Patents by Inventor Savas Tasoglu
Savas Tasoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240361343Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: ApplicationFiled: July 12, 2024Publication date: October 31, 2024Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Patent number: 12066445Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: GrantFiled: February 8, 2021Date of Patent: August 20, 2024Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTERInventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Publication number: 20220073872Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.Type: ApplicationFiled: August 20, 2021Publication date: March 10, 2022Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu, Paolo Nicolas Catalano
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Publication number: 20210373037Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: ApplicationFiled: February 8, 2021Publication date: December 2, 2021Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Patent number: 10928404Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: GrantFiled: February 26, 2015Date of Patent: February 23, 2021Assignees: The Brigham and Women's Hospital, Inc., The Board of Trustees of the Leland Stanford Junior University, Beth Israel Deaconess Medical CenterInventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Publication number: 20200368745Abstract: A fluid analysis device can include a fluid inlet opening configured to receive a test fluid, and one or more fluid distribution channels in fluid communication with the fluid inlet opening and configured to receive and distribute the test fluid from the fluid inlet opening using a passive self-loading mechanism. The device can include a plurality of assays fluidly isolated from each other and configured to receive the test fluid from the one or more fluid distribution channels.Type: ApplicationFiled: May 22, 2020Publication date: November 26, 2020Applicant: University of ConnecticutInventors: Savas Tasoglu, Reza Amin, Stephanie Knowlton
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Publication number: 20190316084Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.Type: ApplicationFiled: April 23, 2019Publication date: October 17, 2019Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu, Paolo Nicolas Catalano
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Patent number: 10208282Abstract: In one aspect, the present disclosure provides a method for self-assembly of magnetic building blocks, including distributing a plurality of building blocks in a liquid medium, each of the plurality of building blocks having a plurality of stable radicals, establishing a magnetic field interacting with at least a portion of the plurality of building blocks, guiding with the magnetic field the portion of the plurality of building blocks from a first location in the liquid medium to a second location in the liquid medium, assembling into a first construct the portion of the plurality of building blocks proximate the second location, and treating the first construct with at least one antioxidant to neutralize at least in part the plurality of stable radicals.Type: GrantFiled: February 25, 2015Date of Patent: February 19, 2019Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Savas Tasoglu
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Publication number: 20160370386Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: ApplicationFiled: February 26, 2015Publication date: December 22, 2016Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Publication number: 20160362655Abstract: In one aspect, the present disclosure provides a method for self-assembly of magnetic building blocks, including distributing a plurality of building blocks in a liquid medium, each of the plurality of building blocks having a plurality of stable radicals, establishing a magnetic field interacting with at least a portion of the plurality of building blocks, guiding with the magnetic field the portion of the plurality of building blocks from a first location in the liquid medium to a second location in the liquid medium, assembling into a first construct the portion of the plurality of building blocks proximate the second location, and treating the first construct with at least one antioxidant to neutralize at least in part the plurality of stable radicals.Type: ApplicationFiled: February 25, 2015Publication date: December 15, 2016Inventors: Utkan Demirci, Savas Tasoglu
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Publication number: 20140248656Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.Type: ApplicationFiled: May 18, 2012Publication date: September 4, 2014Applicant: THE BRIGHAM AND WOMEN S HOSPITAL, INC.Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu