Patents by Inventor Satoshi Omura

Satoshi Omura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10202627
    Abstract: An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 12, 2019
    Assignees: The Kitasato Institute, Nagase & Co., Ltd.
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Yuki Inahashi
  • Patent number: 9896456
    Abstract: This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: February 20, 2018
    Assignee: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu
  • Publication number: 20170306371
    Abstract: An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.
    Type: Application
    Filed: February 28, 2017
    Publication date: October 26, 2017
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Yuki Inahashi
  • Patent number: 9771389
    Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (IIa), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: September 26, 2017
    Assignees: THE KITASAKO INSTITUTE, BAYER ANIMAL HEALTH GMBH
    Inventors: Gerd Kleefeld, Robrecht Froyman, Carolin Ludwig, Satoshi Omura, Toshiaki Sunazuka, Hirose Tomoyasu, Sugawara Akihiro, Shiomi Kazuro
  • Patent number: 9737558
    Abstract: The present invention provides a Peyer's patch activator containing a polysaccharide obtained from sugar cane as an active ingredient, wherein the polysaccharide contains ?-glucan as a main component and has a peak molecular weight within a range of 720,000 to 1,080,000, with a proportion of glucose in all component sugars being 80% or more, and proportions of nonreducing terminal glucose and ?-1,6-linked glucose being 20 to 30% and 15 to 25%, respectively.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: August 22, 2017
    Assignees: Mitsui Sugar Co., Ltd., The Kitasato Institute
    Inventors: Haruki Yamada, Hiroaki Kiyohara, Kazuhiko Otoguro, Aki Ishiyama, Masato Iwatsuki, Satoshi Omura, Masami Mizu, Toshikazu Kawai, Jun Kashimura, Kenji Koge
  • Publication number: 20170215422
    Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.
    Type: Application
    Filed: April 17, 2017
    Publication date: August 3, 2017
    Inventors: Masaaki MITOMI, Masayo SAKAI, Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Satoshi OMURA, Toshiaki SUNAZUKA, Tomoyasu HIROSE, Kazuro SHIOMI, Rokuro MASUMA
  • Publication number: 20170204114
    Abstract: This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2.
    Type: Application
    Filed: June 18, 2015
    Publication date: July 20, 2017
    Applicant: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu
  • Publication number: 20160108077
    Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (IIa), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.
    Type: Application
    Filed: May 23, 2014
    Publication date: April 21, 2016
    Applicants: THE KITASAKO INSTITUTE, BAYER ANIMAL HEALTH GMBH
    Inventors: Gerd KLEEFELD, Robrecht FROYMAN, Carolin LUDWIG, Satoshi OMURA, Toshiaki SUNAZUKA, Hirose TOMOYASU, Sugawara AKIHIRO, Shiomi KAZURO
  • Publication number: 20150344404
    Abstract: The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents, R1 and R4, which are the same or different, represent a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group, R2 and R3, which are the same or different, represent a hydrogen atom, a carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, or a group represented by —C (?R9)—R10), a pharmaceutical composition for treatment or prophylaxis of diseases or disorders that pyruvate dehydrogenase kinase relates to its development or aggravation, and a cosmetic composition, and the like.
    Type: Application
    Filed: December 26, 2013
    Publication date: December 3, 2015
    Inventors: Satoshi OMURA, Hirofumi NAKANO, Kenzaburo YAMAJI, Tsuyoshi YAMAMOTO, Hiroshi KIDO, Kazuhiko YAMANE, Toshiaki SUNAZUKA, Tomoyasu HIROSE
  • Publication number: 20150335610
    Abstract: The purpose of the present invention is to provide a therapeutic agent or preventive agent for exacerbation of influenza, specifically to provide a novel pyruvate dehydrogenase kinase 4 (PDK4) inhibitor. The present invention relates to a PDK4 inhibitor, medical composition or cosmetic composition containing as the active ingredient a compound represented by any one of the following general formulas (I) through (III) and a pharmaceutically acceptable ester derivative thereof, or a pharmaceutically acceptable salt of the same.
    Type: Application
    Filed: October 17, 2013
    Publication date: November 26, 2015
    Applicants: THE UNIVERSITY OF TOKUSHIMA, THE KITASATO INSTITUTE
    Inventors: Satoshi OMURA, Hirofumi NAKANO, Kenzaburo YAMAJI, Tsuyoshi YAMAMOTO, Hiroshi KIDO, Junji CHIDA, Kazuhiko YAMANE
  • Patent number: 9187492
    Abstract: A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: November 17, 2015
    Assignee: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Tohru Nagamitsu, Daisuke Matsuda, Taichi Ohshiro, Masaki Ohtawa, Satoshi Omura
  • Publication number: 20150258131
    Abstract: The present invention provides a Peyer's patch activator containing a polysaccharide obtained from sugar cane as an active ingredient, wherein the polysaccharide contains ?-glucan as a main component and has a peak molecular weight within a range of 720,000 to 1,080,000, with a proportion of glucose in all component sugars being 80% or more, and proportions of nonreducing terminal glucose and ?-1,6-linked glucose being 20 to 30% and 15 to 25%, respectively.
