Abstract: A computer-implemented system is capable of evaluating the net present value (NPV) of a product development program having a number of strategic alliance components, such as guaranteed research payments, royalty payments, milestone payments, and the like. The evaluation system is iterative in nature—it calculates an overall NPV for each simulation iteration and generates statistical distributions that reflect the mean and median NPVs. The evaluation system allows the end user to designate specific deal structure terms prior to the simulation. Alternatively, the evaluation system can generate default or suggested development and/or sales assumptions based on historical or empirical clinical data related to actual product development programs.