Abstract: Techniques are described for snapshot key inter-dependency resolution during cross-region replications. Dependency between a first type of replication-related information (e.g., crypto keys associated with a parent directory iNode or a file iNode) and a second type of replication-related information (e.g., files, file data/FMAPs, or symbolic links) during a cross-region replication may be resolved to enable non-blocking delta application in a target file system. In some embodiments, temporary dummy entries for the first type of information may be created in the B-tree of the target file system for the out-of-order download (e.g., the second type being downloaded before the first type) of these two types of information. In some embodiments, a consolidation process may be performed between the dummy entries and the later-arriving first type of information.

Abstract: Techniques are described for enabling concurrent and non-blocking replication object deletion during cross-region replications. In some embodiments, in a target file system, a target replication pipeline as part of a cross-region replication, and a deletion pipeline operate in parallel. The deletion pipeline deletes processed objects reaching the last pipeline stage of the target replication pipeline after each checkpoint in the target replication pipeline. In some embodiments, after a non-recoverable failure during the cross-region replication, the cross-region replication can be restarted from the beginning (i.e., fresh restart) without waiting for its unused objects in the Object Store to be deleted by utilizing a generation number associated with each object to delete the unused objects in a background process while allowing deleting processed objects as normal for the freshly restarted cross-region replication.

Abstract: Techniques are described for enabling replication-aware resource management and task management in a cloud infrastructure for cross-region replication. In some embodiments, each replication job is associated with a set of replication-related information. In certain embodiments, the replication-aware resource management allocates resources, using a combination of various resource allocation schemes, to a fleet of replicators to allow the fleet to select replication jobs in a job queue, and perform resource scaling based on monitored performance metrics reported by the fleet. In some embodiments, the replication-aware task management enables replication job selection based on the set of replication-related information to optimize the performance of all cross-region replications in the region.

Abstract: The present disclosure relates to techniques for the treatment of patient tissue. The techniques may include resection or removal of such tissue. Error reduction in the identification and presentation of specific tissue types may be realized through these techniques. An image may be received that provides a visual representation of the tissue. Pixels of the image may be segmented to form a boundary. Portions of the image may be classified for resection and resection of the tissue may be performed.

Abstract: The present invention relates to the development of new derivatives of a bacterial plasminogen activator, Staphylokinase (SAK), having one or more amino acid residues with single or multiple cysteines at the amino and/or carboxy terminal ends and their conjugation with PEG (Polyethylene Glycol), resulting in new Staphylokinase derivatives that display altered oligomeric states, enhanced thermal and protease stability and extended plasma half-life. Also included is the cloning and expression in a suitable bacterial host; purification of Staphylokinase derivatives to homogeneity and their chemical modification by integrating a PEG molecule to create new biologically active Staphylokinases having higher protein stability and improved in vivo plasma half life, that may enhance the clinical potential of Staphylokinase in thrombolytic therapy for the treatment of cardiovascular diseases.

Abstract: The present invention provides for novel compositions of anti-CTLA-4 antibodies comprising a chelating agent. Also provided are method of treating diseases and conditions with novel compositions of CTLA-4 antibodies, including various neoplasia conditions.

Abstract: The present invention relates to the development of new derivatives of a bacterial plasminogen activator, Staphylokinase (SAK), having one or more amino acid residues with single or multiple cysteines at the amino and/or carboxy terminal ends and their conjugation with PEG (Polyethylene Glycol), resulting in new Staphylokinase derivatives that display altered oligomeric states, enhanced thermal and protease stability and extended plasma half-life. Also included is the cloning and expression in a suitable bacterial host; purification of Staphylokinase derivatives to homogeneity and their chemical modification by integrating a PEG molecule to create new biologically active Staphylokinases having higher protein stability and improved in vivo plasma half life, that may enhance the clinical potential of Staphylokinase in thrombolytic therapy for the treatment of cardiovascular diseases.

Abstract: A method for generating a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system involves processing a complex vector to generate a processed complex vector and performing an inverse fast Fourier transform on the processed complex vector to generate a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system.

Abstract: A method for generating a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system involves processing a complex vector to generate a processed complex vector and performing an inverse fast Fourier transform on the processed complex vector to generate a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system.

Abstract: A method is provided for managing a transmit buffer using per priority pause flow control. An Ethernet transceiver generates packet descriptors identifying packets to be transmitted that are stored in memory. A priority is assigned to each descriptor and associated packet. Each descriptor is loaded into a queue having a queue priority associated with the descriptor priority. In response to accessing a first descriptor, output from a selected first priority queue, a first packet associated with the first descriptor is fetched into a transmit buffer from the memory. If subsequent to fetching the first packet, a per priority flow control message is received pausing first priority packets, the first packet is flushed from the transmit buffer. Then, a second descriptor is accessed from a selected second priority queue, and a second packet associated with the second descriptor is fetched and transmitted from the transmit buffer.

