Patents by Inventor Satish Pulapura
Satish Pulapura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10767006Abstract: A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.Type: GrantFiled: May 7, 2018Date of Patent: September 8, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Dan Thanh Le, Xiangji Chen, Suping Lyu, Fatima Buevich
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Patent number: 10765782Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate and a hemostatic agent. The substrate includes a first piece and a second piece that is joined with the first piece. The first piece includes the hemostatic agent and the second piece includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed.Type: GrantFiled: May 1, 2017Date of Patent: September 8, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Jorie S. Soskin, Franklin R. Mansfield, Kai R. Worrell, Charlie Wood, Jorge Alberto Trevino Blanco
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Patent number: 10765500Abstract: The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use.Type: GrantFiled: May 9, 2018Date of Patent: September 8, 2020Assignee: MEDTRONIC, INC.Inventors: Fatima Buevich, Frank Do, William McJames, Satish Pulapura, William Edelman, Arikha Moses, Mason Diamond, Shari Timothy
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Patent number: 10736998Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: May 9, 2019Date of Patent: August 11, 2020Assignee: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura
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Patent number: 10737004Abstract: A medical prosthesis includes a tube having a length between a first end and a second end. The tube includes a polymer and at least one drug. The tube is configured to be manipulated to selectively increase and decrease the length of the tube. Kits, systems and methods are disclosed.Type: GrantFiled: December 26, 2017Date of Patent: August 11, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Jorie Soskin, Jonathan Sturtevant
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Patent number: 10442757Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: GrantFiled: May 7, 2018Date of Patent: October 15, 2019Assignee: Medtronic, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
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Patent number: 10420864Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a first component having a first substrate and a second component having a second substrate. The second component is positioned within the first component. One of the first and second substrates includes a hemostatic agent and the other of the first and second substrates includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed.Type: GrantFiled: May 1, 2017Date of Patent: September 24, 2019Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Jorie S. Soskin, Franklin R. Mansfield, Kai R. Worrell, Charlie Wood
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Publication number: 20190262510Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: ApplicationFiled: May 9, 2019Publication date: August 29, 2019Applicant: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura
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Patent number: 10314951Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: April 26, 2018Date of Patent: June 11, 2019Assignee: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
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Publication number: 20190125938Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: ApplicationFiled: April 26, 2018Publication date: May 2, 2019Applicant: TYRX, Inc.Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
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Publication number: 20190030218Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate and a hemostatic agent. The substrate includes a first piece and a second piece that is joined with the first piece. The first piece includes the hemostatic agent and the second piece includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed.Type: ApplicationFiled: May 1, 2017Publication date: January 31, 2019Applicant: TYRX, Inc.Inventors: SATISH PULAPURA, FATIMA BUEVICH, JORIE S. SOSKIN, FRANKLIN R. MANSFIELD, KAI R. WORRELL, CHARLIE WOOD, JORGE ALBERTO TREVINO BLANCO
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Publication number: 20180354892Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCl HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: TYRX, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
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Publication number: 20180355103Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: TYRX, Inc.Inventors: SATISH PULAPURA, FATIMA BUEVICH, XIANGJI CHEN, SUPING LYU
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Publication number: 20180355104Abstract: A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: Tyrx, Inc.Inventors: SATISH PULAPURA, DAN THANH LE, XIANGJI CHEN, SUPING LYU, FATIMA BUEVICH
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Patent number: 10086115Abstract: An anchorage device comprising a mesh substrate coupled to an implantable medical device is disclosed, where the mesh substrate has a coating comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the mesh over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.Type: GrantFiled: October 4, 2013Date of Patent: October 2, 2018Assignee: TYRX, Inc.Inventors: William McJames, Frank Do, Satish Pulapura, Qing Ge
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Publication number: 20180256306Abstract: The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use.Type: ApplicationFiled: May 9, 2018Publication date: September 13, 2018Applicant: Tyrx, Inc.Inventors: Fatima Buevich, Frank Do, William McJames, Satish Pulapura, William Edelman, Arikha Moses, Mason Diamond, Shari Timothy
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Patent number: 10034969Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: March 6, 2018Date of Patent: July 31, 2018Assignee: TYRX, Inc.Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
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Publication number: 20180193540Abstract: A medical prosthesis includes a tube having a length between a first end and a second end. The tube includes a polymer and at least one drug. The tube is configured to be manipulated to selectively increase and decrease the length of the tube. Kits, systems and methods are disclosed.Type: ApplicationFiled: December 26, 2017Publication date: July 12, 2018Applicant: TYRX, Inc.Inventors: Satish Pulapura, Fatima Buevich, Jorie Soskin, Jonathan Sturtevant
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Patent number: 9987400Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: February 5, 2018Date of Patent: June 5, 2018Assignee: TYRX, Inc.Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
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Patent number: 9987116Abstract: The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use.Type: GrantFiled: July 26, 2016Date of Patent: June 5, 2018Assignee: TYRX, Inc.Inventors: Fatima Buevich, Frank Do, William McJames, Satish Pulapura, William Edelman, Arikha Moses, Mason Diamond, Shari Timothy