Abstract: A package fabricated from a flexible sheet material capable of being sealed for closing off the interior of the package from ambient atmosphere is disclosed. The package has two or more side walls and a like number of side seams. The package has an open upper end portion terminating in a free edge. The inner surface of the side walls has a releasably securable adhesive adjacent the upper end portion in a pattern wherein the adhesive does not extend into the area of the side seams, thus increasing the structural integrity of the package.

Abstract: A convertible package having an interior for holding a flowable product, e.g., a powder or granular material. The package includes at a front panel, a rear panel, and a removable covering. The front and rear panels are formed of a flexible sheets having a peripheral edge along which the panels are heat sealed to form the package's hollow interior. The removable cover is made up of a front cover sheet and a rear cover sheet, which are formed of a flexible material and are of a sufficient extent to encompass the entire area of the front panel and rear panels, respectively. The cover sheets are releasably secured along their periphery to respective ones of the packages front and rear panels to effectively isolate those panels from the ambient surroundings. The two cover sheets are arranged to be peeled off the panels, leaving the front and rear panels secured together with the product sealed within the hollow interior of the package.

Abstract: A snap closure for a flexible, gusseted package and a flexible gusseted packing including the closure. The package includes a mouth portion arranged to be opened to provide access to the contents of the package. The package is formed of a flexible material and includes a front panel, a rear panel, and a pair of opposed side gussets. The panels and gussets each include a top portion, which between them define the package's mouth. The package's mouth is initially sealed but arranged to be opened, e.g., peeled apart. The snap closure enables the resealing of the mouth of the package and is made up of a pair of elongated elements, one of which includes a tongue extending along the length of it. The other element includes an undercut groove extending along the length of it. The elements are arranged to be pressed together, whereupon the tongue of the one element enters the groove of the other element with portions of the panels and side gussets tightly interposed therebetween.

Abstract: A snap closure for a flexible, gusseted package and a flexible gusseted packing including the closure. The package includes a mouth portion arranged to be opened to provide access to the contents of the package. The package is formed of a flexible material and includes a front panel, a rear panel, and a pair of opposed side gussets. The panels and gussets each include a top portion, which between them define the package's mouth. The package's mouth is initially sealed but arranged to be opened, e.g., peeled apart. The snap closure enables the resealing of the mouth of the package and is made up of a pair of elongated elements, one of which includes a tongue extending along the length of it. The other element includes an undercut groove extending along the length of it. The elements are arranged to be pressed together, whereupon the tongue of the one element enters the groove of the other element with portions of the panels and side gussets tightly interposed therebetween.

Abstract: This invention relates to a series of substituted imidazoles of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.

Abstract: A package fabricated from a flexible sheet material capable of being sealed for closing off the interior of the package from ambient atmosphere is disclosed. The package has two or more side walls and a like number of side seams. The package has an open upper end portion terminating in a free edge. The inner surface of the side walls has a releasably securable adhesive adjacent the upper end portion in a pattern wherein the adhesive does not extend into the area of the side seams, thus increasing the structural integrity of the package.

Abstract: A dispensing package formed of a flexible material, e.g., a plastic film or laminate, and having two separate compartments for holding paste-like materials therein until they are to be dispensed together from the package. The package also includes an outlet in the form of a fitment having a removable cap coupled to the two compartments. The first compartment is formed by an outer panel of the package and one section of a gusset panel which forms a first inner panel. The second compartment is formed by another outer panel of the package an another section of the gusset panel which forms a second inner panel. One outer panel and its immediately adjacent inner panel are secured together along their bottom marginal edges. The other outer panel and its immediately adjacent outer panel are welded together along their bottom marginal edges.

Abstract: A hermetic package for fine particulate material. The package is arranged to be filled and vacuumized to hold the fine particulate material therein and isolated from the ambient atmosphere. The package, which may be in the form of a pouch or a gussetted packages, is formed of a flexible material to have at least a front and a rear panel. At least one degassing valve is mounted in at least one of the panels to enable gas within the interior of the package to vent to the ambient atmosphere. A filter sheet, e.g., a spun-bonded plastic, such as Tyvek.RTM., is secured to the interior of the package over the valve to prevent the fine particulate material within the package from entering into the valve and clogging it. The filter sheet may cover only a small portion of one of the panels of the package or may cover a major portion of that panel, or even cover substantially the entire interior of the package. The package includes a top portion forming a mouth, which is arranged to be opened, e.g.

Abstract: This invention relates to substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them, methods of using them and intermediates useful in their manufacture. The compounds of the invention modulate the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with the production of inflammatory cytokines.

Abstract: A package for holding abrasive, greasy or oily material, such as dry pet food. The package is formed of a web of flexible material and has an outer surface and an inner surface. The web comprising plural layers adhesively secured to one another. The layers are in sequence from the outer surface of the package to the inner surface thereof. The sequence of layers is a first film layer formed of a heat resistant and temperature resistant material, e.g., polyester film, a second layer formed of a shock-absorbing and heat resistant paper, e.g., Kraft paper, a third film layer formed of a puncture resistant, heat resistant barrier material, e.g., nylon, which also forms a gas and chemical barrier, and a fourth film layer formed of a moisture resistant sealable film material, polyethylene. The outer layer is transparent and indicia is provided between it and the paper layer so that the indicia is visible through the outer layer.

Abstract: Benzyl-phosphonate compounds represented by the formula I: ##STR1## are disclosed as useful in treating bone wasting diseases and as an immunosuppresant.

Abstract: This invention relates to a series of substituted imidazoles of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention inhibit the production of a number of inflammatory cytokines, and are useful in the treatment of diseases associated with overproduction of inflammatory cytokines.

Abstract: A flexible, gussetted package and method of making it. The package has an interior for initially holding some product, e.g., whole coffee bean or ground coffee, under vacuum, and which includes a mouth portion arranged to be peeled open to provide access to the contents of the package. The package is formed of a flexible material and includes a front panel, a rear panel, and a pair of opposed side gussets. The panels and gussets each include a top portion, which between them define the package's mouth. A peelable closure is provided within the mouth. A snap closure is provided above the peelable closure. The package is arranged to be sealed under vacuum, with the peelable closure maintaining the vacuum within the package until it is peeled open. The snap closure comprises a pair of snap strip members secured to respective portions of the front and rear panel.

Abstract: Compounds represented by the formula I: ##STR1## are disclosed as agents for use in treating bone wasting diseases.