Patents by Inventor Sayda Elbashir

Sayda Elbashir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules
    Publication number: 20150337311
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides.
    Type: Application
    Filed: February 17, 2015
    Publication date: November 26, 2015
    Inventors: Rachel Meyers, Rene Alvarez, Geoff Cole, Sayda Elbashir
  • RNAi modulation of ApoB and uses thereof
    Patent number: 9187747
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: November 17, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • Methods and compositions for prevention or treatment of RSV infection
    Patent number: 9127277
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: September 8, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Akshay Vaishnaw, Saraswathy V. Nochur, Sayda Elbashir, Muthiah Manoharan, Rachel Meyers
  • Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules
    Publication number: 20140323541
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides.
    Type: Application
    Filed: September 5, 2012
    Publication date: October 30, 2014
    Inventors: Rachel Meyers, Rene Alvarez, Geoff Cole, Sayda Elbashir
  • RNAi Modulation Of ApoB And Uses Thereof
    Publication number: 20140045922
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 13, 2014
    Applicant: Alnylam Pharmaceuticals, Inc.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • RNAi modulation of APOB and uses thereof
    Patent number: 8592571
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: November 26, 2013
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • Methods And Compositions For Prevention Or Treatment Of RSV Infection
    Publication number: 20130165499
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets.
    Type: Application
    Filed: February 27, 2013
    Publication date: June 27, 2013
    Inventors: Akshay Vaishnaw, Saraswathy V. Nochur, Sayda Elbashir, Muthiah Manoharan, Rachel Meyers
  • LIPID FORMULATED SINGLE STRANDED RNA
    Publication number: 20130156845
    Abstract: The present invention provides compositions comprising a nucleic acid lipid particle and an oligomeric compound and uses thereof. In certain embodiments, such compositions are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.
    Type: Application
    Filed: April 29, 2011
    Publication date: June 20, 2013
    Applicants: ALNYLAM PHARMACEUTICALS, INC., ISIS PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Sayda Elbashir, Kallanthottathil G. Rajeev, Thazha P. Prakash, Walter F. Lima, Eric E. Swayze
  • Methods and compositions for prevention or treatment of RSV infection
    Patent number: 8410073
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA comprises a sense strand of ALN-RSV01 and an antisense strand of ALN-RSV01.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 2, 2013
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Akshay Vaishnaw, Saraswathy V. Nochur, Sayda Elbashir, Muthiah Manoharan, Rachel Meyers
  • RNAi Modulation of APOB and Uses Thereof
    Publication number: 20120252872
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Application
    Filed: April 19, 2012
    Publication date: October 4, 2012
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • METHODS AND COMPOSITIONS FOR PREVENTION OR TREATMENT OF RSV INFECTION
    Publication number: 20120189555
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA comprises a sense strand of ALN-RSV01 and an antisense strand of ALN-RSV01.
    Type: Application
    Filed: January 26, 2012
    Publication date: July 26, 2012
    Inventors: Akshay Vaishnaw, Saraswathy V. Nochur, Sayda Elbashir, Muthiah Manoharan, Rachel Meyers
  • RNAi modulation of APOB and uses thereof
    Patent number: 8188061
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: May 29, 2012
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • MODULATION OF LDL RECEPTOR GENE EXPRESSION WITH DOUBLE-STRANDED RNAS TARGETING THE LDL RECEPTOR GENE PROMOTER
    Publication number: 20110110860
    Abstract: Gene expression can be selectively regulated by double-stranded “antigene” RNAs that target regions of the low density lipoprotein receptor (LDL-R) promoter, thereby permitting modulation of LDL levels in vivo and subsequent effects on circulating LDL levels.
    Type: Application
    Filed: November 2, 2010
    Publication date: May 12, 2011
    Applicants: The Board of Regents of the University of Texas System, Alnylam Pharmaceuticals Inc.
    Inventors: DAVID R. COREY, Masayuki Matsui, Muthiah Manoharan, Sayda Elbashir
  • RNAi Modulation of APOB and Uses Thereof
    Publication number: 20100216866
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Application
    Filed: March 19, 2010
    Publication date: August 26, 2010
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • Methods and Compositions for Prevention or Treatment of RSV Infection Using Modified Duplex RNA Molecules
    Publication number: 20100168205
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides.
    Type: Application
    Filed: October 23, 2009
    Publication date: July 1, 2010
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Rachel Meyers, Rene Alvarez, Geoff Cole, Sayda Elbashir
  • RNAi modulation of ApoB and uses thereof
    Patent number: 7723317
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: May 25, 2010
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • RNAi Modulation Of ApoB And Uses Thereof
    Publication number: 20090312397
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Application
    Filed: March 9, 2009
    Publication date: December 17, 2009
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • METHODS AND COMPOSITIONS FOR PREVENTION OR TREATMENT OF RSV INFECTION
    Publication number: 20090238772
    Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA comprises a sense strand of ALN-RSV01 and an antisense strand of ALN-RSV01.
    Type: Application
    Filed: December 15, 2008
    Publication date: September 24, 2009
    Applicant: Alnylam Pharmaceuticals, Inc.
    Inventors: Akshay Vaishnaw, Saraswathy V. Nochur, Sayda Elbashir, Muthiah Manoharan, Rachel Meyers
  • RNAi modulation of ApoB and uses thereof
    Patent number: 7528118
    Abstract: The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: May 5, 2009
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Juergen Soutschek, Hans-Peter Vornlocher, Philipp Hadwiger, Sayda Elbashir
  • RNA interference mediating small RNA molecules
    Publication number: 20070093445
    Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
    Type: Application
    Filed: December 6, 2006
    Publication date: April 26, 2007
    Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e. V.
    Inventors: Thomas Tuschl, Sayda Elbashir, Winfried Lendeckel