Abstract: Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5?untranslated region (5?UTR). We have investigated whether small RNA molecules corresponding to the different stem-loop (SL) domains of the HCV IRES, when introduced in trans, can bind to the cellular proteins and antagonize their binding to the viral IRES, thereby inhibiting HCV IRES-mediated translation. We have found that an RNA molecule corresponding to SL III of the HCV IRES could efficiently inhibit HCV IRES-mediated translation in a dose-dependent manner without affecting cap-dependent translation. The SL III RNA was also found to bind efficiently to most of the cellular proteins which interacted with the HCV 5?UTR. A smaller RNA corresponding to SL e+f of domain III also strongly and selectively inhibited HCV IRES-mediated translation.

Abstract: A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed.

Abstract: A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed.

Abstract: Disclosed herein is a small 7 amino-acid peptide, corresponding to the C terminus of RRM2 of the human La protein that binds to the IRES element of hepatitis C virus RNA and its derivatives. This disclosure demonstrates that this 7-mer interacts with the HCV IRES element both in vitro and in vivo and can compete against cellular La protein in binding to the HCV RNA. It is also shown here that this 7-mer peptide is able to inhibit HCV-IRES mediated translation in vivo which, in turn, leads to decreased viral replication.

Abstract: A service appliance is installed between a production server running a service applications and service users. Upon being connected with the production server, the service appliance contacts the production server and/or service application and automatically replicates the service data from the service application. As additional service data is added to or modified by the service application of the production server, the service appliance automatically updates its replica of the data. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability using the replica of the data. When an operational production server is connected with the service appliance, the service appliance can automatically copy its service data to the service application of the operational production server. The operational production server can be the same as the original production server or a new production server.

Abstract: A service appliance is installed between production servers running service applications and service users. The production servers and their service applications provide services to the service users. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability. To maintain transparency to service users and service applications, service users are located on a first network and production servers are located on a second network. The service appliance assumes the addresses of the service users on the second network and the addresses of the production servers on the first network. Thus, the service appliance obtains all network traffic sent between the production server and service users. While the service application is operating correctly, the service appliance forwards network traffic between the two networks using various network layers.

Abstract: A service appliance is installed between production servers running service applications and service users. The production servers and their service applications provide services to the service users. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability. To maintain transparency to service users and service applications, service users are located on a first network and production servers are located on a second network. The service appliance assumes the addresses of the service users on the second network and the addresses of the production servers on the first network. Thus, the service appliance obtains all network traffic sent between the production server and service users. While the service application is operating correctly, the service appliance forwards network traffic between the two networks using various network layers.

Abstract: A service appliance is installed between a production server running a service applications and service users. Upon being connected with the production server, the service appliance contacts the production server and/or service application and automatically replicates the service data from the service application. As additional service data is added to or modified by the service application of the production server, the service appliance automatically updates its replica of the data. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability using the replica of the data. When an operational production server is connected with the service appliance, the service appliance can automatically copy its service data to the service application of the operational production server. The operational production server can be the same as the original production server or a new production server.

Abstract: Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5?untranslated region (5?UTR). We have investigated whether small RNA molecules corresponding to the different stem-loop (SL) domains of the HCV IRES, when introduced in trans, can bind to the cellular proteins and antagonize their binding to the viral IRES, thereby inhibiting HCV IRES-mediated translation. We have found that an RNA molecule corresponding to SL III of the HCV IRES could efficiently inhibit HCV IRES-mediated translation in a dose-dependent manner without affecting cap-dependent translation. The SL III RNA was also found to bind efficiently to most of the cellular proteins which interacted with the HCV 5?UTR. A smaller RNA corresponding to SL e+f of domain III also strongly and selectively inhibited HCV IRES-mediated translation.

Abstract: A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed.

Abstract: A service appliance is installed between a production server running a service applications and service users. Upon being connected with the production server, the service appliance contacts the production server and/or service application and automatically replicates the service data from the service application. As additional service data is added to or modified by the service application of the production server, the service appliance automatically updates its replica of the data. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availibility using the replica of the data. When an operational production server is connected with the service appliance, the service appliance can automatically copy its service data to the service application of the operational production server. The operational production server can be the same as the original production server or a new production server.

