Abstract: The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).

Abstract: Disclosed is process for the preparation of a key Rilpivirine intermediate namely, (E)-4-(2-cyanoethenyl)-2,6-dimethylphenylamine hydrochloride (II) by a process comprising reaction of the tetrafluoroborate salt of the diazonium ion of 2,6-dimethyl-4-amino-1-carboxybenzyl phenylamine (VI) with acrylonitrile in presence of palladium acetate, followed by treatment with an acid and its subsequent conversion to the hydrochloride salt (II), wherein the undesired Z isomer is less than 0.5% and provides Rilpivirine hydrochloride having Z isomer less than 0.1%.

Abstract: The present invention provides a simple and efficient method for synthesis of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride of desired purity.

Abstract: Controlled release oral dosage formulations containing calcium channel blocker and processes for preparation thereof, are provided for once a day treatment. The active agent is preferably a dihydropyridine calcium channel blocker, such as nisoldipine. In one embodiment, the formulation provides controlled release of micronized nisoldipine with one or more pH independent release controlling polymers. The controlled release matrix formulation is advantageous and can be prepared by a simple, economically viable process as compared to complex core-coat prior-art versions.

Abstract: Briefly, embodiments of methods or systems for client side browser notification are disclosed.

Abstract: Disclosed is process for the preparation of a key Rilpivirine intermediate namely, (E)-4-(2-cyanoethenyl)-2,6-dimethylphenylamine hydrochloride (II) by a process comprising reaction of the tetrafluoroborate salt of the diazonium ion of 2,6-dimethyl-4-amino-1-carboxybenzyl phenylamine (VI) with acrylonitrile in presence of palladium acetate, followed by treatment with an acid and its subsequent conversion to the hydrochloride salt (II), wherein the undesired Z isomer is less than 0.5% and provides Rilpivirine hydrochloride having Z isomer less than 0.1%.

Abstract: The present invention provides a convenient and industrially viable process for preparation of Zolmitriptan (I) having desired purity. The invention specifically relates to a method for isolating (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) of desired purity by separating the undesired inorganic side products such as stannous hydroxide by manipulation of pH at different stages and finally treating with N,N-dimethylamino butyraldehyde diethyl acetal in an acidic medium to provide Zolmitriptan (I) conforming to regulatory specifications.

Abstract: A computer-implemented method for sponsored applications includes: loading a smart tag with metadata about an application to be downloaded on a user device, said metadata including information about the application that assists an ad server in selecting a targeted advertisement relevant to said application; programming the smart tag to communicate with the ad server requesting service of relevant, targeted ads to the user device based on the metadata once the application is transmitted to the user device and upon each invocation of the application thereafter; and placing the smart tag on the application to be made available for download.

Abstract: The present invention provides a simple method for preparation of benzphetamine and its acid addition salt comprising reaction of methamphetamine hydrochloride of formula (III) with benzyl chloride and treating the isolated benzphetamine of formula (II) with an acid dissolved in an organic solvent to provide benzphetamine acid addition salt, more specifically, benzphetamine hydrochloride of formula (I).

Abstract: In one embodiment, a method for estimating pose includes generating hypotheses for a pose component under consideration, identifying a mode of a probability mass function associated with the hypotheses, extracting low-noise hypotheses, and averaging the low-noise hypotheses to obtain a pose component estimate.

Abstract: A method of estimating position and orientation of a vehicle using image data is provided. The method includes capturing an image of a region external to the vehicle using a camera mounted to the vehicle, and identifying in the image a set of feature points of the region. The method further includes subsequently capturing another image of the region from a different orientation of the camera, and identifying in the image the same set of feature points. A pose estimation of the vehicle is generated based upon the identified set of feature points and corresponding to the region. Each of the steps are repeated at with respect to a different region at least once so as to generate at least one succeeding pose estimation of the vehicle. The pose estimations are then propagated over a time interval by chaining the pose estimation and each succeeding pose estimation one with another according to a sequence in which each was generated.

