Abstract: The invention relates to 4-((6-(2,2-Difluoroethyl)-8-(2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidine-1-sulfonamide or pharmaceutically acceptable salts thereof, to compositions containing them, to processes for their preparation, to intermediates used in such processes, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer. The disclosure also relates to its crystalline form 1, to pharmaceutical compositions comprising form 1, and to the use of form 1 for the treatment of cancers.

Abstract: A structural assembly for an electric vehicle includes a vehicle frame, a battery structure, a pair of mounting structures, and a plurality of fasteners. The vehicle frame includes opposed longitudinal rails. The battery structure is disposed between the opposed longitudinal rails and includes a battery housing configured to house power storage units. Each mounting structure is secured to a respective side of the battery housing and supports a corresponding longitudinal rail. The plurality of fasteners extend through a corresponding mounting structure of the pair of mounting structures and a corresponding longitudinal rail of the opposed longitudinal rails to secure the vehicle frame and the battery structure to each other. An outer periphery of the corresponding mounting structure is substantially flush with an outer periphery of the corresponding longitudinal rail.

Abstract: A structural assembly for an electric vehicle includes a vehicle frame and a battery structure. The vehicle frame is distinct from a vehicle body and includes a front section, a rear section and a mid-section disposed between the front and rear sections. The mid-section includes opposed longitudinal rails. The battery structure is configured to house power storage units and is disposed between the opposed longitudinal rails. The battery structure includes a battery housing secured to the opposed longitudinal rails of the mid-section. The mid-section and the battery housing are combined into a unitized structure that is removably secured to the front and rear sections of the vehicle frame.

Abstract: A system for an electrophotographic image forming device includes a toner container having a reservoir for storing toner and an impact member configured to selectively impart an impulse force on the toner container to cause vibration of the toner container. A sensor is configured to sense the vibration of the toner container upon the impact member imparting the impulse force on the toner container. Processing circuitry in communication with the sensor is configured to determine an estimate of an amount of toner in the reservoir based on the sensed vibration of the toner container.

Abstract: A system for sensing material within a container includes a container having a reservoir for storing material and an impact member configured to selectively impart an impulse force on the container to cause vibration of the container. A sensor is configured to sense the vibration of the container upon the impact member imparting the impulse force on the container. Processing circuitry in communication with the sensor is configured to determine an estimate of an amount of the material in the container based on the sensed vibration of the container.

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, and a fluid flow path. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container and a valve assembly. The fluid flow connection is coupled with the container and the needle insertion mechanism and is adapted to allow the medicament to flow from the container to the needle insertion mechanism. The valve assembly is repeatedly movable between at least a valve open position and a valve closed position to selectively allow and restrict the medicament to flow through the needle and/or the cannula.

Abstract: In various embodiments, an energy storage mounting system includes an inverter wall bracket mounted to a wall, wherein an inverter is coupled to the inverter wall bracket. The system includes a battery wall bracket to which a battery block is coupled. The battery wall bracket interfaces with an auxiliary bracket that is mounted to the wall, is vertically translatable relative to the auxiliary bracket, and is at least in part ground-supported. The battery block is electrically connected to the inverter.

Abstract: A method for treating a patient using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The needle extends through the catheter such that a distal end of the needle extends distal of a distal end of the catheter. The guidewire is coupled to the thumbwheel such that rotation of the thumbwheel advances a distal end of the guidewire through a lumen of the needle. The method includes holding the catheter insertion device, inserting the distal end of the needle and catheter into a blood vessel, rotating the thumbwheel to advance the distal end of the guidewire out of the lumen of the needle into the blood vessel, moving the catheter over the guidewire in the blood vessel, and removing the needle and the guidewire from the catheter.

Abstract: An anti-polish ring for an internal combustion engine is provided. The anti-polish ring includes an axially extending ring portion that is configured to scrape a top portion of a piston in a cylinder liner. The anti-polish ring is configured to accommodate passage of an intake or exhaust valve thereby. The anti-polish ring may include an alignment feature so that the anti-polish ring is inserted in a predetermined orientation in the cylinder. The anti-polish ring may include a heat shield and/or a seating member.

Abstract: A drug delivery device for delivering a medicament includes a pump first housing, a pump second housing, an inlet fluid path, and an outlet fluid path. The pump first housing is at least partially supporting and/or surrounding a fluid displacement assembly. The pump second housing is at least partially supporting and/or surrounding a drive component for driving the fluid displacement assembly. The inlet fluid path is configured to deliver medicament to the fluid displacement assembly. The outlet fluid path is configured to receive medicament from the fluid displacement assembly. The pump first housing and the pump second housing are removably coupled with each other.

Abstract: A system for sensing material within a container includes a container having a reservoir for storing material and an impact member configured to selectively impart an impulse force on the container to cause vibration of the container. A sensor is configured to sense the vibration of the container upon the impact member imparting the impulse force on the container. Processing circuitry in communication with the sensor is configured to determine an estimate of an amount of the material in the container based on the sensed vibration of the container.