Abstract: A presence information system reports proximity presence status to presence subscribers. The proximity presence status conveys how far an individual is from a phone, computer, or any other endpoint through which the individual communicates, how far the individual is from a presence information server which tracks presence changes, or how far the individual is from any other location, such as an office or a conference room. The proximity presence status supplements static presence states such as ‘Online’ and ‘Offline’. As a result, the proximity presence status helps to provide a more accurate picture of the true presence status of an individual. The presence information system may also track and report proximity presence status of mobile users. The mobile user proximity presence status may be derived from cellular position data obtained from a cellular service provider.

Abstract: The present invention relates to an endoscopic biopsy forceps (10) with an open central channel. The forceps include a sheath (20) having a proximal end and a distal end, a housing (50) connected with the distal end of the outer sheath, an open channel actuator control means (30) having a proximal end and a distal end and passing through the sheath, an operating means attached to the proximal end of the open channel actuator means, an open channel actuator (60.) attached to a distal end of the open channel actuator control means and having a first projection and second projection, a first jaw (40) having an actuator engagement projection and having a first position and a second position, and a second jaw having an actuator engagement projection and a first position and a second position.

Abstract: The present invention relates to the development of new derivatives of a bacterial plasminogen activator, Staphylokinase (SAK), having one or more amino acid residues with single or multiple cysteines at the amino and/or carboxy terminal ends and their conjugation with PEG (Polyethylene Glycol), resulting in new Staphylokinase derivatives that display altered oligomeric states, enhanced thermal and protease stability and extended plasma half-life. Also included is the cloning and expression in a suitable bacterial host; purification of Staphylokinase derivatives to homogeneity and their chemical modification by integrating a PEG molecule to create new biologically active Staphylokinases having higher protein stability and improved in vivo plasma half life, that may enhance the clinical potential of Staphylokinase in thrombolytic therapy for the treatment of cardiovascular diseases.

Abstract: The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with carbon particles, for example carbon nanotubes. The microfluidic devices and methods of the present invention are useful for cell lysis of cells within a biological sample, such as a untreated biological sample comprising microorganisms, such as but not limited to gram positive and gram negative bacteria.

Abstract: A method for generating a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system involves processing a complex vector to generate a processed complex vector and performing an inverse fast Fourier transform on the processed complex vector to generate a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system.

Abstract: Biopsy instruments are integrated with a multi-fiber optical probe adapted to perform diagnostic measurements. In addition to being able to analyze, treat or remove tissue, such integrated devices characterize tissue by measuring the amount of scattering and absorption of light transmitted into the tissue. Each fiberoptic probe has an illuminating fiber that provides a broadband light source for transmission into tissue, and a collecting fiber that collects the light scattered by the tissue and transmits the collected light to a spectrometer. One embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a multi-fiber optical probe which is conveyed through a hollow central channel. Another embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a plurality of multi-fiber optical probes. Yet another embodiment is an endoscopic polypectomy-type snare catheter with a multi-fiber optical probe located at the tip.

Abstract: A system and method for broadcasting a message to multiple contacts in a list of contacts provided by an electronic mail application and furnishing presence information for contacts in the list of contacts provided by the electronic mail application includes an interface for adding functionality to an electronic mail application which supports instance messaging (IM). The interface interfaces with a distributed presence enabled communication platform for providing presence information regarding contact availability. The electronic mail application utilizes the interface for displaying the contact presence information and broadcasting a message to multiple contacts in the list of contacts.

Abstract: The present invention provides for novel compositions of anti-CTLA-4 antibodies comprising a chelating agent. Also provided are method of treating diseases and conditions with novel compositions of CTLA-4 antibodies, including various neoplasia conditions.

Abstract: A presence information system reports proximity presence status to presence subscribers. The proximity presence status conveys how far an individual is from a phone, computer, or any other endpoint through which the individual communicates, how far the individual is from a presence information server which tracks presence changes, or how far the individual is from any other location, such as an office or a conference room. The proximity presence status supplements static presence states such as ‘Online’ and ‘Offline’. As a result, the proximity presence status helps to provide a more accurate picture of the true presence status of an individual. The presence information system may also track and report proximity presence status of mobile users. The mobile user proximity presence status may be derived from cellular position data obtained from a cellular service provider.

Abstract: A system and method for broadcasting a message to multiple contacts in a list of contacts provided by an electronic mail application and furnishing presence information for contacts in the list of contacts provided by the electronic mail application includes an interface for adding functionality to an electronic mail application which supports instance messaging (IM). The interface interfaces with a distributed presence enabled communication platform for providing presence information regarding contact availability. The electronic mail application utilizes the interface for displaying the contact presence information and broadcasting a message to multiple contacts in the list of contacts.