    Type: Application
    Filed: September 18, 2013
    Publication date: September 17, 2015
    Applicants: The Kitakaso Institute, Mitsui Sugar Co., Ltd.
    Inventors: Haruki Yamada, Hiroaki Kiyohara, Kazuhiko Otoguro, Aki Ishiyama, Masato Iwatsuki, Satoshi Omura, Masami Mizu, Toshikazu Kawai, Jun Kashimura, Kenji Koge
  • Publication number: 20150166608
    Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.
    Type: Application
    Filed: June 13, 2013
    Publication date: June 18, 2015
    Inventors: Masaaki Mitomi, Masayo Sakai, Ryo Horikoshi, Yasumichi Onozaki, Satoshi Nakamura, Satoshi Omura, Toshiaki Sunazuka, Tomoyasu Hirose, Kazuro Shiomi, Rokuro Masuma
  • Patent number: 9000194
    Abstract: The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. K10-0216 strain that produces said compound.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: April 7, 2015
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
  • Publication number: 20140349954
    Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (I); a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.
    Type: Application
    Filed: November 21, 2012
    Publication date: November 27, 2014
    Inventors: Gerd Kleefeld, Robrecht Froyman, Julia Charlotte Dörner, Carolin Ludwig, Satoshi Omura, Sunazuka Toshiaki, Hirose Tomoyasu, Sugawara Akihiro, Shiomi Kazuro
  • Patent number: 8822501
    Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: September 2, 2014
    Assignees: Meiji Seika Pharma Co., Ltd., The Kitasato Institute
    Inventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
  • Publication number: 20140206889
    Abstract: [Problem] The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. [Solution] The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. Kl0-0216 strain that produces said compound.
    Type: Application
    Filed: August 31, 2012
    Publication date: July 24, 2014
    Applicant: THE KITASATO INSTITUTE
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
  • Patent number: 8519128
    Abstract: The present invention is a compound having the general formula (I), (II), or (III) or a pharmacologically acceptable salt, solvate, or hydrate thereof, and a pharmaceutical composition containing such a compound, or its pharmacologically acceptable ester, or other pharmacologically acceptable derivative thereof as an active ingredient. The compound has an excellent ACAT 2-inhibiting activity by a mechanism different from that of a statin drug and is useful as a therapeutic or prophylactic agent for obesity, adiposis, hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, and arteriosclerosis, as well as obesity-derived hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, arteriosclerosis, and hypertension.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: August 27, 2013
    Assignee: The Kitasato Institute
    Inventors: Hiroshi Tomoda, Tohru Nagamitsu, Satoshi Omura
  • Publication number: 20130131091
    Abstract: The present invention provides a composition for use as a harmful organism control agent comprising as an active ingredient one or more of compounds represented by formula (I) or salts thereof and an agriculturally or zootechnically acceptable carrier. wherein Het represents pyridyl; X represents an oxygen atom; R1, R2, R3, R7, R10a, R10b, R11, and R12 represent a hydrogen atom; R4, R5, and R6 represent a hydrogen atom, hydroxyl, optionally substituted C1-18 alkylcarbonyloxy, optionally substituted C1-18 alkylsulfonyloxy, optionally substituted arylcarbonyloxy, C1-6 alkyloxy-C1-6 alkyloxy, C1-6 alkyloxy-C1-6 alkyloxy-C1-6 alkyloxy; R8 represents a hydrogen atom; and R13a, R13b, and R13c represent methyl.
    Type: Application
    Filed: May 23, 2011
    Publication date: May 23, 2013
    Inventors: Kimihiko Goto, Ryo Horikoshi, Kazuhiko Oyama, Yoshimasa Fukuda, Nozomu Nakanishi, Masato Tani, Nobuto Minowa, Masaaki Mitomi, Satoshi Omura, Toshiaki Sunazuka, Hiroshi Tomoda
  • Publication number: 20130085163
    Abstract: A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —13—O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
    Type: Application
    Filed: March 25, 2011
    Publication date: April 4, 2013
    Applicant: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE
    Inventors: Hiroshi Tomoda, Tohru Nagamitsu, Daisuke Matsuda, Taichi Ohshiro, Masaki Ohtawa, Satoshi Omura