Patents by Inventor Sayan Mondal

Sayan Mondal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20230365584
    Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
    Type: Application
    Filed: September 8, 2021
    Publication date: November 16, 2023
    Inventors: Xianhai HUANG, Sayan MONDAL, Phani GHANAKOTA, Nicholas BOYLES, Leah FRYE, Adam LEVINSON, Jeremy Robert GREENWOOD, Pieter BOS, Sathesh BHAT, Aleksey GERASYUTO, Haifeng TANG
  • METHODS FOR PREDICTING AN ACTIVE SET OF COMPOUNDS HAVING ALTERNATIVE CORES, AND DRUG DISCOVERY METHODS INVOLVING THE SAME
    Publication number: 20230317214
    Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.
    Type: Application
    Filed: June 6, 2023
    Publication date: October 5, 2023
    Inventors: Robert L. Abel, Lingle Wang, Sathesh Bhat, Sayan Mondal, Jeremy Robert Greenwood, Kyle Konze
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20230265075
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: April 26, 2023
    Publication date: August 24, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • Methods for predicting an active set of compounds having alternative cores, and drug discovery methods involving the same
    Patent number: 11710543
    Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 25, 2023
    Assignee: Schrödinger, Inc.
    Inventors: Robert L. Abel, Lingle Wang, Sathesh Bhat, Sayan Mondal, Jeremy Robert Greenwood, Kyle Konze
  • 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Patent number: 11691963
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: July 4, 2023
    Assignee: Ajax Therapeutics, Inc.
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20230167110
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: November 8, 2022
    Publication date: June 1, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • FORMS AND COMPOSITIONS OF INHIBITORS OF JAK2
    Publication number: 20230146125
    Abstract: The present disclosure provides compounds and compositions thereof which are useful as inhibitors of JAK2 and which exhibit desirable characteristics for the same.
    Type: Application
    Filed: November 8, 2022
    Publication date: May 11, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
  • SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS TYK2 INHIBITORS
    Publication number: 20230110996
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: June 14, 2022
    Publication date: April 13, 2023
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20230099203
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: December 22, 2021
    Publication date: March 30, 2023
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • CYCLIC COMPOUNDS AND METHODS OF USING SAME
    Publication number: 20230101747
    Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 30, 2023
    Inventors: Xianhai Huang, Sayan Mondal, Phani Ghanakota, Nicholas Boyles, Leah Frye, Aleksey Gerasyuto, Jeremy Robert Greenwood, Haifeng Tang, Adam Marc Levinson
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230074228
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: July 20, 2022
    Publication date: March 9, 2023
    Inventors: Craig E. MASSE, Jeremy Robert GREENWOOD, Donna L. ROMERO, Geraldine C. HARRIMAN, Ronald T. WESTER, Mee SHELLEY, Joshua Jahmil KENNEDY-SMITH, Markus DAHLGREN, Sayan MONDAL, Shaughnessy ROBINSON
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230056447
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: September 14, 2021
    Publication date: February 23, 2023
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. Mclean
  • 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
    Publication number: 20220411403
    Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
    Type: Application
    Filed: May 5, 2021
    Publication date: December 29, 2022
    Inventors: Craig E. Masse, Jeremy R. Greenwood, Sayan Mondal, Jiayi Xu, Phani Ghanakota, Fiona Michelle McRobb, Nicholas Boyles
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20220356184
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: March 23, 2021
    Publication date: November 10, 2022
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal, Scott D. Cowen, Thomas H. McLean
  • TYK2 inhibitors and uses thereof
    Patent number: 11434240
    Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: September 6, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Donna L. Romero, Geraldine C. Harriman, Ronald T. Wester, Mee Shelley, Joshua Jahmil Kennedy-Smith, Markus Dahlgren, Sayan Mondal, Shaughnessy Robinson
  • Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
    Patent number: 11414431
    Abstract: The present invention provides compounds of Formula I?: compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: August 16, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Sayan Mondal
  • TYK2 inhibitors and uses thereof
    Patent number: 11396508
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 26, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Silvana Marcel Leit de Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20220073527
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Application
    Filed: September 17, 2021
    Publication date: March 10, 2022
    Inventors: Jeremy Robert GREENWOOD, Geraldine C. HARRIMAN, Silvana M. LEIT DE MORADEI, Craig E. MASSE, Thomas H. MCLEAN, Sayan MONDAL
  • TYK2 inhibitors and uses thereof
    Patent number: 11220508
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: January 11, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit De Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal
  • TYK2 inhibitors and uses thereof
    Patent number: 11174265
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: November 16, 2021
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Silvana Marcel Leit De Moradei, Craig E. Masse, Thomas H. McLean, Sayan Mondal