Abstract: A method for producing a radioactive metal complex, including a complex forming step of reacting a radioactive metal nuclide with a ligand compound represented by the following formula (1) in a reaction liquid containing water and a buffer to form a radioactive metal complex, the buffer containing one or more water-soluble organic compounds having a sulfo group or a carboxy group, and the reaction liquid being irradiated with microwave while cooling the reaction liquid in the complex forming step. The radioactive metal nuclide is preferably 68Ga, 89Zr, 90Y, 111In, 177Lu, or 225Ac.

Abstract: A method for producing a conjugate of a radioactive metal nuclide and an antibody is provided, and the method includes a step of reacting a radioactive metal nuclide with an antibody conjugated with a ligand compound in a reaction solution containing water to coordinate the radioactive metal nuclide to the ligand compound, and the reaction solution does not contain a pH buffer and has a pH of 2 or more and 10 or less. The radioactive metal nuclide is preferably at least one selected from 68Ga, 89Zr, 90Y, 111In, 177Lu, and 225 Ac. It is also preferable that the radioactive metal nuclide be 89Zr and the reaction solution have a pH of 2 or more and 4 or less.

Abstract: A conjugate, including: an anti-VEGF antibody site-specifically modified with an antibody-modification peptide; and a chelating agent, where a metal radionuclide is chelated to the chelating agent. A radiopharmaceutical including the conjugate as an active ingredient. A method of performing cancer radionuclide therapy, the method including administering the radiopharmaceutical intravenously or orally to a subject in need thereof. A method of diagnosing cancer, the method including administering the radiopharmaceutical intravenously or orally to a subject in need thereof.

Abstract: Described is a stable radiopharmaceutical composition in which the decrease in the radiochemical purity over time is suppressed even in the case where the radioactivity concentration is high immediately after production. The stabilized radiopharmaceutical composition includes a polypeptide labeled with a radionuclide and having a group selected from the group consisting of a thioether group and a thiol group, as an active ingredient, a solubilizing agent having an ethylene glycol group, a solvent including water, and a stabilizer selected from the group consisting of a sulfur-containing amino acid or a salt thereof, a sulfur-containing amino acid derivative or a salt thereof, and a polysaccharide.

Abstract: Provided is a conjugate of a chelating agent chelated with a radionuclide and a deglycosylated antibody, where the chelating agent site-specifically modifies the Fc region of the aforementioned antibody via a linker. The conjugate shows increased accumulation in a tumor and decreased accumulation in normal tissues. These differences in accumulation are associated with a decrease in a risk of side effects.

Abstract: A method for producing a radioactive zirconium complex of the present invention includes a step of reacting a radioactive zirconium ion, a ligand compound containing DOTA or a DOTA derivative, and an additive such as hydroxybenzoic acid and a derivative thereof with one another in a reaction solution to form a radioactive zirconium complex. As the reaction solution, a reaction solution is used in which the amount of radioactivity of the radioactive zirconium ion is 60 MBq or more at the start of the reaction and the amount of radioactivity of the radioactive zirconium ion is 5 MBq or more per 1 nmol of the ligand compound at the start of the reaction.

Abstract: A sole structure includes a thin plate made of an elastic material having a higher elastic modulus than that of a midsole and stacked on a lower side of the midsole and a shock-absorbing body made of a soft-elastic material and abutting on a lower surface of the plate at least in a hindfoot area. The plate extends from a position corresponding to calcaneus of the foot of a shoe wearer at least to a position corresponding to first interphalangeal joint of the foot in a longitudinal direction, is interposed between the midsole and the shock-absorbing body in the hindfoot area, is interposed between the midsole and an outsole in a forefoot area, and is formed such that at least a portion of the plate serves as an exposed portion in which a lower surface is exposed above a grounding surface in a midfoot area.

Abstract: An upper structure includes: an upper body including a stress relaxing portion which is elastically deformable; and a shoelace (a fastening member) attached to the upper body. The stress relaxing portion has: such stretchability that in an elastic range, the stress relaxing portion stretches to become longer when the upper body is pulled with the shoelace than an initial length of the stress relaxing portion; and stress relaxation properties with which the stress relaxing portion relaxes stress with the passage of time from a moment when the upper body is pulled, while remaining in the stretched state.

