Patents by Inventor Satoshi Mitsuyama

Satoshi Mitsuyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10352864
    Abstract: An automatic analyzer includes sample vessels containing samples to be measured and; reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
    Type: Grant
    Filed: July 4, 2011
    Date of Patent: July 16, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kumiko Kamihara, Satoshi Mitsuyama, Tomonori Mimura, Chihiro Manri
  • Patent number: 10281439
    Abstract: In the present invention, differences in liquid feed properties between liquid chromatographic devices are determined, a liquid feed time table that takes these differences into account is acquired by way of system changes, and flow control is performed by a pump. Furthermore, the liquid feed time table after the system changes is divided into a plurality of intervals, and instructions are sent to the pump after approximate calculations are performed. Thus, by efficiently performing system change processes, the same measurement results can be obtained in a plurality of different liquid chromatograph devices, regardless of the differences in liquid feed properties.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: May 7, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Toshimichi Aota, Satoshi Mitsuyama, Masahito Ito, Chihiro Yoshioka, Takaaki Suzuki
  • Patent number: 10203277
    Abstract: There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: February 12, 2019
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Chihiro Manri, Satoshi Mitsuyama, Tomonori Mimura, Kumiko Kamihara
  • Patent number: 9562917
    Abstract: Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: February 7, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Chihiro Manri, Satoshi Mitsuyama, Tomonori Mimura, Kumiko Kamihara
  • Patent number: 9494525
    Abstract: Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2).
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: November 15, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Shinji Tarumi, Chie Yabutani, Akihisa Makino, Chihiro Manri, Satoshi Mitsuyama
  • Patent number: 9488667
    Abstract: To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: November 8, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kumiko Kamihara, Satoshi Mitsuyama, Tomonori Mimura, Chihiro Manri
  • Patent number: 9476893
    Abstract: Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: October 25, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Satoshi Mitsuyama, Chihiro Manri, Tomonori Mimura, Kumiko Kamihara
  • Publication number: 20160216239
    Abstract: In the present invention, differences in liquid feed properties between liquid chromatographic devices are determined, a liquid feed time table that takes these differences into account is acquired by way of system changes, and flow control is performed by a pump. Furthermore, the liquid feed time table after the system changes is divided into a plurality of intervals, and instructions are sent to the pump after approximate calculations are performed. Thus, by efficiently performing system change processes, the same measurement results can be obtained in a plurality of different liquid chromatograph devices, regardless of the differences in liquid feed properties.
    Type: Application
    Filed: November 11, 2013
    Publication date: July 28, 2016
    Inventors: Toshimichi AOTA, Satoshi MITSUYAMA, Masahito ITO, Chihiro YOSHIOKA, Takaaki SUZUKI
  • Patent number: 9310388
    Abstract: In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(?k1*t)+a2*exp(?k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 12, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Kumiko Kamihara, Satoshi Mitsuyama, Tomonori Mimura, Chihiro Manri
  • Patent number: 9239281
    Abstract: An objective is to provide a method and an apparatus for accurately extracting a region of an object particle from a urine particle image obtained by taking an image of urine particles in a urine specimen having varying properties. First, a first object region is extracted using one or more of an R image, a G image, and a B image of a urine particle image taken by an image input optical system configured to input particle images. Then, a density distribution and a size of the first object region of one or more of the R image, the G image, and the B image are calculated. Based on these feature parameters, the first object region is classified into a predetermined number of groups. A second object region is extracted from a local region including the first object region, by using one or more of the R image, the G image, and the B image, depending on each of the groups.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: January 19, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Chihiro Manri, Hideyuki Ban, Satoshi Mitsuyama, Norio Owada
  • Patent number: 9217712
    Abstract: In the event of a suspected abnormality in the device, sample or reagent, a laboratory technician had to examine the abnormal reaction process data item by item, and infer the cause of the abnormality, which took effort and time in some cases. Abnormality judgment is assisted using: indicator computation means that computes an indicator indicating a feature parameter of a given waveform by applying a pre-defined evaluation formula to time series data of photometric values; relative indicator computation means that computes a value indicating a relationship of the indicator of target data to the indicator computed in the past; and indicator display means that simultaneously displays a value computed by the indicator computation means and the value computed by the relative indicator computation means.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 22, 2015
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Satoshi Mitsuyama, Yuki Fukuyama, Hidekatsu Takada, Hideyuki Ban, Tomonori Mimura
  • Publication number: 20150316531
    Abstract: Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2).
