Abstract: Antimicrobial modified defensin or defensin-like peptides, modified C-terminal fragments of a defensin or defensin-like peptides and nucleic acids encoding the same are disclosed. Compositions comprising the defensin variant peptides and methods of their use to control microbial infections of plants and vertebrate subjects as well as contamination of feedstuffs and foodstuffs are also disclosed.

Abstract: Methods of producing recombinant, multi-component proteins in eukaryotic expression systems, comprising co-transforming a eukaryotic cell with two or more different nucleic acid constructs, each comprising a respective transcriptional unit encoding a protein component, wherein each nucleic acid construct comprises the same promoter and signal sequence, such that each of the components will be targeted to the same organelle of the cell for expression and intracellular assembly. In one or more embodiments, each nucleic acid construct comprises a promoter from a protein storage gene that is operably linked to a DNA sequence that encodes for a protein storage-specific signal sequence.

Abstract: Stabilized formulations for Immunoglobulin A and other biotherapeutic proteins. Formulations comprising at least one pH buffering agent at about pH 5 to about 8, optional non-ionic surfactant, and one or more optional stabilizing agents selected from the group consisting of amino acids, sugars/polyols, chloride salts, carboxylic acids, detergents, natural proteins, protein expression extracts, and mixtures thereof.