Patents by Inventor Saul Brusilow

Saul Brusilow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives
    Patent number: 7557144
    Abstract: The present invention generally relates to diseases or conditions modulated by undesired protein expression. In one aspect, the methods provide for administration to a mammal, particularly a human, of a therapeutically effective amount of a carbocyclic aryl compound capable of modulating that undesired protein expression. Assays for detecting compounds having desired therapeutic capacity are also provided.
    Type: Grant
    Filed: March 11, 2000
    Date of Patent: July 7, 2009
    Assignee: The Johns Hopkins University
    Inventors: Pamela L. Zeitlin, Saul Brusilow
  • Dosage form of L-Methionine S-Sulfoximine
    Patent number: 6875792
    Abstract: Methods for the treatment of both diseases susceptible to the inhibition of mammalian glutamine synthetase and progressive hyperammonemic encephalopathy comprising administering L-methionine S-sulfoxime at a dose not to exceed 10 mg/kg body weight are disclosed. Preferably, the dose should not exceed 8 mg/kg; more preferably, the dose should not exceed 5 mg/kg; most preferably, the dose should not exceed 2.5 mg/kg.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: April 5, 2005
    Assignee: MSO Pharma LLC
    Inventors: Saul Brusilow, Richard J. Traystman, Raymond C. Koehler
  • Novel dosage form of L-Methionine S-Sulfoximine
    Publication number: 20030144357
    Abstract: A novel dosage form of L-Methionine S-Sulfoximine for the treatment of diseases and conditions susceptible to the inhibition of glutamine synthetase is disclosed. The novel dosage form should not exceed 10 mg/kg by body weight over a one week period, and preferably should not exceed 8 mg/kg, and more preferably should not exceed 5 mg/kg, and most preferably should not exceed 2.5 mg/kg.
    Type: Application
    Filed: January 31, 2002
    Publication date: July 31, 2003
    Inventors: Saul Brusilow, Richard J. Traystman, Raymond C. Koehler