Abstract: The present invention relates to a hollow fiber membrane module for outside-in cross-flow filtration including: a container having at least a raw water inlet, a raw water outlet, and a filtrate outlet; and a plurality of hollow fiber membranes housed in the container, in which in the plurality of hollow fiber membranes, an end portion on a raw water inlet side is sealed and an end portion on a filtrate outlet side is opened, and the plurality of hollow fiber membranes have a potting portion fixed by an adhesive at least in the end portion on the filtrate outlet side, and a pure water permeability K (m3/m2/hr/50 kPa) of the hollow fiber membranes and an inner diameter Di (?m) of the hollow fiber membranes satisfy the following requirements: 2.0?K?20.0; and 350?D1?600.

Abstract: The present invention relates to a separation membrane including an organic polymer resin, in which a volume V1 of fine pores having a pore diameter of 100 nm or more is 0.3 cm3/g or more and 0.5 cm3/g or less, a volume V2 of fine pores having a pore diameter of less than 100 nm is 0.02 cm3/g or more and less than 0.1 cm3/g, and a ratio V1/V2 of the fine pore volume V1 to the fine pore volume V2 is 3 or more and 60 or less.

Abstract: The present invention relates to a separation membrane including an organic polymer resin, in which a volume V1 of fine pores having a pore diameter of 100 nm or more is 0.3 cm3/g or more and 0.5 cm3/g or less, a volume V2 of fine pores having a pore diameter of less than 100 nm is 0.02 cm3/g or more and less than 0.1 cm3/g, and a ratio V1/V2 of the fine pore volume V1 to the fine pore volume V2 is 3 or more and 60 or less.

Abstract: Provided is a chemical product production method wherewith filterability and productivity with respect to a target substance can be both achieved. The present invention is provided with a mechanism for removing solid contents in a pipe connecting a fermentation tank and a filter separation module, and adds the solid contents removed by the removal mechanism to a culture liquid.

Abstract: Provided is a filter having either or both of a winding and a laminate that include a fiber-like absorbing material, wherein the fiber-like absorbing material has a base material and metal particles supported on the base material, and the diameter D of the fiber-like absorbing material, the void fraction of the winding or laminate, and the variation in the area void fraction in the radial direction of the winding or the variation in the area void fraction in the direction of lamination are in a specific range.

Abstract: The present invention provides a filter which, even when raw water is subjected to high-speed treatment, enables achieving a high solute rejection ratio and a long solute filtration life and which exhibits a low water flow resistance. The present invention pertains to a filter obtained by laminating woven fabrics or knitted fabrics, the filter being characterized in that: said woven fabrics or knitted fabrics comprise a fiber capable of adsorbing components dissolved in liquid: said fiber has a diameter of 100-600 ?m; the woven fabrics or knitted fabrics have a porosity of 15-70%; and variation in area porosity in the thickness direction of the laminate is 15% or less.

Abstract: The present invention provides a filter which, even when raw water is subjected to high-speed treatment, enables achieving a high solute rejection ratio and a long solute filtration life and which exhibits a low water flow resistance. The present invention pertains to a filter obtained by laminating woven fabrics or knitted fabrics, the filter being characterized in that: said woven fabrics or knitted fabrics comprise a fiber capable of adsorbing components dissolved in liquid: said fiber has a diameter of 100-600 ?m; the woven fabrics or knitted fabrics have a porosity of 15-70%; and variation in area porosity in the thickness direction of the laminate is 15% or less.

Abstract: The present invention relates to an ion exchange fiber including: a core fiber; and an ion exchange layer that is disposed at a vicinity of the core fiber and includes a crosslinked polymer compound having an ion exchange group, in which, in a cross section perpendicular to a longitudinal direction of the ion exchange fiber, an area of the ion exchange layer occupies 50% or more and 90% or less of a total cross sectional area, and the ion exchange fiber has a swelling ratio of 50% or less.

Abstract: The present invention relates to a method for filtering a microbial culture solution using a membrane module, said method comprising four stages including (a) cross-flow filtration of the microbial culture solution, (b) rinsing with water, (c) washing with a chemical solution and (d) rinsing with water, wherein: the filtrate passing through the membrane module in the cross-flow filtration has a total sugar concentration of 1,000-100,000 mg/1 inclusive and a protein concentration of 50-1,000 mg/l inclusive; the aforesaid stage (c) comprises step (c-1) for washing with a chemical solution containing a hypochlorite and a nonionic surfactant; and the aforesaid stages (a) to (d) are repeated in this order.