Abstract: A system for an electrophotographic image forming device includes a toner container having a reservoir for storing toner and an impact member configured to selectively impart an impulse force on the toner container to cause vibration of the toner container. A sensor is configured to sense the vibration of the toner container upon the impact member imparting the impulse force on the toner container. Processing circuitry in communication with the sensor is configured to determine an estimate of an amount of toner in the reservoir based on the sensed vibration of the toner container.

Abstract: A derivatizing reagent, set of derivatizing reagents, and derivatizing techniques are provided herein for the relative quantitation, absolute quantitation, or both, of analytes containing carboxyl and/or phenolic functional groups including those analytes that may be difficult to analyze via mass spectrometry using traditional techniques of ionization. By way of non-limiting examples, such analytes can include fatty acids, carnitines, eicosanoids, and estrogens. Methods for producing the derivatizing reagent are also disclosed.

Abstract: A system can include a gateway, a plurality of network function nodes, and a distributed load balancer including load balancer nodes each having a flow table portion stored thereon. The load balancer nodes can form a node chain having a tail and head nodes. A load balancer node can receive a packet from the gateway. In response, the load balancer node can generate a query, directed to the tail node, that identifies the packet and a network function identifier associated with a network function node that is proposed to handle a connection. The tail node can determine whether an entry for the connection exists in a flow table portion associated with the tail node. If not, the tail node can initiate an insert request for writing the entry for the connection via the head node. The entry can then be written to all load balancer nodes in the node chain.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to monitor a split screen media presentation. Example apparatus includes means for processing audio output from a media device to determine audio metering data to identify first media presented by the media device, means for generating one or more video signatures associated with video output from the media device, and means for identifying a first region-of-interest of a split screen presentation of the media device including the first media, the means for identifying to identify the first region-of-interest in response to a determination that the one or more generated video signatures do not match reference video signatures corresponding to the first media.

Abstract: A system can include a gateway, a plurality of network function nodes, and a distributed load balancer including load balancer nodes each having a flow table portion stored thereon. The load balancer nodes can form a node chain having a tail and head nodes. A load balancer node can receive a packet from the gateway. In response, the load balancer node can generate a query, directed to the tail node, that identifies the packet and a network function identifier associated with a network function node that is proposed to handle a connection. The tail node can determine whether an entry for the connection exists in a flow table portion associated with the tail node. If not, the tail node can initiate an insert request for writing the entry for the connection via the head node. The entry can then be written to all load balancer nodes in the node chain.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to monitor a split screen media presentation. Example apparatus disclosed herein are to generate one or more video signatures associated with video output from a media device and determine whether the one or more video signatures correspond to first media identified based on audio output from the media device. Disclosed example apparatus are also to, in response to a determination that the one or more generated video signatures do not correspond to the first media, determine that the video corresponds to a split-screen presentation having a plurality of regions-of-interest, and identify a first one of the regions-of-interest of the split-screen presentation that includes the first media.

Abstract: A retractable load carrier system for a vehicle comprising a rail assembly comprising a first rail and a second rail, wherein each rail is configured to be mounted to a vehicle roof. The system can further include a rack assembly comprising a first support member and a second support member generally parallel to each other, wherein the first support member and second support member can be coupled together with at least one cross members, wherein the rack assembly has a first end and a second end, wherein both the first and second end can include a handle portion. A locking means can be coupled to the handle portion of the rack assembly, wherein the locking means comprises a plurality of engagement members configured to latch to engage the grooved portion of the rail assembly or the pins are configured to engage the pinion portion of the rail assembly.

Abstract: Provided is a toner blend composition comprising a first pigmented toner and a second toner that is devoid of any pigment additive, i.e., a ‘non-pigmented or clear toner’. The non-pigmented or clear toner is about 1% to about 15% by weight of the toner blend composition. The resulting inventive toner blend composition surprisingly exhibits similar print density on a page compared to a fully pigmented toner. Moreover, this toner blend composition exhibits improvement in toner usage per page, thus lowering toner cost compared to a fully pigmented toner. The non-pigmented or clear toner may be used in combination with either a monochrome or conventional toner using a carbon black pigment, or a chemically processed toners (‘CPT”) toners using a black pigment, magenta pigment, yellow pigment or a cyan pigment.

Abstract: Provided is a toner blend composition comprising a first pigmented toner and a second toner that is devoid of any pigment additive, i.e., a ‘non-pigmented or clear toner’. The non-pigmented or clear toner is about 1% to about 15% by weight of the toner blend composition. The resulting inventive toner blend composition surprisingly exhibits similar print density on a page compared to a fully pigmented toner. Moreover, this toner blend composition exhibits improvement in toner usage per page, thus lowering toner cost compared to a fully pigmented toner. The non-pigmented or clear toner may be used in combination with either a monochrome or conventional toner using a carbon black pigment, or a chemically processed toners (‘CPT?’) toners using a black pigment, magenta pigment, yellow pigment or a cyan pigment.