Abstract: This invention is directed to pharmaceutical compositions comprising tocotrienol and the use of such compositions to treat non-alcoholic steatohepatitis.

Abstract: Compositions and methods are provided for preparing an article that comprises an electroceutical material that comprises a redox pair of alternating metals that generate an electric current or field when exposed to an aqueous solution. In one embodiment filtering equipment including facial masks are prepared comprising the electroceutical materials.

Abstract: Compositions and methods are provided for reprogramming demal fibroblasts to exhibit neurogenic properties including increased cell expression of NGF and Nt3 in vivo. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use in treating neuropathic pain and stabilizing or stimulating production of PGP9.5+ mature nerve fiber in a diabetic patient’s tissues.

Abstract: The present disclosure relates to topical tocotrienol compositions, dosing regimens, and methods for increasing the stem cell content of the skin. The present invention further relates to topical tocotrienol compositions, dosing regimens, and methods for the treatment of skin disorders.

Abstract: The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the present methods. The present invention also provides methods to increase skin tissue concentrations of tocotrienols.

Abstract: The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.

Abstract: Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.

Abstract: The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.

Abstract: The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the present methods. The present invention also provides methods to increase skin tissue concentrations of tocotrienols.

Abstract: Methods for reducing blood clotting in a subject are provided, including methods to reduce the risk of and/or treat blot clotting pathologies. Also provided are compositions useful to reduce the risk or treat blood clotting pathologies.

Abstract: The present invention provides methods to improve liver function utilizing tocotrienols. In particular, various liver pathologies may be treated using the present methods, including cirrhosis, hepatitis, and sclerosing cholangtitis. The present invention also provides methods to increase tissue concentrations of tocotrienols.

Abstract: An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).

Abstract: The invention provides methods, delivery devices, and compositions for topically oxygenating hypoxic tissue with a hemoglobin-based oxygen earner (HBOC), such as Oxyglobin (Oxyb) in order to promote wound healing and/or reducing hypoxia in post-harvest transplant tissue. The invention can be used, among other things, to stimulate angiogenesis and blood flow at a wound site, reduce wound dilation, and promote wound contraction, thereby increasing the overall rate of wound healing. The invention can also be used, among other things, to reduce oxidative stress in pre-implantation donor organ tissue, as well as stimulate the proliferation of granulation tissue, vessel growth, and promote epithelial healing in transplant tissue once it has been implanted.

Abstract: An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).

Abstract: Therapeutic and prophylactic agents comprising tocotrienols, and methods of using the same are provided for the treatment of and the prevention of the onset of stroke and other disorders and diseases associated with elevated glutamate levels, and the effects of lipoxygenases such as the enzyme 12-lipoxygenase.