Abstract: A therapeutic agent delivery device includes a disposable portion and a reusable portion that detachably carries the disposable portion. The reusable portion includes a drive mechanism having a guide, a rotary actuator, and a follower drivably coupled to the rotary actuator and movably coupled to the guide. The rotary actuator is actuatable to rotatably drive the follower, and the follower thereby follows the guide and translates the drive mechanism. The drive mechanism thereby translates a syringe assembly of the disposable portion from a stowed configuration to a deployed configuration.

Abstract: The technology disclosed relates to a method of realistic simulation of real world interactions as virtual interactions between a control object sensed acting in a three-dimensional (3D) sensory space and the virtual object in a virtual space that the control object interacts with. In particular, it relates to detecting free-form gestures of a control object in a three-dimensional (3D) sensory space and generating for display a 3D solid control object model for the control object during the free-form gestures, including sub-components of the control object and in response to detecting a free-form gesture of the control object in the 3D sensory space in virtual contact with the virtual object, depicting, in the generated display, the virtual contact and resulting motions of the virtual object by the 3D solid control object model.

Abstract: A sports electronic training system, and applications thereof, are disclosed. In an embodiment, a portable performance monitoring system for monitoring an individual's performance during a physical activity includes a motion monitor adapted to be physically coupled to the individual during the activity and a portable electronic processing device adapted to be physically coupled to the individual during the activity. The portable electronic processing device includes a wireless personal-area network transceiver adapted for wireless communication with the motion monitor, a memory adapted to store workout program data, a processor adapted to determine performance information for the individual, and an output adapted to provide feedback to the individual based on the performance information and the workout program data.

Abstract: Disclosed herein are methods of detecting differential over-expression of 3? exons relative to 5? exons of the Neurotrophic Tyrosine Receptor Kinase (NTRK) gene to facilitate the identification of subjects having NTRK fusion proteins. Additionally, methods of treating cancer by administering NTRK inhibitors to a subject identified as having tumors which express NTRK fusion protein, are also disclosed.

Abstract: Disclosed herein are methods for identifying mutations from a patient sample, by evaluating, using a computer having a machine learning classifier, a candidate variant against a plurality of decision trees trained to detect mutations in the candidate variant with a gradient boosting algorithm.

Abstract: A latch (10) is usable to selectively hold a closure member such as a door (188) in a closed position. The latch includes a body (12) which has a manually engageable handle (18) on a front side thereof. A shank (30) is in rotationally movable connection with the handle. The shank extends through the body and into an indexing cam bore (58) on the back side of the body. The shank is both axially and rotationally movable about a cam bore axis (62). An indexing cam (88) is connected to the shank. The shank is in operative connection with a striker (102). The striker is rotationally movable responsive to rotation of the handle between a latched position and unlatched position when the shank is in a second axial position. When the shank is in a first axial position, the shank is held in a fixed rotational position by the indexing cam, and the striker is held in the latched position. A cam bolt (164) is movably engageable with the striker to hold the striker in the latched position.

Abstract: The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.

Abstract: Disclosed herein are methods of assessing whether a subject would be responsive to an immunotherapy.

Abstract: An exemplary hinge (36, 88) is used to connect a body door (84, 162) in movable operative connection with a body (12, 102). The hinge enables selectively moving the door to open and close a body opening (82, 164). The hinge includes a primary hinge butt (38, 90) which includes a primary hinge butt knuckle (40, 104). A primary hinge strap (60, 114) includes a primary hinge strap knuckle (62, 116) which enables relative rotational movement of the primary hinge butt and the primary hinge strap. The door is in operatively attached connection with the primary hinge strap. A secondary hinge butt (132) may be in operative connection with the primary hinge strap to enable relative rotational movement of the door relative to the primary hinge strap in the hinge open position. A disengageable latch may be used to hold the secondary hinge butt in a fixed rotational position.

Abstract: A data processing system includes a processor and associated memory implementing an enterprise data management (EDM) module configured to interact with an enterprise management system. A storage device coupled to the processor, implements an enterprise data management (EDM) database, which stores priority rules used to determine priority scores associated with a plurality of different entities associated with entity records. A communications interface coupled to the processor, transmits the priority rules, to an enterprise management system, and receives priority scores of individual entities, determined based on the priority rules, from the enterprise management system. The priority scores of the individual entities are stored in the EDM database in association with the priority rules, and the EDM module matches the entity records to entities based, at least in part, on the priority scores of the individual entities.

Abstract: A system includes a temperature control system configured to couple to an air intake section of a gas turbine system. The temperature control system includes a variable heating system having one or more heaters configured to heat an airflow in the air intake section when the airflow is cooled by an evaporative cooling system. The temperature control system is configured to control the variable heating system to vary an amount of heat supplied by the one or more heaters based on at least one temperature measurement relative to a temperature threshold.

Abstract: Systems with methods of providing a strategic poker tournament for 3-9 players, utilising a sequentially programmed electronic microprocessor, downloadable on ‘smart’ devices or in another embodiment, on gaming tables or gaming machines, known as “Tennessee Hold 'Em® Tournaments”, are defined: These methods provide beneficial stimulation of participants' cognitive brain activity through prompted continuous strategic thought. Systems include a bespoke method of “loaning” chips which eliminates inequitable ‘side pots’. Systems exclude players holding 4 hole cards from using the final community card, and Players holding 5 hole cards from using the penultimate and final card distributions, so participants create their own strategy. Prizes are awarded when two players remain. Chips are totaled and the winner's chips are divided by the total chips to determine the percentage split between the finalists.

Abstract: A method of detecting flame state of a combustor of a turbine engine. The method includes determining at least one of a first derivative and a second derivative of a compressor discharge pressure of a compressor of the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine exhaust gas temperature of the exhaust gases output by the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine shaft/rotor speed of the turbine engine; determining at least one of a first derivative and a second derivative of combustor dynamic pressure monitoring; and determining a flame state of a combustor of the turbine engine based on the combustor dynamic pressure monitoring, the determined derivatives of the combustion dynamics, compressor discharge pressure, gas turbine shaft/rotor speed, and gas turbine exhaust gas temperature of the exhaust gases.

Abstract: A method of detecting flame state of a combustor of a turbine engine. The method includes determining at least one of a first derivative and a second derivative of a compressor discharge pressure of a compressor of the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine exhaust gas temperature of the exhaust gases output by the turbine engine; determining at least one of a first derivative and a second derivative of a gas turbine shaft/rotor speed of the turbine engine; determining at least one of a first derivative and a second derivative of combustor dynamic pressure monitoring; and determining a flame state of a combustor of the turbine engine based on the combustor dynamic pressure monitoring, the determined derivatives of the combustion dynamics, compressor discharge pressure, gas turbine shaft/rotor speed, and gas turbine exhaust gas temperature of the exhaust gases.

Abstract: A latch (10,120,200) includes a rotatable jaw (18, 124, 204) that engages and holds a striker (32,128,210) in a latched position. A rotatable pawl (28, 132, 214) in an engaged position is operative to hold the jaw in the latched position. Movement of the pawl to a disengaged position enables the jaw to move to an unlatched position and to disengage the striker. The pawl is movable from the engaged position to the disengaged position through operation of either an electrical actuator (84, 152, 236) or through movement of an actuating end (26, 142, 224) of the pawl by a cable or similar mechanical connector (36, 246).

Abstract: A latch (10) includes a rotatable jaw (18) that engages and holds a striker (32) in a latched position. A rotatable pawl (28) in an engaged position is operative to hold the jaw in the latched position. Movement of the pawl to a disengaged position enables the jaw to move to an unlatched position and to disengage the striker. The pawl is movable from the engaged position to the disengaged position through operation of either an electrical actuator (84) or through movement of an actuating end (26) of the pawl by a cable (36).

Abstract: A latch (10) includes a rotatable jaw (18) that engages and holds a striker (32) in a latched position. A rotatable pawl (28) in an engaged position is operative to hold the jaw in the latched position. Movement of the pawl to a disengaged position enables the jaw to move to an unlatched position and to disengage the striker. The pawl is movable from the engaged position to the disengaged position through operation of either an electrical actuator (84) or through movement of an actuating end (26) of the pawl by a cable (36).

Abstract: A data processing system includes a processor and associated memory implementing an enterprise data management (EDM) module configured to interact with an enterprise management system. A storage device coupled to the processor, implements an enterprise data management (EDM) database, which stores priority rules used to determine priority scores associated with a plurality of different entities associated with entity records. A communications interface coupled to the processor, transmits the priority rules, to an enterprise management system, and receives priority scores of individual entities, determined based on the priority rules, from the enterprise management system. The priority scores of the individual entities are stored in the EDM database in association with the priority rules, and the EDM module matches the entity records to entities based, at least in part, on the priority scores of the individual entities.

Abstract: Described herein are systems and methods relating to cellular micro-masonry. Systems and methods as described herein allow a user to create three-dimensional (3D) structures of cells disposed in a 3D culture medium. Systems and methods as described herein provide for the manipulation and construction of cellular structures on a single, cell-by-cell, basis.

Abstract: Disclosed herein are methods of detecting and treating checkpoint inhibitor responsive cancers comprising calculating, determining, or obtaining PD-L1 expression, CD8A expression, and tumor content from a cancer specimen.