Abstract: Cyclic compounds that selectively inhibit KRAS were found. Moreover, cyclic compounds were found to interact with an amino acid residue specific to KRAS.

Abstract: An air conditioner system (1) runs in a concentration keeping mode to sequentially repeat a first operation of lowering a target temperature to a first target temperature lower than a predetermined reference temperature and a second operation of raising the target temperature to a second target temperature higher than the reference temperature. The target temperature is gradually raised from the first target temperature to the second target temperature in the second operation. Lowering the target temperature to the first target temperature in the first operation takes shorter time than raising the target temperature to the second target temperature in the second operation.

Abstract: A robot system includes a multi-joint robot arm including a plurality of joints; a robot controller configured or programmed to control movement of the multi-joint robot arm; an interactor configured to interact with a workpiece; a signal output configured to output a moving amount signal based on a moving amount of the interactor arranged on a distal end part of the multi-joint robot arm at a fixed time period; and an interaction controller configured or programmed to control interaction of the interactor with the workpiece based on the moving signal output by the signal output.

Abstract: An exacerbation risk prediction system predicts an exacerbation risk of a patient suffering from a respiratory disease. The exacerbation risk prediction system includes an oxygen concentrator that supplies oxygen to the patient through a cannula, an acquisition unit that acquires first information including biological information of the patient wearing the cannula on exertion and at rest and patient information regarding a disease state, a storage that stores the first information, a prediction unit that predicts the exacerbation risk based on the first information, and a learning unit that learns the first information and an evaluation regarding exacerbation in association with each other. The biological information is at least one of respiratory rate, respiratory waveform, and exhaled gas component amount. The biological information is acquired from the oxygen concentrator. The prediction unit predicts the exacerbation risk by inputting the first information to a learning model created by the learning unit.

Abstract: In order to avoid generation of black unevenness caused by the water intrusion into a liquid crystal display device, there is to provide a liquid crystal display device including a display area and a terminal portion, in which a TFT substrate with an organic passivation film formed and an opposite substrate are adhered to each other by a seal portion and a liquid crystal is enclosed there, wherein in the seal portion of the TFT substrate, a groove-shaped through-hole is formed in the organic passivation film to surround the display area, a water absorption layer formed of the same material in the same process as that of the organic passivation film is formed within the groove-shaped through-hole, and the water absorption layer is not covered with the inorganic insulating film.

Abstract: A steering apparatus includes: a steering shaft coupled to a center of a steering wheel and movable in a front-rear direction of a vehicle; a steering shaft cover covering the steering shaft and allowing the steering shaft to be movable therein; and a protector attached to the steering shaft cover and allowing a part of a wire harness to be inserted and accommodated therein, the wire harness being a plurality of electric wires bundled and routed along the steering shaft. The wire harness positioned in the protector is routed in a state where the plurality of electric wires are unbundled and scattered.

Abstract: A bag-making and packaging machine includes a bag-making and packaging section and a film supply section. The film supply section includes a film conveyance section that conveys a starting end portion of a replacement film roll supported by a film roll support portion to a bonding portion. The film conveyance section includes a clamping portion that holds a tape adhering to the starting end portion of the replacement film roll, and a pulling mechanism that pulls a second film held by the clamping portion from the replacement film roll. When the replacement film roll is mounted, the film roll support portion rotates the replacement film roll, and the clamping portion holds the tape of the replacement film roll rotated by the film roll support portion.

Abstract: A task to be achieved by the present invention is to provide an ink which can form a printed image or the like having color fastness to water at a level where the image will not be removed from the recording medium even when, for example, washed with water, warm water, or the like. Further, another task to be achieved by the invention is to provide an ink which can form a printed image or the like which is unlikely to suffer from color fading even when, for example, washed by an ultrasonic cleaning method or the like that is used for cleaning a stain strongly deposited on clothes or the like. The present invention is directed to an ink containing a polymer (A) having a predetermined structure (a1).

Abstract: An environmental equipment control apparatus controls environmental equipment. The environmental equipment control apparatus includes a grasping unit that grasps physical-and-mental-state information about a physical and mental state of a user, a control unit that changes a control state of the environmental equipment in a case in which the physical-and-mental-state information satisfies a predetermined state condition, and a storage unit that stores correspondence information in which changes in the control state of the environmental equipment are associated with changes in the physical-and-mental-state information of the user grasped by the grasping unit in accordance with the changes in the control state of the environmental equipment.

Abstract: It was found that a binding molecule having features (i) of directly interacting with Asp12 of mutant RAS (G12D), and (ii) of interacting with a Switch 2 region of the mutant RAS (G12D), and having the Switch 2 region of the mutant RAS (G12D) intramolecularly interacting with Asp12 of the mutant RAS (G12D) has high binding selectivity for the mutant RAS (G12D). Such a molecule can be a promising candidate compound for treating and/or preventing a disease related to expression of the mutant RAS (G12D).