Abstract: A service appliance is installed between production servers running service applications and service users. The production servers and their service applications provide services to the service users. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability. To maintain transparency to service users and service applications, service users are located on a first network and production servers are located on a second network. The service appliance assumes the addresses of the service users on the second network and the addresses of the production servers on the first network. Thus, the service appliance obtains all network traffic sent between the production server and service users. While the service application is operating correctly, the service appliance forwards network traffic between the two networks using various network layers.

Abstract: A service appliance is installed between production servers running service applications and service users. The production servers and their service applications provide services to the service users. The service appliance replicates the service data of service applications and monitors the service application. If the service appliance detects that the service application has failed or is about to fail, the service appliance takes control of the service. Using the replica of the service data, the service appliance responds to service users in essentially the same manner as a fully operational service application and production server and updates its replica of the service data as needed. When the service appliance detects that the service application has resumed functioning, the service appliance automatically synchronizes the data of the service application of the production server with the service appliance's data and returns control of the service to the service application and its production server.

Abstract: A service appliance can be installed between one or more production servers running service applications and service users. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availibility. The service appliance is capable of providing the service using a service application that is differently configured or even a different application than the service applications of the production server. The service appliance may include hardware and/or software to monitor, repair, maintain, and update the service application and other associated software applications and components of service appliance. The service appliance may be configured to have a locked state that prevents local running of additional applications other than those provided for prior to entering the locked state, limiting local and remote user administration of and operational control of the operating system and service application.

Abstract: System and method for performing message logging for networked applications running on application servers. The application server may run a process referred to as a “logging service” that accepts requests from client processes to log messages regarding various types of runtime events or conditions. These client processes may include any of various types of processes, such as modules or components running on the application server. Any of various types of information may be recorded when a message is logged. For example, the information may include the date and time the message was created, the type of message, such as a warning message, an error message, etc., the message text to be recorded, the ID of a service or component requesting the message to be logged, or any of various other types of information. The logging service may also be operable to handle low-storage-space or out-of-storage space conditions.

Abstract: System and method for enabling application server request failover. For each application server request to be performed by a client computer, a requesting thread may be operable to utilize a custom wire-level communication protocol. Request failure detection mechanisms may be built into the custom wire-level communication protocol so that a requesting thread detects a failed request much sooner than if the thread utilized a standard communication protocol and relied on the client computer operating system for notification of failed requests. After sending a request to an application server, a requesting thread may be operable to “sleep” and then periodically wake up to poll the application server computer to determine whether the request has failed. If the requesting thread receives a response from the application server computer indicating that the request is not currently being processed, then the requesting thread may re-send the request.

Abstract: A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed.

Abstract: Peptides having specific patterns of acidic and aromatic amino acids which inhibit viral infections are described. The peptides contain 15-18 amino acids and may be administered as such, in combination with additional antiviral agents and/or in the form of nucleotide sequences encoding them.

Abstract: Peptides and RNA oligonucleotides and methods of use for the inhibition of translation of an mRNA, which is initiated at an internal ribosome entry site of the mRNA and requires binding of a protein factor to that site, are disclosed. Peptides comprising the La autoantigen binding domain (LAP) are disclosed. LAP peptides alone or in combination with inhibitor RNA oligonucleotides (IRNA) may be used as antiviral agents to inhibit internal ribosome entry site (IRES) mediated viral replication.

Abstract: A method to inhibit translation of an mRNA, which is intitiated at an internal ribosome entry site of the mRNA and requires binding of a protein factor to that site, is disclosed. The method comprises a step of providing, in an in vitro, or in vivo system that is capable of translating the mNRA, an inhibitory effective amount of a molecule that selectively binds to the protein factor, thereby preventing that factor from binding to the mNRA. The inhibitor molecule is an RNA oligonucleotide consisting of less than 35 nucleotides or a structural mimic of such an RNA oligonucleotide.