Patents by Inventor Savas Tasoglu

Savas Tasoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240361343
    Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
    Type: Application
    Filed: July 12, 2024
    Publication date: October 31, 2024
    Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
  • Patent number: 12066445
    Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: August 20, 2024
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
  • Publication number: 20220073872
    Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.
    Type: Application
    Filed: August 20, 2021
    Publication date: March 10, 2022
    Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu, Paolo Nicolas Catalano
  • Publication number: 20210373037
    Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
    Type: Application
    Filed: February 8, 2021
    Publication date: December 2, 2021
    Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
  • Patent number: 10928404
    Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: February 23, 2021
    Assignees: The Brigham and Women's Hospital, Inc., The Board of Trustees of the Leland Stanford Junior University, Beth Israel Deaconess Medical Center
    Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
  • Publication number: 20200368745
    Abstract: A fluid analysis device can include a fluid inlet opening configured to receive a test fluid, and one or more fluid distribution channels in fluid communication with the fluid inlet opening and configured to receive and distribute the test fluid from the fluid inlet opening using a passive self-loading mechanism. The device can include a plurality of assays fluidly isolated from each other and configured to receive the test fluid from the one or more fluid distribution channels.
    Type: Application
    Filed: May 22, 2020
    Publication date: November 26, 2020
    Applicant: University of Connecticut
    Inventors: Savas Tasoglu, Reza Amin, Stephanie Knowlton
  • Publication number: 20190316084
    Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 17, 2019
    Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu, Paolo Nicolas Catalano
  • Patent number: 10208282
    Abstract: In one aspect, the present disclosure provides a method for self-assembly of magnetic building blocks, including distributing a plurality of building blocks in a liquid medium, each of the plurality of building blocks having a plurality of stable radicals, establishing a magnetic field interacting with at least a portion of the plurality of building blocks, guiding with the magnetic field the portion of the plurality of building blocks from a first location in the liquid medium to a second location in the liquid medium, assembling into a first construct the portion of the plurality of building blocks proximate the second location, and treating the first construct with at least one antioxidant to neutralize at least in part the plurality of stable radicals.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: February 19, 2019
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Utkan Demirci, Savas Tasoglu
  • Publication number: 20160370386
    Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
    Type: Application
    Filed: February 26, 2015
    Publication date: December 22, 2016
    Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
  • Publication number: 20160362655
    Abstract: In one aspect, the present disclosure provides a method for self-assembly of magnetic building blocks, including distributing a plurality of building blocks in a liquid medium, each of the plurality of building blocks having a plurality of stable radicals, establishing a magnetic field interacting with at least a portion of the plurality of building blocks, guiding with the magnetic field the portion of the plurality of building blocks from a first location in the liquid medium to a second location in the liquid medium, assembling into a first construct the portion of the plurality of building blocks proximate the second location, and treating the first construct with at least one antioxidant to neutralize at least in part the plurality of stable radicals.
    Type: Application
    Filed: February 25, 2015
    Publication date: December 15, 2016
    Inventors: Utkan Demirci, Savas Tasoglu
  • Publication number: 20140248656
    Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.
    Type: Application
    Filed: May 18, 2012
    Publication date: September 4, 2014
    Applicant: THE BRIGHAM AND WOMEN S HOSPITAL, INC.
    Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu