Abstract: An abnormality diagnosis device for a ball screw includes a vibration sensor that detects vibration during an operation of the ball screw, a filter processing unit that executes, on a vibration signal acquired by the vibration sensor, filtering processing for extracting a frequency band including at least a characteristic frequency corresponding to a specific frequency of the ball screw, an envelope processing unit that executes envelope processing for a vibration signal after the filtering processing, a frequency analysis processing unit that executes fast Fourier transform processing on a time domain signal after the envelope processing, a peak hold averaging processing unit that executes peak hold averaging processing for frequency domain data for each sampling period in the fast Fourier transform processing, and an abnormality determination unit.

Abstract: A bagmaking and packaging machine forms a packaging material in a tubular shape and packages packaging articles. The bagmaking and packaging machine includes a former, a wraparound member, and a support member. The former folds and guides the packaging material. Around the wraparound member is wrapped the packaging material folded by the former. The support member supports the former and the wraparound member. The former includes a collar member that guides the packaging material and a first tube member for forming in a tubular shape the packaging material guided by the collar member. The first tube member has one end to which the collar member is connected, and includes a first mating portion that is mated with the support member.

Abstract: Provided is a pharmaceutical composition for treating or preventing peripheral neuropathy induced by a chemotherapy drug, the pharmaceutical composition containing an alkalinizing agent. Administration of this pharmaceutical composition enables the treatment or prevention of peripheral neuropathy induced by a chemotherapy drug, particularly a cancer chemotherapy drug. Also provided is an anticancer pharmaceutical composition which contains an alkalinizing agent and a cancer chemotherapy drug, and exhibits suppressed expression of peripheral neuropathy. Administration of this pharmaceutical composition enables cancer treatment with suppressed expression of peripheral neuropathy.

Abstract: An information processing device, an information processing method, and a program capable of creating a screen more efficiently are provided. An information processing device according to an embodiment includes a display control unit, a reception unit, and a storage control unit. The display control unit displays a display screen for arranging a plurality of components each of which has a predetermined function. The reception unit receives settings of the components designated using the display screen. The storage control unit stores, in a storage device, setting information indicating the settings received. The display control unit displays the display screen on which the components are set in accordance with the setting information.

Abstract: A robot system includes a multi-joint robot arm including a plurality of joints; a robot controller configured or programmed to control movement of the multi-joint robot arm; an interactor configured to interact with a workpiece; a signal output configured to output a moving amount signal based on a moving amount of the interactor arranged on a distal end part of the multi-joint robot arm at a fixed time period; and an interaction controller configured or programmed to control interaction of the interactor with the workpiece based on the moving signal output by the signal output.

Abstract: A film roll replacement device supplies a film roll to a bag making and packaging machine, which has a film-roll-supporting part to support the film roll and which manufactures bags containing articles using the film. The film roll replacement device includes a holding section, the driving unit, and a controller. The holding section is located adjacent to the bag making and packaging machine, and the holding section holds the film roll supplied to the bag making and packaging machine. The driving unit moves the holding section. The controller controls an action of the driving unit to move the holding section to move in a first direction toward the supporting part of the bag making and packaging machine and to transfer the film roll held by the holding section to the supporting part.

Abstract: A submersible vessel includes: a hull; a propulsor that propels the hull; a front sensor that sequentially detects locations of an inspection target in front of the hull; a controller that controls the propulsor such that the hull passes through above the detected locations; a movable arm attached to an arm reference point of the hull; an inspection tool at the movable arm that inspects the inspection target; and a position detector that acquires positional information including a position, attitude, or speed of the hull. Based on the information from the position detector, the controller estimates a pass-through position of the arm reference point after a predetermined time. The controller controls the movable arm such that before the time elapses, a positional relation between the arm reference point and inspection tool becomes a positional relation between the estimated pass-through position and a target point on or above each location.

Abstract: An environment control device includes a control unit usable to control an environment adjustment portion that controls a thermal environment of a space. The control unit estimates a sensation indicating comfort or discomfort of a target person based on sensation information about the target person in the space. The control unit determines, based on an appearance frequency of each sensation corresponding to a thermal index value as a value of thermal index, a range of the thermal index value indicating comfort or discomfort as a sensation region. The control unit sets a target value of the thermal index in the space based on the sensation region. The control unit determines a duration of comfort or discomfort sensation. The control unit determines the sensation region by excluding the thermal index value where the duration of the comfort or discomfort sensation is shorter than a predetermined time.

