Abstract: Methods and systems for personalized trust recommendation based on a dynamic trust model. In an example embodiment, a trust framework can be derived from a set of use-case specific factors. Invasive data and non-invasive data can be collected from a user (or a group of users) based on activity data and profile data associated with the user. A dynamic trust profile can be created (or learned) based on the invasive data and the non-invasive data collected from the user. A recommended level of trustworthiness can be then provided to the user respect to a particular situation and/or entity (e.g. other users) within the trust framework based on the dynamic trust profile of the user and which is personalized for the user.

Abstract: The present invention relates to a stable ready to use and powder for oral suspension dosage forms of Lamotrigine and its pharmaceutically acceptable salts and process of preparing such compositions. The liquid and powder for oral suspension dosage forms of Lamotrigine have been previously known only as extemporaneous preparations. Present invention relates to manufacture of liquid and powder for oral suspension dosage forms of Lamotrigine having improved physico-chemical properties with desired technical attributes. The prepared dosage forms are useful in patients having difficulties in swallowing tablets and provide physician with more options for dose titration.

Abstract: The present invention discloses stable delayed release multiparticulate powder for oral suspension of proton pump inhibitor compounds comprising: a) a core with an effective amount of proton pump inhibitor and at least one or more pharmaceutical excipients, b) at least one water-soluble seal coating over core c) at least one enteric coating layer over the seal coat wherein the said core comprises disintegrant (0-10%) and/or surfactant (0-2%) w/w of core. The prior art discloses restrictive formulation technique and suggest high amount of various excipients to achieve desired technical attributes. The prepared test formulations exhibited desired pharmaceutical technical attributes like drug release, assay, stability, no polymorphic change, reduced sticking to nasogastric and gastronomy tubes, and packaging material.

Abstract: The present application relates to pharmaceutical compositions comprising retinoic acid or its derivatives such as isotretinoin and processes for preparing thereof. It also provides methods for treating acne by administering such pharmaceutical composition to a patient in need thereof.

Abstract: System and methods for personalizing an application include an application server for hosting an application that is executed on a wireless device, the server being configured to monitor usage of a user interface including an interaction between a user of the application and one or more user interface elements and present an updated user interface comprising one or more additional user-interface elements based on the usage.

Abstract: The present invention relates to a solid oral pharmaceutical dosage form suitable for making a suspension comprising acid labile benzimidazole compounds and process for preparing the same. The prior art discloses various technical challenges associated with the granules for reconstitution into suspension like agglomeration of particles, viscosity and gelling time. The solid oral pharmaceutical dosage form of the present invention forms a homogeneous suspension upon admixing with an aqueous medium and exhibits desired technical attributes like viscosity, drug release, gelling time, dissolution and reduced adherence to nasogastric and gastric tubes.

Abstract: The present invention relates to immediate release pharmaceutical compositions comprising Brivaracetam or its pharmaceutically acceptable salts, esters, solvates, derivatives, amides, polymorphs, enantiomers, prodrugs, analogues, active metabolites or mixtures thereof. The present invention also relates to a process for preparing solid oral pharmaceutical composition comprising Brivaracetam. The prior art highlights various technical challenges for the formulation development of Brivaracetam and offers restrictive and complex approach for resolution of technical challenges like use of cyclodextrin. Cyclodextrin free compositions of Brivaracetam prepared as per present invention, exhibited desirable technical attributes.

Abstract: The present invention discloses stable delayed release multiparticulate powder for oral suspension of proton pump inhibitor compounds comprising: a) a core with an effective amount of proton pump inhibitor and at least one or more pharmaceutical excipients, b) at least one water-soluble seal coating over core c) at least one enteric coating layer over the seal coat wherein the said core comprises disintegrant (0-10%) and/or surfactant (0-2%) w/w of core. The prior art discloses restrictive formulation technique and suggest high amount of various excipients to achieve desired technical attributes. The prepared test formulations exhibited desired pharmaceutical technical attributes like drug release, assay, stability, no polymorphic change, reduced sticking to nasogastric and gastronomy tubes, and packaging material.

