Patents by Inventor Scot R. Shepard

Scot R. Shepard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230227790
    Abstract: Disclosed are methods of a method of making a nanostructure, comprising adding a component A (compA) protein to a solution comprising a component B (compB) protein under conditions that minimize shear stress, thereby forming a compA:compB complex. Further disclosed are methods of making a nanostructure, comprising (i) providing a first inlet fluid stream comprising a first protein and a second inlet fluid stream comprising a second protein, and (ii) contacting the first inlet fluid stream and the second inlet fluid stream to form an outlet stream, wherein mixing of the first protein and the second protein occurs in the outlet stream, thereby forming a protein complex comprises the first protein and the second protein. A microfluidic mixer may be used. The methods may further comprise purifying the compA:compB complex from excess compA, excess compB, and/or other impurities by filtering the solution with a 1,000 kDa membrane or an equivalent thereof.
    Type: Application
    Filed: June 9, 2021
    Publication date: July 20, 2023
    Inventors: Scot R. SHEPARD, Hans R. LIEN, Ross M. TAYLOR, Charles RICHARDSON
  • Patent number: 7476726
    Abstract: The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of recombinantly-produced endostatin protein.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: January 13, 2009
    Assignees: The Children's Medical Center Corp., Covance Biotechnology Services, Inc.
    Inventors: Hong Liang, Kim Lee Sim, Amy Chang-Murad, Xinhua Zhou, John Madsen, Renee J. Boerner, Firoz Rustom Mistry, Scot R. Shepard, Jeffrey L. Schrimsher, Lourdes L. Bermejo
  • Patent number: 7229789
    Abstract: A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective amount of a detergent.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: June 12, 2007
    Assignee: N.V. Organon
    Inventor: Scot R. Shepard
  • Patent number: 6723536
    Abstract: The present invention provides a method for recombinant production, recovery and purification of angiostatin protein. This method may be employed for large scale recovery and purification of recombinantly-produced angiostatin protein.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: April 20, 2004
    Assignee: EntreMed, Inc.
    Inventors: John Madsen, Hong Liang, Kim Lee Sim, Xinhua Zhou, Amy Chang-Murad, Renee J. Boerner, Lourdes L. Bermejo, Firoz R. Mistry, Jeffrey L. Schrimsher, Scot R. Shepard, Jeremy Johnston
  • Publication number: 20040047844
    Abstract: The present invention relates to methods and processes of inactivating viral contaminants in a biological source material (e.g. a host cell, cell supernatant, cell lysate, blood plasma, tissue homogenate, or other biological materials) with a solution containing one or more alkylamine compounds. In a particular embodiment, the active ingredients are amphipathic, charged amines or amine oxides coupled to saturated hydrocarbon chains of varying lengths.
    Type: Application
    Filed: June 24, 2003
    Publication date: March 11, 2004
    Inventor: Scot R. Shepard
  • Patent number: 6635679
    Abstract: The present invention relates to methods and processes of inactivating a viral contaminants in a biological source material or process intermediate by contacting the biological source material (e.g., a host cell, cell supernatant, cell lysate, blood plasma, tissue homogenate, or other biological materials) with a solution containing one or more alkylamine compounds. In a particular embodiment, the active ingredients are amphipathic, charged amines or amine oxides coupled to saturated hydrocarbon chains of varying lengths.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: October 21, 2003
    Assignee: Akzo Nobel N.V.
    Inventor: Scot R. Shepard
  • Publication number: 20030104525
    Abstract: The present invention provides a method for recombinant production, recovery and purification of angiostatin protein. This method may be employed for large scale recovery and purification of recombinantly-produced angiostatin protein.
    Type: Application
    Filed: October 18, 2001
    Publication date: June 5, 2003
    Inventors: John Madsen, Hong Liang, Kim Lee Sim, Xinhua Zhou, Amy Chang-Murad, Renee J. Boerner, Lourdes L. Bermejo, Firoz R. Mistry, Jeffrey L. Schrimsher, Scot R. Shepard, Jeremy Johnston
  • Publication number: 20020169214
    Abstract: The present invention relates to methods and processes of inactivating a viral contaminants in a biological source material or process intermediate by contacting the biological source material (e.g., a host cell, cell supernatant, cell lysate, blood plasma, tissue homogenate, or other biological materials) with a solution containing one or more alkylamine compounds. In a particular embodiment, the active ingredients are amphipathic, charged amines or amine oxides coupled to saturated hydrocarbon chains of varying lengths.
    Type: Application
    Filed: May 14, 2001
    Publication date: November 14, 2002
    Inventor: Scot R. Shepard