Patents by Inventor Satoshi Yomoda
Satoshi Yomoda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11376235Abstract: To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1? released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.Type: GrantFiled: February 8, 2017Date of Patent: July 5, 2022Assignee: KRACIE HOLDINGS, LTD.Inventors: Shimpei Watanabe, Ayako Arai, Yuichi Takajo, Satoshi Inamasu, Satoshi Yomoda, Akiko Ohno, Yuko Kitahara, Taisaku Kanatani
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Publication number: 20190099400Abstract: To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1? released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.Type: ApplicationFiled: February 8, 2017Publication date: April 4, 2019Applicant: KRACIE HOLDINGS, LTD.Inventors: Shimpei WATANABE, Ayako ARAI, Yuichi TAKAJO, Satoshi INAMASU, Satoshi YOMODA, Akiko OHNO, Yuko KITAHARA, Taisaku KANATANI
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Patent number: 9907852Abstract: The purpose of the present invention is to provide an anticancer agent for potentiating an antitumor effect, alleviating side effects, and further extending the survival rate by concomitant use with a component having an anticancer effect. An anticancer agent combining arctigenin and a component other than arctigenin that has an anticancer effect, in which the anticancer agent may be a combination drug or may be a kit configured from a formulation containing arctigenin and a formulation containing a component that has an anticancer effect, and the concomitant use of arctigenin and the component having an anticancer effect more strongly inhibits tumor growth and reduces the proportion of cancer stem cells in the tumor, making it possible to extend the total survival time and to alleviate side effects caused by the component having an anticancer effect.Type: GrantFiled: April 10, 2015Date of Patent: March 6, 2018Assignees: National University Corporation University of Toyama, Kracie Pharma, Ltd., National Cancer Center, Tokyo University of Science FoundationInventors: Hiroyasu Esumi, Masafumi Ikeda, Katsuya Tsuchihara, Shigeki Chiba, Satoshi Yomoda, Takanori Kawashima, Toshiki Okubo, Yasuhiro Tezuka, Kenta Murata
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Patent number: 9700572Abstract: The present invention is intended to provide a novel anticancer agent which is effective to a cancer. After administering an agent prepared using burdock fruit extract to a pancreas cancer patient so that a dose of arctigenin was 100 mg or more per day, the tumor reducing effect was observed, and, in addition, lowering of tumor markers was confirmed. The present invention provides an anticancer agent containing arctigenin, wherein a dose of the arctigenin is 100 mg or more per day. In addition, the present invention provides the anticancer agent containing arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3.Type: GrantFiled: September 24, 2014Date of Patent: July 11, 2017Assignees: National Cancer Center, Kracie Pharma, Ltd., National University Corporation University of ToyamaInventors: Hiroyasu Esumi, Masafumi Ikeda, Chika Miyoshi, Shigetoshi Kadota, Toshiki Okubo, Satoshi Yomoda, Takafumi Fuse, Takanori Kawashima, Shigeki Chiba
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Patent number: 9586921Abstract: PROBLEM TO BE SOLVED A burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer. SOLUTION The burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.Type: GrantFiled: February 5, 2010Date of Patent: March 7, 2017Assignees: Kracie Pharma, Ltd., Japan as Represented by President of National Cancer Center, National University Corporation University of ToyamaInventors: Keiichi Yamamoto, Toshiki Okubo, Satoshi Yomoda, Hiroyasu Esumi, Chika Miyoshi, Shigetoshi Kadota
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Publication number: 20170028065Abstract: The purpose of the present invention is to provide an anticancer agent for potentiating an antitumor effect, alleviating side effects, and further extending the survival rate by concomitant use with a component having an anticancer effect. An anticancer agent combining arctigenin and a component other than arctigenin that has an anticancer effect, in which the anticancer agent may be a combination drug or may be a kit configured from a formulation containing arctigenin and a formulation containing a component that has an anticancer effect, and the concomitant use of arctigenin and the component having an anticancer effect more strongly inhibits tumor growth and reduces the proportion of cancer stem cells in the tumor, making it possible to extend the total survival time and to alleviate side effects caused by the component having an anticancer effect.Type: ApplicationFiled: April 10, 2015Publication date: February 2, 2017Applicants: National University Corporation University of Toyama, Kracie Pharma, Ltd., National Cancer Center, Tokyo University of Science FoundationInventors: Hiroyasu Esumi, Kouji IKEDA, Katsuya TSUCHIHARA, Shigeki Chiba, Satoshi Yomoda, Takanori Kawashima, Toshiki Okubo, Yasuhiro TEZUKA, Kenta MURATA
