Patents by Inventor Satoru Nakai
Satoru Nakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6107465Abstract: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.Type: GrantFiled: March 10, 1987Date of Patent: August 22, 2000Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 6030839Abstract: Preparations are made of a characteristic curve of conductivity showing the relationship between sodium concentration in alcohol and conductivity of alcohol as observed at a predetermined temperature and a temperature correction curve showing the change in conductivity per unit degree centigrade of alcohol temperature versus; sodium concentration in alcohol; the corrected conductivity of a sample alcohol is determined by measuring the conductivity and temperature of the sample alcohol simultaneously and subjecting the measured conductivity to temperature correction according to the above temperature correction curve; and then the sodium concentration in the sample alcohol is determined on the basis of the corrected conductivity thus obtained. Thus, the change in sodium concentration in alcohol can be measured and monitored continuously and accurately.Type: GrantFiled: March 9, 1998Date of Patent: February 29, 2000Assignee: Japan Nuclear Cycle Development InstituteInventors: Shinpei Yamamoto, Satoru Nakai, Toshio Yatabe
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Patent number: 5925640Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: July 20, 1999Assignee: Otsuka Pharmaceutical Co. Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5916890Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: June 29, 1999Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5872120Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: February 16, 1999Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5849282Abstract: This invention provides an anti-tumor agent and a method for treating a tumor wherein gamma-interferon and interleukin-1 are used as active ingredients.Type: GrantFiled: December 23, 1993Date of Patent: December 15, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kazuyoshi Kawai, Yasue Konishi, Satoru Nakai, Yoshikatsu Hirai
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Patent number: 5847098Abstract: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.Type: GrantFiled: June 7, 1995Date of Patent: December 8, 1998Assignee: Otsuka Pharmaceutcal Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5837230Abstract: This invention provides medical uses of a M-CSF, particularly a method and composition for treating inflammatory disease and allergy using natural M-CSF or recombinant M-CSF or the derivatives thereof.Type: GrantFiled: June 5, 1995Date of Patent: November 17, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Masayuki Takahashi, Hiroyuki Ichikawa, Yoshikatsu Hirai
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Patent number: 5798358Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: August 25, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5756675Abstract: The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.Type: GrantFiled: June 6, 1994Date of Patent: May 26, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikatsu Hirai, Satoru Nakai, Koutoku Aihara, Kazuyoshi Kawai, Mayumi Kaneta, Takashi Kamogashira, Yoshihiro Masui
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Patent number: 5750529Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: May 12, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5723117Abstract: A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and GPT activities in blood which are markers of liver diseases, and also suppresses symptoms such as choloplania.Type: GrantFiled: October 22, 1993Date of Patent: March 3, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Seiji Akamatsu, Yoshihiro Masui, Tsutomu Nishida, Takashi Kamogashira, Yoshikatu Hirai
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Patent number: 5702698Abstract: Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.Type: GrantFiled: June 5, 1995Date of Patent: December 30, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5691341Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.Type: GrantFiled: August 29, 1995Date of Patent: November 25, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi
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Patent number: 5672603Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: September 30, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5658912Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: August 19, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5650297Abstract: This invention relates to a biologically active recombinant human M-CSF obtained by expressing a human M-CSF gene coding for the amino acid sequence of the formula (1) in its entirety or devoid of a portion thereof; a process for preparing the recombinant human M-CSF; an expression plasmid containing the human M-CSF gene defined above; and a transformant haboring the above expression plasmid.Type: GrantFiled: July 27, 1994Date of Patent: July 22, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masayuki Takahashi, Tohru Hirato, Satoru Nakai, Yeong-Man Hong, Naomi Kouno, Yoshikatsu Hirai
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Patent number: 5543140Abstract: Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1.alpha. (IL-1.alpha.) derivatives, are disclosed.Type: GrantFiled: June 1, 1994Date of Patent: August 6, 1996Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5543412Abstract: An object of the invention is to provide hepatitis therapy. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: August 6, 1996Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Patent number: 5464833Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.Type: GrantFiled: April 19, 1994Date of Patent: November 7, 1995Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi