Patents by Inventor Saulius Vainauskas

Saulius Vainauskas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccinia Capping Enzyme Compositions and Methods
    Publication number: 20230416701
    Abstract: The present disclosure relates, according to some embodiments, to compositions, methods, and/or kits for producing vaccinia capping enzyme. For example, active, heterodimers of vaccinia capping enzyme may be produced as fusions comprising D1 and D12 subunits. Vaccinia capping enzyme fusion proteins may further comprise a linker.
    Type: Application
    Filed: September 7, 2023
    Publication date: December 28, 2023
    Applicant: New England Biolabs, Inc.
    Inventors: Saulius Vainauskas, Siu-hong Chan, Christopher H. Taron
  • Vaccinia capping enzyme compositions and methods
    Patent number: 11788074
    Abstract: The present disclosure relates, according to some embodiments, to compositions, methods, and/or kits for producing vaccinia capping enzyme. For example, active, heterodimers of vaccinia capping enzyme may be produced as fusions comprising D1 and D12 subunits. Vaccinia capping enzyme fusion proteins may further comprise a linker.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: October 17, 2023
    Assignee: New England Biolabs, Inc.
    Inventors: Saulius Vainauskas, Siu-Hong Chan, Christopher H. Taron
  • Vaccinia Capping Enzyme Compositions and Methods
    Publication number: 20210395706
    Abstract: The present disclosure relates, according to some embodiments, to compositions, methods, and/or kits for producing vaccinia capping enzyme. For example, active, heterodimers of vaccinia capping enzyme may be produced as fusions comprising D1 and D12 subunits. Vaccinia capping enzyme fusion proteins may further comprise a linker.
    Type: Application
    Filed: June 15, 2021
    Publication date: December 23, 2021
    Applicant: New England Biolabs, Inc.
    Inventors: Saulius Vainauskas, Siu-hong Chan, Christopher H. Taron
  • Cleavage of fucose in N-glycans
    Patent number: 10260056
    Abstract: Provided herein is an ?-fucosidase that can cleave a conjugate comprising an N-glycan and a label where the label is added by amine reactive chemistry. The ?-fucosidase also has an accelerated reaction time using Schiff base labeled N-glycans compared with bovine kidney fucosidase. A reaction mix, enzyme mix and kit comprising the ?-fucosidase are provided, as well as a method for analyzing glycoproteins. The ?-fucosidase finds particular use in analyzing the N-glycans of therapeutic glycoproteins.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: April 16, 2019
    Assignee: New England Biolabs, Inc.
    Inventors: Christopher H. Taron, Saulius Vainauskas, Xiaofeng Shi
  • Cleavage of Fucose in N-Glycans
    Publication number: 20180265910
    Abstract: Provided herein is an ?-fucosidase that can cleave a conjugate comprising an N-glycan and a label where the label is added by amine reactive chemistry. The ?-fucosidase also has an accelerated reaction time using Schiff base labeled N-glycans compared with BKF. A reaction mix, enzyme mix and kit comprising the ?-fucosidase are provided, as well as a method for analyzing glycoproteins. The ?-fucosidase finds particular use in analyzing the N-glycans of therapeutic glycoproteins.
    Type: Application
    Filed: March 17, 2017
    Publication date: September 20, 2018
    Applicant: New England Biolabs, Inc.
    Inventors: Christopher H. Taron, Saulius Vainauskas, Xiaofeng Shi
  • Cleavage of Fucose in N-Glycans
    Publication number: 20180265854
    Abstract: Provided herein is an ?-fucosidase that can cleave a conjugate comprising an N-glycan and a label where the label is added by amine reactive chemistry. The ?-fucosidase also has an accelerated reaction time using Schiff base labeled N-glycans compared with bovine kidney fucosidase. A reaction mix, enzyme mix and kit comprising the ?-fucosidase are provided, as well as a method for analyzing glycoproteins. The ?-fucosidase finds particular use in analyzing the N-glycans of therapeutic glycoproteins.
    Type: Application
    Filed: February 12, 2018
    Publication date: September 20, 2018
    Applicant: New England Biolabs, Inc.
    Inventors: Christopher H. Taron, Saulius Vainauskas, Xiaofeng Shi
  • Methods and compositions for discrimination between cytosine and modifications thereof, and for methylome analysis
    Patent number: 9896726
    Abstract: Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: February 20, 2018
    Assignee: New England Biolabs, Inc.
    Inventors: Romualdas Vaisvila, Heidi E. Johnson, Saulius Vainauskas, Theodore B. Davis
  • Methods and Compositions for Discrimination Between Cytosine and Modifications Thereof, and for Methylome Analysis
    Publication number: 20150322506
    Abstract: Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Romualdas Vaisvila, Heidi E. Johnson, Saulius Vainauskas, Theodore B. Davis
  • Methods and compositions for discrimination between cytosine and modifications thereof and for methylome analysis
    Patent number: 9121061
    Abstract: Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 1, 2015
    Assignee: New England Biolabs, Inc.
    Inventors: Romualdas Vaisvila, Heidi Erika Johnson, Saulius Vainauskas, Theodore B. Davis
  • Methods and Compositions for Discrimination Between Cytosine and Modifications Thereof and for Methylome Analysis
    Publication number: 20130244237
    Abstract: Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: NEW ENGLAND BIOLABS, INC.
    Inventors: Romualdas Vaisvila, Heidi Erika Johnson, Saulius Vainauskas