Abstract: A shoe includes a sole, a shoe upper attached to the sole, and a string member disposed at the sole and the shoe upper such that the string member extends over an area from a forefoot to a hindfoot of a foot, the string member being movable relative to the sole and the shoe upper. The string member is configured such that when the foot is bent at metatarsophalangeal joints and an MP area of the sole is bent and warped in a vertical direction and stretched, a second extension portion is pulled toward a front portion by bending of a first extension portion.

Abstract: An electrostatic sprayer includes a temperature-humidity sensor which detects a humidity and a temperature of a space where the user is present, and a control section which provides control by adjusting an amount of the liquid transferred by a pressure pump and a voltage applied by a high voltage power supply based on the value detected by the temperature-humidity sensor.

Abstract: A shoe 1 of the present invention includes an upper 2 made of a stretchable fabric. The stretchable fabric is integrated with a sole 3 in a state of being stretched. Further, a method of manufacturing the shoe 1 of the present invention is a method of manufacturing a shoe using a stretchable fabric for the upper 2. The method includes steps of: producing an upper pattern using a last having a size smaller than that of the sole 3 as a base; producing the upper 2 with the stretchable fabric being stretched by stretching the upper pattern and fitting the upper pattern onto a last having a size that matches the sole 3; and integrating the upper 2 with the stretchable fabric being stretched with the sole 3.

Abstract: A semiconductor testing circuit of the present invention includes a signal line which is connected to a terminal not to be tested and a plurality of terminals to be tested of a semiconductor device; switch circuits for controlling electrical connection/disconnection between the signal line and the terminals to be tested; and a resistor connected to one end of the signal line. With this configuration, in a test on the AC characteristics of an input signal, a test signal generated by an LSI tester can be inputted to the terminals to be tested through the terminal not to be tested and the signal line by turning on the switch circuits.

Abstract: A shoe 1 of the present invention includes an upper 2 made of a stretchable fabric. The stretchable fabric is integrated with a sole 3 in a state of being stretched. Further, a method of manufacturing the shoe 1 of the present invention is a method of manufacturing a shoe using a stretchable fabric for the upper 2. The method includes steps of: producing an upper pattern using a last having a size smaller than that of the sole 3 as a base; producing the upper 2 with the stretchable fabric being stretched by stretching the upper pattern and fitting the upper pattern onto a last having a size that matches the sole 3; and integrating the upper 2 with the stretchable fabric being stretched with the sole 3.

Abstract: A semiconductor testing circuit of the present invention includes a signal line which is connected to a terminal not to be tested and a plurality of terminals to be tested of a semiconductor device; switch circuits for controlling electrical connection/disconnection between the signal line and the terminals to be tested; and a resistor connected to one end of the signal line. With this configuration, in a test on the AC characteristics of an input signal, a test signal generated by an LSI tester can be inputted to the terminals to be tested through the terminal not to be tested and the signal line by turning on the switch circuits.

Abstract: In testing a large number of semiconductor devices, semiconductor testing equipment of the present invention is provided with combination determining unit 105 that determines the combination of semiconductor devices to be simultaneously tested among semiconductor devices to be tested, on the basis of one of determination results or measured values in separate testing or manufacturing implemented before and stored in a memory 99, and past determination results or measured values stored in the memory 99 in the present testing.

Abstract: In the shipment test of an LSI provided with a high-speed interface circuit, both cost reduction and a high test guarantee level are realized.

Abstract: In a data outputting device, data to be outputted is digitally stored in a memory and is read out when addressed over a predetermined period in a time division multiplex mode with addresses which are provided by a counter in such a manner that the number thereof of addresses provided per predetermined time period corresponds to the number of channels employed, and the data thus read out with the addresses are selected for the channels by a selection circuit, respectively, so that they are outputted separately according to the channels.