Patents by Inventor Savina Malancona

Savina Malancona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for use in the treatment of kinetoplastid infection
    Patent number: 10815222
    Abstract: The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions containing the compounds and their use in the treatment of kinetoplastid infections.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 27, 2020
    Assignee: C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING
    Inventors: Ilaria Biancofiore, Alina Ciammaichella, Federica Ferrigno, Steven Harper, Savina Malancona, Jesus Maria Ontoria Ontoria, Giacomo Paonessa, Simona Ponzi, Vincenzo Summa
  • COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION
    Publication number: 20200095232
    Abstract: The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions containing the compounds and their use in the treatment of kinetoplastid infections.
    Type: Application
    Filed: December 21, 2017
    Publication date: March 26, 2020
    Applicant: C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING
    Inventors: Ilaria BIANCOFIORE, Alina CIAMMAICHELLA, Federica FERRIGNO, Steven HARPER, Savina MALANCONA, Jesus Maria ONTORIA ONTORIA, Giacomo PAONESSA, Simona PONZI, Vincenzo SUMMA
  • PANTETHEINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGIC DISORDERS
    Publication number: 20190337971
    Abstract: Compounds having the following formula (I): Formula I and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.
    Type: Application
    Filed: July 24, 2017
    Publication date: November 7, 2019
    Inventors: Maria Beconi, Daniel Elbaum, Savina Malancona
  • Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
    Patent number: 10364263
    Abstract: Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: July 30, 2019
    Assignee: Retrophin, Inc.
    Inventors: Maria Beconi, Daniel Elbaum, Steven Harper, Savina Malancona
  • CYCLIC PHOSPHATES AND CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF NEUROLOGIC DISORDERS
    Publication number: 20180362564
    Abstract: Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 20, 2018
    Inventors: Maria Beconi, Daniel Elbaum, Steven Harper, Savina Malancona
  • Compounds for use in the treatment of parasitic diseases
    Patent number: 9365541
    Abstract: The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: June 14, 2016
    Assignee: IRBM—SCIENCE PARK S.P.A.
    Inventors: Sergio Altamura, Ilaria Biancofiore, Alberto Bresciani, Federica Ferrigno, Steven Harper, Ralph Laufer, Jesus Maria Ontoria Ontoria, Savina Malancona, Edith Monteagudo, Emanuela Nizi, Maria Vittoria Orsale, Simona Ponzi, Giacomo Paonessa, Vincenzo Summa, Maria Veneziano
  • COMPOUNDS FOR USE IN THE TREATMENT OF PARASITIC DISEASES
    Publication number: 20150299163
    Abstract: The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.
    Type: Application
    Filed: October 30, 2013
    Publication date: October 22, 2015
    Applicants: IRBM - SCIENCE PARK S.P.A., C.N.C.C.S. SCARL COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING
    Inventors: Sergio ALTAMURA, Ilaria BIANCOFIORE, Alberto BRESCIANI, Federica FERRIGNO, Steven HARPER, Ralph LAUFER, Jesus Maria ONTORIA ONTORIA, Savina MALANCONA, Edith MONTEAGUDO, Emanuela NIZI, Maria Vittoria ORSALE, Simona PONZI, Giacomo PAONESSA, Vincenzo SUMMA, Maria VENEZIANO
  • Saturated bicyclic heterocyclic derivatives as SMO antagonists
    Patent number: 8470823
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: June 25, 2013
    Assignee: Instituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
    Inventors: Danila Branca, Federica Ferrigno, Jose Ignacio Martin Hernando, Philip Jones, Olaf Kinzel, Savina Malancona, Ester Muraglia, Maria Cecilia Palumbi, Giovanna Pescatore, Rita Scarpelli
  • SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS
    Publication number: 20110183989
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
    Type: Application
    Filed: August 28, 2009
    Publication date: July 28, 2011
    Inventors: Danila Branca, Federica Ferrigno, Jose Ignacio Martin Hernando, Philip Jones, Olaf Kinzel, Savina Malancona, Ester Muraglia, Maria Cecilia Palumbi, Giovanna Pescatore, Rita Scarpelli
  • Thienopyrroles as antiviral agents
    Patent number: 7781431
    Abstract: The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: August 24, 2010
    Assignee: Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
    Inventors: Barbara Attenni, Jose Ignacio Martin Hernando, Savina Malancona, Frank Narjes, Jesus Maria Ontoria Ontoria, Michael Rowley
  • Thienopyrroles as antiviral agents
    Publication number: 20090036443
    Abstract: The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
    Type: Application
    Filed: September 7, 2004
    Publication date: February 5, 2009
    Inventors: Barbara Attenni, Jose Ignacio Martin Hernando, Savina Malancona, Frank Narjes, Jesus Maria Ontoria Ontaria, Michael Rowley
  • Imidazole and Thioazole Derivatives as Antiviral Agents
    Publication number: 20080249146
    Abstract: The present invention relates to compounds of the formula (I), wherein R1, R2, A, B, D, E, F, G and Ar are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
    Type: Application
    Filed: July 14, 2005
    Publication date: October 9, 2008
    Inventors: Immacolata Conte, Jose Ignacio Martin Hernando, Savina Malancona, Jesus Maria Ontoria Ontoria, Ian Stansfield
  • Pyrimidinone viral polymerase inhibitors
    Publication number: 20050130997
    Abstract: A class of pyrimidinone derivatives of formula (I): wherein Z, R1, R2 and R3 are as defined herein; and pharmaceutically acceptable salts thereof; are inhibitors of viral polymerases, especially (the hepatitis C virus (HCV) polymerase enzyme.
    Type: Application
    Filed: January 15, 2003
    Publication date: June 16, 2005
    Inventors: Salvatore Avolio, Stefania Colarusso, Immacolata Conte, Steven Harper, Uwe Koch, Savina Malancona, Vincenzo Summa, Frank Narjes, Alessia Petrocchi