Abstract: Methods for the preparation of polymeric films which encase and preserve bioactive agents. In particular, the invention is directed to the preparation of oral thin films containing bioactive proteins or viruses. For example, methods and compositions are disclosed for preservation of rotavirus and antibodies in thin dry films.

Abstract: A manufacturing method of a stainless-steel-made base member includes a first step of forming, from a stainless-steel-made first cup-shaped member held at an inside portion thereof by a holding member, a second cup-shaped member made thinner than the first cup-shaped member by ironing an outside portion of the first cup-shaped member with a ring-shaped member movable in a longitudinal direction of the holding member; a second step of extracting the second cup-shaped member out of the holding member; and a third step of cutting a bottom end portion of the second cup-shaped member with respect to the longitudinal direction. The first cup-shaped member has Vickers hardness of not less than 200 HV0.3/10 or more and not more than 280 HV0.3/10, and the holding member has Vickers hardness which is not less than four times and not more than nine times the Vickers hardness of the first cup-shaped member.

Abstract: A scan asynchronous memory element includes: an asynchronous memory element configured to receive an n-input; and a scan control logic circuit configured to generate an n-bit signal input and the n-input to the asynchronous memory element from a scan input. The scan control logic circuit outputs the signal input when a control signal supplied to the scan control logic circuit has a first bit pattern, the scan control logic circuit outputs the scan input when the control signal has a second bit pattern, and the scan control logic circuit outputs a bit pattern allowing the asynchronous memory element to hold a previous value when the control signal has a bit pattern other than the first and second bit patterns.

Abstract: A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.

Abstract: A method for the selection of pharmaceutically acceptable excipients that allow for the production of highly dispersible powders produced by spray drying.

Abstract: This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.

Abstract: A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.

Abstract: A method for the selection of pharmaceutically acceptable excipients that allow for the production of highly dispersible powders produced by spray drying.

Abstract: This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.

Abstract: This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.

Abstract: This invention provides formulations and methods for stabilizing viruses in liquid and dried formulations. In particular, formulations are provided including Zn2+ cations that stabilize the viability of Rotaviruses. Methods of vaccination include neutralization of gastric contents and administration of the vaccine formulations of the invention.

Abstract: A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.

Abstract: A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.

Abstract: This invention provides compositions and methods for stabilizing a live attenuated virus in dried formulations. In particular, compositions and methods of preparing a dried vaccine are provided that stabilize the viability of live vaccines such as measles and adenovirus at room temperature.

Abstract: This invention provides methods and compositions for stabilizing proteins and vaccines in dried formulations. In particular, a cavitation method and compositions of preparing a dried vaccine are provided that stabilize the viability of live bacteria and live virus vaccines at room temperature.

Abstract: This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.

Abstract: This invention provides formulations and methods for stabilizing viruses in liquid and dried formulations. In particular, formulations are provided including Zn2+ cations that stabilize the viability of Rotaviruses. Methods of vaccination include neutralization of gastric contents and administration of the vaccine formulations of the invention.

Abstract: A test controller 4 has a test plan generating unit 11 for generating a test plan of a data path 2 which is formed to have a fixed control testability in which a test plan constituted by three phases, that is, the propagation of a test vector to a data input, the execution of a test and the propagation of an output response is present for each test object module. Thus, an integrated circuit is capable of supplying a test plan as a time series of a control signal to a control input of a data path, shortening a test execution time and generating the test plan at the normal operation speed of the circuit, thereby carrying out a test at an actual operation speed and an integrated circuit designing method.

Abstract: A three-dimensional shape model indicating a first part is constructed and a three-dimensional shape that works as a transparent screen is disposed thereon continuously. A sight line direction is set and the three-dimensional shape model is displayed after rotated in accordance with the set sight line direction. A first two-dimensional image is constructed in accordance with the sight line direction, and a second two-dimensional image is constructed. The first two-dimensional image and the second two-dimensional image are combined with each other so as to construct a combined two-dimensional image. The combined two-dimensional image is assigned so that the part thereof corresponding to the first two-dimensional image agrees with the three-dimensional shape model, and the combined two-dimensional image is displayed visually.

Abstract: Apparatus for testing integrated circuits containing a controller or other sequential circuit at actual operating speed while minimizing the length of the test sequence and achieving high fault coverage are provided. The states of a state register are assumed controllable and observable, and a set of test patterns is obtained for a combinational circuit not containing said state register. An invalid-state generation logic circuit is added for generating invalid states, which are states contained in the generated test patterns but cannot be set by a normal transition from the reset state. A multiplexer is added for selecting the output of a next-state generation logic circuit or the invalid-state generation logic circuit for input to the state register based on a state transition mode selection signal. Signals corresponding to pseudo-primary outputs during test generation are made observable, and the multiplexer output signal is externally detectable as a state output signal.