Abstract: A film roll replacement device supplies a film roll to a bag making and packaging machine. The film roll replacement device includes a holding section, a driving unit, and a controller. The holding section is at least temporarily located adjacent to a supporting shaft to support the film roll in the bag making and packaging machine, and the holding section holds a first film roll supplied to the bag making and packaging machine. The driving unit moves the holding section in an up-down direction. The controller controls an action of the driving unit to move the holding section to a position where a height position of a center of the first film roll held by the holding section is aligned with the height of a center of the supporting shaft of the bag making and packaging machine.

Abstract: A bagmaking and packaging apparatus includes a film conveyance mechanism, a former mechanism, a transverse sealing mechanism, and a first partition member. The film conveyance mechanism conveys a film. The former mechanism includes a product feed chute and a former. The product feed chute has a product fed to it. The former forms in a tubular shape the film conveyed by the film conveyance mechanism. The transverse sealing mechanism is disposed under the former mechanism. The transverse sealing mechanism transversely seals the tubular film to make bags containing the product fed from the product feed chute. The first partition member partitions a space around the former mechanism into a first space and a second space. The first space is on the product feed chute side. The second space is on the transverse sealing mechanism side.

Abstract: Cyclic compounds that selectively inhibit KRAS were found. Moreover, cyclic compounds were found to interact with an amino acid residue specific to KRAS.

Abstract: It was found that a peptide compound that has an N-substituted-?,?-disubstituted amino acid residue at the N-terminus and containing a dipeptide residue in which the N-substituted-?,?-disubstituted amino acid residue and an N-substituted amino acid residue are linked together, can be efficiently produced by linking an N-unsubstituted-?,?-disubstituted amino acid whose amino group is protected with an electron-withdrawing protecting group to an N-substituted amino acid or a peptide compound having an N-substituted amino acid residue at the N-terminus, and then allowing a substituent-introducing agent to act in the presence of a specific base to selectively introduce a substituent to the amino group at the N-terminus.

Abstract: A bagmaking and packaging apparatus forms a sheet-form film into a tubular shape around a tube, which tubular film is transversely sealed after product is introduced therein. The bagmaking and packaging apparatus includes multiple upright support posts that form a frame. The support posts include a first support post group disposed on one side in the left and right direction and a second support post group disposed on the other side. A first support post disposed foremost in the first support post group extends from a low position to a position higher than the transverse sealing mechanism and is disposed forward of a center O of the tube. A second support post disposed foremost in the second support post group extends from a low position to a position higher than the transverse sealing mechanism and is disposed rearward of the center of the tube.

Abstract: Cyclic compounds that selectively inhibit KRAS were found. Moreover, cyclic compounds were found to interact with an amino acid residue specific to KRAS.

Abstract: A bag-making and packaging machine includes a bag-making and packaging section and a film supply section. The film supply section includes a film conveyance section that conveys a starting end portion of a replacement film roll supported by a film roll support portion to a bonding portion. The film conveyance section includes a clamping portion that holds a tape adhering to the starting end portion of the replacement film roll, and a pulling mechanism that pulls a second film held by the clamping portion from the replacement film roll. When the replacement film roll is mounted, the film roll support portion rotates the replacement film roll, and the clamping portion holds the tape of the replacement film roll rotated by the film roll support portion.

Abstract: Methods and apparatus provide for communications between an information processing device operated by a first user, which is connected via a network to another information processing device operated by a second user, where an application executing on the information processing device and generating an application image on a basis of operation information provided by the first user is transmitted to the other information processing device over the network.

Abstract: In a bagmaking-and-packaging apparatus, when switching from bagmaking using a first film to bagmaking using a second film, a first impulse sealer interconnects an end-of-bagmaking film of the first film and a starting end scrap of the second film to form a first interconnected film. A second impulse sealer interconnects a third part on a starting end side of the first F1 and a fourth part of the second film to form a second interconnected film.

Abstract: Cyclic compounds that selectively inhibit KRAS were found. Moreover, cyclic compounds were found to interact with an amino acid residue specific to KRAS.