Abstract: A method of producing a chemical includes culturing cells in a culture solution in a fermentor to ferment a feedstock to produce a chemical; supplying the culture solution containing the chemical produced in the culturing to a plurality of separation membrane units arranged in parallel; filtering the culture solution supplied in the supplying to separate a permeate containing the chemical; refluxing a retentate that is not filtered in the filtering to the fermentor; and supplying a gas containing oxygen to the plurality of separation membrane units while a supply amount is changed to at least two different values to perform scrubbing, wherein the supply amount and supply time of the gas containing oxygen supplied in the culturing and the supplying the gas are set so that a kLa value is within a predetermined range from an optimal kLa value for the cells cultured in the culturing.

Abstract: The present invention relates to a method for operating a separation membrane module including a separation membrane having a first face and a second face, a liquid-to-be-filtrated flow channel along which liquid to be filtrated which is to be fed to the first face flows, and a permeated-liquid flow channel along which permeated liquid obtained from the second face flows, the method including: a filtration step of obtaining permeated liquid containing components that become insoluble when coming into contact with acids by feeding liquid to be filtrated to the liquid-to-be-filtrated flow channel; a first water substitution step of substituting liquid in the permeated-liquid flow channel with water, after the filtration step; a first chemical cleaning step of performing backwashing by causing an acidic chemical solution to flow from the second face toward the first face of the separation membrane, after the first water substitution step; and a second water substitution step of substituting liquid in the permeat

Abstract: A packing container includes a packing container body having an opening, and a cushioning member provided in the packing container body. The cushioning member includes a cushioning-member body portion, and a pushing portion that pushes a packing object toward a side of the opening.

Abstract: A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to produce a chemical; (b) conducting filtration of the culture medium with a separation membrane module; (c) separating a permeate containing the chemical from the culture medium while retaining a non-permeated liquid in the fermentor, and (d) supplying a gas from at least one of a lower portion of the separation membrane module and a pipe communicating between the fermentor and the separation membrane module to adjust a gas linear velocity in the separation membrane module to 0.15 cm/s to 70 cm/s while supplying the separation membrane module with a liquid.

Abstract: An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.

Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

Abstract: A method of producing a chemical includes culturing cells in a culture solution in a fermentor to ferment a feedstock to produce a chemical; supplying the culture solution containing the chemical produced in the culturing to a plurality of separation membrane units arranged in parallel; filtering the culture solution supplied in the supplying to separate a permeate containing the chemical; refluxing a retentate that is not filtered in the filtering to the fermentor; and supplying a gas containing oxygen to the plurality of separation membrane units while a supply amount is changed to at least two different values to perform scrubbing, wherein the supply amount and supply time of the gas containing oxygen supplied in the culturing and the supplying the gas are set so that a kLa value is within a predetermined range from an optimal kLa value for the cells cultured in the culturing.

Abstract: A method produces a concentrated aqueous sugar solution using a cellulose-containing biomass as a raw material, including: (1) hydrolyzing a cellulose-containing biomass to produce an aqueous sugar solution; (2) filtering the aqueous sugar solution obtained in (1) through a microfiltration membrane and/or an ultrafiltration membrane, and recovering an aqueous sugar solution from the permeate side; and (3) filtering the aqueous sugar solution obtained in (2) through a nanofiltration membrane and/or a reverse osmosis membrane, recovering a permeate from the permeate side and recovering a concentrated aqueous sugar solution from the feed side; wherein at least a part of the permeate from the nanofiltration membrane and/or the reverse osmosis membrane is used as a washing liquid in (1) and/or (2).

Abstract: A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to produce a chemical; (b) conducting filtration of the culture medium with a separation membrane module; (c) separating a permeate containing the chemical from the culture medium while retaining a non-permeated liquid in the fermentor, and (d) supplying a gas from at least one of a lower portion of the separation membrane module and a pipe communicating between the fermentor and the separation membrane module to adjust a gas linear velocity in the separation membrane module to 0.15 cm/s to 70 cm/s while supplying the separation membrane module with a liquid.

Abstract: A method of sterilizing a separation membrane module reduces damage of a ceramic separation membrane, a sterilization process device achieves the method of sterilizing, and an apparatus produces chemicals. The method of sterilizing the separation membrane module includes a ceramic-containing separation membrane including a temperature raise step of raising the temperature of the separation membrane module to a predetermined sterilization temperature by feeding sterilization water having a controlled temperature and pressure so that a rate of temperature change of the separation membrane module is 6.0° C. or less per minute, and a sterilization step of sterilizing the separation membrane module at a predetermined temperature for a predetermined time.