Abstract: Methods and arrangements for filtering audio in a noisy environment involving receiving audio input at a user's location, using a plurality of audio input devices in proximity with a user. The audio is then separated into sources in response to a user selection. After the selection is made, the amplitudes of the audio sources are adjusted based on the selection. Other variants and embodiments are broadly contemplated herein.

Abstract: The disclosed embodiments illustrate methods and systems to recommend medical intervention activities for caregivers and/or human subjects. The method comprises receipt of medical data of a human subject and contextual data of a plurality of caregivers of the human subjects. The medical data includes periodic physiological data of the human subject received in real-time. A customized ontology is generated, from a pre-determined ontology related to a medical condition, based on the received medical data and the contextual data. Thereafter, a recommendation of medical intervention activities is generated for at least one of the plurality of caregivers and/or the human subject, based on analysis of the generated customized ontology, caregiver profiles, the received contextual data, and the periodic physiological data. The generated recommendation is transmitted to computing devices of the at least one caregiver and/or the human subject.

Abstract: The present application relates to pharmaceutical compositions comprising retinoic acid or its derivatives such as isotretinoin and processes for preparing thereof. It also provides methods for treating acne by administering such pharmaceutical composition to a patient in need thereof.

Abstract: The present disclosure provides methods for biosynthesis of acetaminophen. The present disclosure provides host cells genetically modified to provide for production of acetaminophen. The present disclosure provides a recombinant host cell that is genetically modified with one or more heterologous nucleic acids comprising nucleotide sequences encoding 4-aminobenzoate hydroxylase (4ABH) and N-hydroxyarylamine O-acetyltransferase (NhoA). The present disclosure provides a recombinant prokaryotic host cell that is genetically modified with one or more heterologous nucleic acids comprising nucleotide sequences encoding 44ABH and NhoA.

Abstract: The present disclosure provides compositions and methods for the biosynthetic production of carnosine and beta-alanine.

Abstract: The present disclosure provides compositions and methods for the biosynthetic production of choline, ethanolamine, phosphoethanolamine, and phosphocholine.

Abstract: The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.

Abstract: Methods and arrangements for filtering audio in a noisy environment involving receiving audio input at a user's location, using a plurality of audio input devices in proximity with a user. The audio is then separated into sources in response to a user selection. After the selection is made, the amplitudes of the audio sources are adjusted based on the selection. Other variants and embodiments are broadly contemplated herein.

Abstract: According to some embodiments, a method and system provides receiving a list of a plurality of conversations, each of the conversations associated with a common set of characteristics and each of the conversations having associated conversation details; presenting at least a portion of the list of the plurality of conversations in a user interface, each of the conversations included in the presented portion of the list being separately represented; receiving a selection of a plurality of the conversations included in the presented portion of the list; and presenting, simultaneously and grouped together in the user interface, conversation details associated with each of the selected plurality of the conversations, separate and apart from the presented portion of the list.

Abstract: Methods and arrangements for effecting authentication in a secure transaction. There are defined, on behalf of a user, individuals who are members of a social network of the user. There is received, from the user, a transaction request for a secure transaction. An authentication test is conducted with the user and, upon meeting a predetermined requirement of the authentication test, the transaction request is validated. The authentication test requests the user to confirm at least one information item related to at least one member of the user's social network. Other variants and embodiments are broadly contemplated herein.

Abstract: The present invention relates to a system and method for network performance management for monitoring performance of network applications. The system comprises a transmitter for sending one or more types of probe packets to the network, a receiver for receiving the one or more network probe packets from the network and for receiving one or more network application performance queries from one or more network applications, a processor connected to the transmitter and the receiver and operable to process network probe packets received by the receiver to generate network performance statistics for each type of probe packet and to look up the network application performance requirements of the one or more network applications and compare the network application performance requirements with the corresponding network performance statistics to determine whether the network application should access the network.

Abstract: The present invention relates to extended release dosage forms of metoprolol or salts thereof comprising a water insoluble and non-swellable inert core and one or more pharmaceutically acceptable excipients. The invention also relates to processes for the preparation of an inert core and extended release dosage forms.