonsulfonyloxy), with an azide salt in a nonreactive organic solvent. Novel intermediates for this process, i.e. novel 3-keto-6.beta.,7.beta.-dihydroxy-4-dehydro-steroids and 6.beta.,7.beta.-dihydrocarbonsulfonyloxy-esters thereof, are conveniently prepared by treating a 3-keto-4,6-bis-dehydro-steroid with osmium tetroxide followed by reductive cleavage of the 6.beta.,7.beta.-osmate ester thereby formed, isolating and thence esterifying the resulting 3-keto-6.beta.,7.beta.-dihydroxy-4-dehydro-steroid with a hydrocarbonsulfonyl halide in a tertiary amine.
    Type: Grant
    Filed: June 10, 1974
    Date of Patent: January 6, 1976
    Assignee: Schering Corporation
    Inventors: Michael J. Green, Satish C. Bisarya