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Publication number: 20150196576Abstract: The present invention is intended to provide a novel anticancer agent which is effective to a cancer. After administering an agent prepared using burdock fruit extract to a pancreas cancer patient so that a dose of arctigenin was 100 mg or more per day, the tumor reducing effect was observed, and, in addition, lowering of tumor markers was confirmed. The present invention provides an anticancer agent containing arctigenin, wherein a dose of the arctigenin is 100 mg or more per day. In addition, the present invention provides the anticancer agent containing arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3.Type: ApplicationFiled: September 24, 2014Publication date: July 16, 2015Inventors: Hiroyasu ESUMI, Masafumi IKEDA, Chika MIYOSHI, Shigetoshi KADOTA, Toshiki OKUBO, Satoshi YOMODA, Takafumi FUSE, Takanori KAWASHIMA, Shigeki CHIBA
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Patent number: 9072718Abstract: PROBLEM TO BE SOLVED The present invention is intended to provide a burdock fruit extract comprising arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of approximately 1:1. SOLUTION A method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20° C. to 50° C. Also provided is the method further including a step of extracting an extract comprising arctigenin and arctiin by adding an organic solvent and heating to reflux.Type: GrantFiled: March 22, 2013Date of Patent: July 7, 2015Assignees: National University Corporation University of Toyama, Kracie Pharma, Ltd., National Cancer CenterInventors: Toshiki Okubo, Satoshi Yomoda, Takafumi Fuse, Takanori Kawashima, Hiroyasu Esumi, Chika Miyoshi, Shigetoshi Kadota
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Publication number: 20120029070Abstract: PROBLEM TO BE SOLVED A burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer. SOLUTION The burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.Type: ApplicationFiled: February 5, 2010Publication date: February 2, 2012Applicant: Kracie Pharma, Ltd.Inventors: Keiichi Yamamoto, Toshiki Okubo, Satoshi Yomoda, Hiroyasu Esumi, Chika Miyoshi, Shigetoshi Kadota
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Patent number: 7550436Abstract: A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a food-origin protein with a protease and has an activity of inhibiting angiotensin converting enzyme, and one or more electrolyte excretion promoters selected from chitosan, alginic acid or a salt thereof, and further relates to a food containing the same. Said composition has excellent inhibitory activity to rise of blood pressure by synergistic effects of both components.Type: GrantFiled: May 8, 2001Date of Patent: June 23, 2009Assignee: Kracie Pharma, Ltd.Inventors: Ryuji Takahashi, Satoshi Yomoda
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Publication number: 20040076690Abstract: The present invention relates to compositions comprising compounds that induce weight and fat loss and compounds that mask the bitter and harsh taste of the composition. The invention further relates to a food, beverage, dietary supplement, medical food, or pet food comprising compounds that induce weight loss and compounds that mask the bitter and harsh taste of the product. The invention is further related to methods of reducing or controlling weight by administering such compositions. Further provided are cosmetic sheets for topical administration of compositions for inducing weight and fat loss.Type: ApplicationFiled: April 30, 2003Publication date: April 22, 2004Applicants: Kanebo, Ltd., Takasago International Corporation, Takasago International CorporationInventors: Takeshi Ikemoto, Hiroyuki Nishio, Mariko Hara, Masato Saito, Satoshi Yomoda, Koichi Ogata, Kenya Ishida, Tamami Sato, Hiromi Matsumoto, Toshiyuki Hamasaki, Yoshiko Nihei, Naoko Ozawa, Charles H. Manley
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Publication number: 20030144179Abstract: Compositions containing peptide(s) and electrolyte excretion promoter(s) characterized by comprising a peptide or a peptide mixture, which is obtained by digesting cow's milk-origin protein with a protease and has an activity of inhibiting angiotensin converting enzyme, and one or more electrolyte excretion promoters selected from among chitosan, alginic acid and salts thereof. Owing to the synergistic effects of the components, these compositions exert an excellent effect of inhibiting increase in blood pressure.Type: ApplicationFiled: October 22, 2002Publication date: July 31, 2003Inventors: Ryuji Takahashi, Satoshi Yomoda