Abstract: A bagmaking and packaging apparatus includes a film conveyance mechanism, a former mechanism, a transverse sealing mechanism, and a first partition member. The film conveyance mechanism conveys a film. The former mechanism includes a product feed chute and a former. The product feed chute has a product fed to it. The former forms in a tubular shape the film conveyed by the film conveyance mechanism. The transverse sealing mechanism is disposed under the former mechanism. The transverse sealing mechanism transversely seals the tubular film to make bags containing the product fed from the product feed chute. The first partition member partitions a space around the former mechanism into a first space and a second space. The first space is on the product feed chute side. The second space is on the transverse sealing mechanism side.

Abstract: A bagmaking and packaging apparatus forms a sheet-form film into a tubular shape around a tube, which tubular film is transversely sealed after product is introduced therein. The bagmaking and packaging apparatus includes multiple upright support posts that form a frame. The support posts include a first support post group disposed on one side in the left and right direction and a second support post group disposed on the other side. A first support post disposed foremost in the first support post group extends from a low position to a position higher than the transverse sealing mechanism and is disposed forward of a center O of the tube. A second support post disposed foremost in the second support post group extends from a low position to a position higher than the transverse sealing mechanism and is disposed rearward of the center of the tube.

Abstract: Disclosed are a state monitoring device and a state monitoring method for a ball screw, which enable appropriate collection of data to accurately diagnose the state of the ball screw. The state monitoring device monitors the state of the ball screw having a screw shaft, a nut, and a plurality of balls. The state monitoring device includes a drive control unit for controlling a drive unit (servo motor) to cause the screw shaft and the nut to move relative to each other at a constant speed for one or more reciprocating motions under an unloaded condition, and a data collection unit for collecting, as data, physical quantities related to the ball screw while the drive unit is controlled by the drive control unit.

Abstract: Cyclic compounds and oligopeptide compounds that selectively inhibit KRAS were found. Oligopeptide compounds and non-natural amino acids useful for producing a cyclic compound were also found. Moreover, cyclic compounds and oligopeptide compounds were found to interact with an amino acid residue specific to KRAS.

Abstract: An information processing device, an information processing method, and a program capable of creating a screen more efficiently are provided. An information processing device according to an embodiment includes a display control unit, a reception unit, and a storage control unit. The display control unit displays a display screen for arranging a plurality of components each of which has a predetermined function. The reception unit receives settings of the components designated using the display screen. The storage control unit stores, in a storage device, setting information indicating the settings received. The display control unit displays the display screen on which the components are set in accordance with the setting information.

Abstract: An AUV includes: an underwater vehicle main body configured to sail along an inspection object located in water or on the bottom of the water; an arm extending from the underwater vehicle main body; an inspection tool portion including a contact portion configured to contact the inspection object and an inspection device configured to inspect the inspection object; and a passive joint provided between the arm and the inspection tool portion and configured to allow passive rotation of the inspection tool portion relative to the arm about at least one axis.

Abstract: A film-roll supply device improves replacement of a film roll in a bag-making and packaging machine. A film roll replacement device supplies a first film roll to a bag-making and packaging machine. The film roll replacement device is provided with a holding section and a first driving unit. The holding section receives the first film roll to be supplied to the bag-making and packaging machine. The first driving unit changes an orientation of the holding section between a first orientation used when receiving the first film roll and a second orientation used when supplying the first film roll to the bag-making and packaging machine.

Abstract: In order to avoid generation of black unevenness caused by the water intrusion into a liquid crystal display device, there is to provide a liquid crystal display device including a display area and a terminal portion, in which a TFT substrate with an organic passivation film formed and an opposite substrate are adhered to each other by a seal portion and a liquid crystal is enclosed there, wherein in the seal portion of the TFT substrate, a groove-shaped through-hole is formed in the organic passivation film to surround the display area, a water absorption layer formed of the same material in the same process as that of the organic passivation film is formed within the groove-shaped through-hole, and the water absorption layer is not covered with the inorganic insulating film.

Abstract: A linear motion drive device including a ball screw, a linear motion table driven by the ball screw to move linearly, and an abnormality detection device configured to detect a decrease in a preload applied to the ball screw. The abnormality detection device includes a vibration sensor configured to measure vibration during operation of the ball screw, a calculation processing unit configured to acquire a vibration value of a vibration signal in a specific frequency band among vibration signals measured by the vibration sensor, and an abnormality detection unit configured to determine that a decrease in the preload has occurred in the ball screw when the vibration value is less than a previously determined threshold with respect to a reference value, the reference value being a vibration value in an initial stage of the operation of the ball screw or during a normal operation of the ball screw.

Abstract: A bagmaking and packaging device includes a transverse sealing unit, a first tube member, and a gas flow path member. The first tube member is disposed above the transverse sealing unit and extends in an up and down direction. The first tube member allows a packaging material to become wrapped around it to thereby form the packaging material into a tubular shape. At least part of the gas flow path member is disposed inside the first tube member. The gas flow path member delivers nitrogen into the packaging material formed into the tubular shape. The first tube member includes a cutout portion that extends in the up and down direction. The cutout portion is formed so that the nitrogen can move between a space between the packaging material formed into the tubular shape and the first tube member and the inside space of the first tube member.