Patents by Inventor Savvas Makrides

Savvas Makrides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
    Patent number: 5256642
    Abstract: The present invention relates to compositions comprising soluble complement receptor 1 (CR1) and a thrombolytic agent. In a specific embodiment, the thrombolytic agent is anisoylated human plasminogen-streptokinase activator complex (ASPAC). The invention further relates to methods for treating thrombotic conditions in humans and animals by administering a composition comprising soluble CR1 and a thrombolytic agent. In particular, the compositions and methods are useful both for reducing reperfusion injury and ameliorating the other effects of myocardial infarction.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: October 26, 1993
    Assignees: The Johns Hopkins University, Brigham and Women's Hospital, T Cell Sciences, Inc.
    Inventors: Douglas T. Fearon, Lloyd B. Klickstein, Winnie W. Wong, Gerald R. Carson, Michael F. Concino, Stephen H. Ip, Savvas Makrides, Henry C. Marsh, Jr.