Patents by Inventor Scott A. Fowler
Scott A. Fowler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230312341Abstract: A method of generating hydrogen from an offgas includes obtaining the offgas from a renewable diesel unit (RDU). The method further includes inputting the offgas to a steam methane reformer (SMR).Type: ApplicationFiled: April 3, 2023Publication date: October 5, 2023Inventors: Bruce A. FLEMING, Michael WOJCIECHOWSKI, Ron COLWELL, Eric SCHULE, Scott FOWLER, Vinay KHURANA, Abhijeet KARNIK, Eric WAGNER
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Patent number: 11224643Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: May 14, 2019Date of Patent: January 18, 2022Assignee: CSL Behring L.L.C.Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Patent number: 11071364Abstract: An armband holder for a personal electronic device is capable of being secured about the arm of a user by means of an adjustable band. Adjacent the elastic holder for an electronic device is an elastic holster configured to removably secure a canister of pepper spray therein.Type: GrantFiled: June 12, 2020Date of Patent: July 27, 2021Inventor: Scott A. Fowler
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Publication number: 20200078451Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: May 14, 2019Publication date: March 12, 2020Inventors: Scott M. KEE, Paul I. COOK, James R. SMITH, Robert KLING, Scott A. FOWLER, David WEBER
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Patent number: 10335467Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: March 12, 2018Date of Patent: July 2, 2019Assignee: CSL Behring L.L.C.Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Publication number: 20180200347Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: March 12, 2018Publication date: July 19, 2018Inventors: Scott M. KEE, Paul I. COOK, James R. SMITH, Robert KLING, Scott A. FOWLER, David WEBER
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Patent number: 9950046Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: March 18, 2016Date of Patent: April 24, 2018Assignee: CSL Behring L.L.C.Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Publication number: 20170042986Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: March 18, 2016Publication date: February 16, 2017Inventors: Scott M. KEE, Paul I. COOK, James R. SMITH, Robert KLING, Scott A. FOWLER, David WEBER
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Patent number: 9320783Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: July 17, 2015Date of Patent: April 26, 2016Assignee: CSL Behring L.L.C.Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Publication number: 20150320846Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: July 17, 2015Publication date: November 12, 2015Inventors: Scott M. KEE, Paul I. COOK, James R. SMITH, Robert KLING, Scott A. FOWLER, David WEBER
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Publication number: 20140323405Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: March 24, 2014Publication date: October 30, 2014Applicant: CSL Behring L.L.C.Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Patent number: 8722624Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: February 28, 2012Date of Patent: May 13, 2014Assignee: CSL Behring LLCInventors: Scott M Kee, Paul I Cook, James R Smith, Robert Kling, Scott A Fowler, David Weber
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Publication number: 20120165261Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: February 28, 2012Publication date: June 28, 2012Applicant: CSL BEHRING LLCInventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Patent number: 8124736Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: August 13, 2010Date of Patent: February 28, 2012Assignee: CSL Behring L.L.C.Inventors: Scott M Kee, Paul I. Cook, James R Smith, Robert Kling, Scott A Fowler, David Weber
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Publication number: 20100310550Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: August 13, 2010Publication date: December 9, 2010Applicant: CSL BEHRING L.L.C.Inventors: SCOTT M. KEE, PAUL I. COOK, JAMES R. SMITH, ROBERT KLING, SCOTT A. FOWLER, DAVID WEBER
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Patent number: 7777006Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: December 31, 2002Date of Patent: August 17, 2010Assignee: CSL Behring L.L.C.Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Publication number: 20080237165Abstract: In some embodiments, a shelving system configured to be coupled to a wall and supported on a support surface is provided. The shelving system can include a fixed shelving unit extending laterally from the wall, and a movable shelving unit. The fixed shelving unit can include a vertical support coupled to a base. The movable shelving unit can also extend laterally from the wall, and can be movable through a shelving path. In some embodiments, the shelving system can be provided with a floor leveling system enabling a user to easily and quickly level the shelving system. Also, in some embodiments, the movable shelving unit includes a damper that slows the movable shelving unit prior to being stopped.Type: ApplicationFiled: June 9, 2008Publication date: October 2, 2008Inventors: Arthur H. Bobis, Winston Scott Fowler, Phillip Allan Rosenband
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Publication number: 20040124143Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: ApplicationFiled: December 31, 2002Publication date: July 1, 2004Inventors: Scott M. Kee, Paul I. Cook, James R. Smith, Robert Kling, Scott A. Fowler, David Weber
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Patent number: 4653499Abstract: An electrode for use in miniaturized sensor applications includes an electrically conductive element, a first layer of a salt on the surface of the conductive element having a common cation with the conductive element, a second layer of a second salt coating the first layer, the second layer having a common anion with the first layer, and a membrane covering the second layer, wherein the electrode is completely anhydrous when formed. The membrane may be selected to form either an ion selective electrode or a reference electrode.Type: GrantFiled: February 7, 1985Date of Patent: March 31, 1987Assignee: Gould Inc.Inventors: Richard C. Murray, Jr., J. Scott Fowler, Mark S. Goorsky
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Patent number: D850729Type: GrantFiled: March 8, 2018Date of Patent: June 4, 2019Inventor: Scott A. Fowler