Abstract: The present invention provides a simple and efficient method for synthesis of 4-[bis (2-chloroethyl)-amino]-L-phenylalanine hydrochloride. The process involves the treatment of 4-[bis(2-chloroethyl)-amino]-L-phenylalanine free base with hydrochloric acid in water followed by isolation of 4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride of desired purity.

Abstract: Computer implemented methods, programs and systems for displaying statistical data in a graphical user interface are provided. According to the method, baseline data is imported from a first report which corresponds to a trouble-free period. Similarly, critical data is imported from a second report corresponding to a trouble period. The imported data is compared and analyzed to create a results table, each cell in the results table corresponding to a timestamp and a statistical item. The cells in the results table contain a visual identifier according to the criticality of the comparison of the statistical items from the baseline data and the critical data. The results table is presented on a display to the user.

Abstract: A method for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor such as etravirine is provided Typically, etravirine is synthesized by the steps of a Condensing 2,4,6-trichlorpyrimidine with 3,5-dimethyl-4-hydroxybenzonitrile to obtain compound (V), b Condensing compound (V) with 4-aminobenzonitrile to obtain compound (VI), c Ammonolysis of compound (VI) to get compound (IV), d Halogenation of compound (IV) to get etravirine.

Abstract: Techniques are described herein for monetizing page views on an exchange using futures contracts. For example, an estimated price (a.k.a. base price) and a future date (a.k.a. base date or occurrence date) may be declared with respect to a page view. The estimated price is the price at which the page view is to be offered for sale. The future date is the date on which the page view is scheduled to occur. A futures contract regarding the page view is offered for sale on an exchange, such as an ad exchange. The futures contract specifies an obligation to purchase the page view with respect to the future date for the estimated price. The futures contract may be offered for sale on a date that precedes the date on which the page view is to be offered for sale.

Abstract: A method and system for facilitating the operation of an Internet website is provided. The method employed by the system may include receiving, at an exchange, information about a publisher's website for which the publisher wishes to sell shares and communicating the information to an investor. The investor may then generate a purchase order for purchasing a number of shares in the publisher's website. A money amount may then be transferred from an account associated with the investor to an account associated with the publisher. At a later time, dividends may be paid to the investor or an investor may sell his shares in the website to a different investor.

Abstract: Computer implemented methods, programs and systems for displaying statistical data in a graphical user interface are provided. According to the method, baseline data is imported from a first report which corresponds to a trouble-free period. Similarly, critical data is imported from a second report corresponding to a trouble period. The imported data is compared and analyzed to create a results table, each cell in the results table corresponding to a timestamp and a statistical item. The cells in the results table contain a visual identifier according to the criticality of the comparison of the statistical items from the baseline data and the critical data. The results table is presented on a display to the user.

Abstract: A method and apparatus are provided for collecting information about targeted behavior on the Internet. In one example, the method includes sending an offer to participate in a tracking program to a user computer, receiving an acceptance of the offer to participate from the user computer, sending a software code device to the user computer, receiving targeted behavior information from the software code device located on the user computer, and sending payment for the targeted behavior information to the user computer.

Abstract: A device, system and method to enable a user to create a customized or tailored image of a web page that is specific to, and can be displayed on, a mobile, web-enabled device. The tailored image of the web page may include enlargeable images of subsections of the web page that are accessed by the user clicking on or scrolling over the subsection of the tailored image. The tailored image may also include hotspots corresponding to selectable elements of the web page.

Abstract: Ads servers, clients, and networks serve and/or publish ads through online networks, then track offline-interface events that operate on the ads, and charge advertisers based on the offline-interface events. An enabling network includes an ads publishing module to request an ad from an ads serving module and publish the ad, a tracking module to track offline-interface events that operate on the published ad, and a billing module to charge an advertiser based on the offline-interface events.