    Type: Application
    Filed: November 5, 2013
    Publication date: November 5, 2015
    Inventors: Shinji TARUMI, Chie YABUTANI, Akihisa MAKINO, Chihiro MANRI, Satoshi MITSUYAMA
  • Patent number: 9110019
    Abstract: Disclosed is a flow cytometer using a spectral device and a multi-detector, in which setting of an optimum wavelength band prior to measuring fluorescence intensity in real time is supported. A signal processing unit stores the intensities in multiple wavelength bands, the intensities being obtained by measuring a calibration sample, and the distribution of the intensities is calculated and displayed by each of the wavelength bands.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: August 18, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Satoshi Mitsuyama, Norio Owada, Chihiro Manri, Sadamitsu Aso
  • Patent number: 8831306
    Abstract: At each of mutually different multiple focal positions, focal adjustment parameter values are obtained from images of standard particles made of the same substance. Each focal adjustment parameter value is figured out as any one of the ratio between the density value around the center of the standard particle image and the density value around the outline, the difference therebetween, and the density value around the center. The in-focus position is adjusted on the basis of the relationship between the obtained focal adjustment parameter values and the focal positions. Moreover, on the basis of the relationship between the focal adjustment parameter values and the focal positions, the parameter values are converted into focal positions, and the focal positions and dispersion thereof are used to check the displacement of the in-focus position and the thickness of the sample liquid.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: September 9, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Chihiro Manri, Norio Oowada, Satoshi Mitsuyama
  • Publication number: 20140136123
    Abstract: Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
    Type: Application
    Filed: April 17, 2012
    Publication date: May 15, 2014
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Chihiro Manri, Satoshi Mitsuyama, Tomonori Mimura, Kumiko Kamihara
  • Publication number: 20130317847
    Abstract: The present invention is a system for supporting an evaluation of workflow step items on the basis of a workflow by classifying workflow steps so as to have a common medical-related work by using a medical information database in which a workflow, which is a flow of the medical-related work, and information on respective workflow steps are stored in association with medical information, creating workflow step items having a parent and child identifier identified between a parent department as a client and a child department as a requested party and the medical information, calculating a workflow step evaluation value, which is an evaluation value of the workflow step item on the basis of the clinical indicator of the workflow, and displaying the same on a screen.
    Type: Application
    Filed: December 8, 2011
    Publication date: November 28, 2013
    Applicant: HITACHI, LTD.
    Inventors: Shuntaro Yui, Kumiko Seto, Masayuki Ohta, Satoshi Mitsuyama
  • Publication number: 20130122596
    Abstract: An automatic analyzer includes sample vessels containing samples to be measured and reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
    Type: Application
    Filed: July 4, 2011
    Publication date: May 16, 2013
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Kumiko Kamihara, Satoshi Mitsuyama, Tomonori Mimura, Chihiro Manri
  • Publication number: 20130107256
    Abstract: Disclosed is a flow cytometer using a spectral device and a multi-detector, in which setting of an optimum wavelength band prior to measuring fluorescence intensity in real time is supported. A signal processing unit stores the intensities in multiple wavelength bands, the intensities being obtained by measuring a calibration sample, and the distribution of the intensities is calculated and displayed by each of the wavelength bands.
    Type: Application
    Filed: July 8, 2011
    Publication date: May 2, 2013
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Satoshi Mitsuyama, Norio Owada, Chihiro Manri, Sadamitsu Aso
  • Publication number: 20130103417
    Abstract: Provided is a medical care support system for the sharing and reusing of medical information on the basis of a workflow which is a flow of medical-related services. A workflow step that was executed prior to an ongoing workflow step is selected by using a medical information database which has registered a workflow and information of each workflow step in association with medical information; and information is inputted by medical staff in the ongoing workflow step while the medical information registered in the selected workflow step being referred to; and the medical information being referred to and the inputted information are registered in the medical information database in association with the ongoing workflow step.
    Type: Application
    Filed: June 24, 2011
    Publication date: April 25, 2013
    Applicant: Hitachi, Ltd.
    Inventors: Kumiko Seto, Kikuo Umegaki, Masayuki Ohta, Shuntaro Yui, Satoshi Mitsuyama, Kazuki Matsuzaki, Hajime Sasaki, Takuya Kamiyama, Hisaaki Ochi, Yoshihiko Nagamine, Yuji Oka
  • Publication number: 20130046480
    Abstract: There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
    Type: Application
    Filed: April 5, 2011
    Publication date: February 21, 2013
    Inventors: Chihiro Manri, Satoshi Mitsuyama, Tomonori Mimura, Kumiko Kamihara