Patents by Inventor Saturo Kuhara

Saturo Kuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biological discovery using gene regulatory networks generated from multiple-disruption expression libraries
    Patent number: 7430475
    Abstract: Embodiments of this invention include application of new inferential methods to analysis of complex biological information, including gene networks. In some embodiments, disruptant data and/or drug induction/inhibition data are obtained simultaneously for a number of genes in an organism. New methods include modifications of Boolean inferential methods and application of those methods to determining relationships between expressed genes in organisms. Additional new methods include modifications of Bayesian inferential methods and application of those methods to determining cause and effect relationships between expressed genes, and in some embodiments, for determining upstream effectors of regulated genes. Additional modifications of Bayesian methods include use of heterogeneous variance and different curve fitting methods, including spline functions, to improve estimation of graphs of networks of expressed genes.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: September 30, 2008
    Assignee: GNI KK
    Inventors: Seiyo Imoto, Takao Goto, Satoru Miyano, Kosuke Tashiro, Michiel de Hoon, Christopher J. Savoie, Saturo Kuhara
  • Biological discovery using gene regulatory networks generated from multiple-disruption expression libraries
    Publication number: 20030219764
    Abstract: Embodiments of this invention include application of new inferential methods to analysis of complex biological information, including gene networks. In some embodiments, disruptant data and/or drug induction/inhibition data are obtained simultaneously for a number of genes in an organism. New methods include modifications of Boolean inferential methods and application of those methods to determining relationships between expressed genes in organisms. Additional new methods include modifications of Bayesian inferential methods and application of those methods to determining cause and effect relationships between expressed genes, and in some embodiments, for determining upstream effectors of regulated genes. Additional modifications of Bayesian methods include use of heterogeneous variance and different curve fitting methods, including spline functions, to improve estimation of graphs of networks of expressed genes.
    Type: Application
    Filed: September 26, 2002
    Publication date: November 27, 2003
    Inventors: Seiya Imoto, Takao Goto, Satoru Miyano, Kosuke Tashiro, Michiel J.L de Hoon, Christopher J. Savoie, Saturo Kuhara