Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA,

Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of ?-hydroxy carboxylic acid is produced by converting a lower alkyl ester of ?-hydroxy carboxylic acid into a fatty alcohol ester of ?-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants.

Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of ?-hydroxy carboxylic acid is produced by converting a lower alkyl ester of ?-hydroxy carboxylic acid into a fatty alcohol ester of ?-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One preferred way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as soon as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants (e.g., adding more of the starting ester).

Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of ?-hydroxy carboxylic acid is produced by converting a lower alkyl ester of ?-hydroxy carboxylic acid into a fatty alcohol ester of ?-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One preferred way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as soon as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants (e.q., adding more of the starting ester).

Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.

Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.

Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. The present invention also provides a novel topical gel for the transdermal delivery of steroids using the fatty alcohol esters as permeation enhancers.

Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of ?-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of ?-hydroxy carboxylic acid is produced by converting a lower alkyl ester of ?-hydroxy carboxylic acid into a fatty alcohol ester of ?-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One preferred way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as soon as it is formed). Another preferred way of shifting the reaction in-the direction of the desired product is by increasing the concentration of one of the reactants (e.q., adding more of the starting ester).

Abstract: The present invention is directed to a brazing sheet comprising an aluminum 3xxx series core alloy wherein at least one side thereof is provided with an aluminum clad material comprising from 0.7-2.0% Mn and 0.7-3.0.0% Zn, wherein the clad is capable of being used as an Inner-liner of a heat exchange product. In one embodiment one side of the core alloy is provided a material that comprises from 0.7-2.0% Mn and 0.7-3.0% Zn and the other side of the core is provided with an aluminum alloy comprising at least 5.5% Si. Thee are further provided methods for preparing brazing sheets as described herein as well as methods for use of brazing sheet materials including as tube stock and as heat exchangers, as well as other applications.

Abstract: The present invention provides an aluminum alloy brazing sheet material, particularly suitable for charge air cooler applications, comprising a core alloy and a clad brazing alloy, as well as to methods for their manufacture and use. The present invention also provides a method for increasing the yield strength of brazing sheet materials.

Abstract: The present invention provides aluminum alloys and layers formed in aluminum alloys as well as methods for their manufacture. Aluminum alloys of the present invention are provided with at least one discrete layer of uncrystallized grains formed therein. Alloys of the present invention can be formed, for example, by a process that includes a final partial anneal that permits softening of the material to essentially an O-temper condition. Processes of the present invention recrystallized substantially the entire material by leave a discrete layer of preferably less than 50 microns of the material unrecrystallized. In preferred embodiments, the aluminum material is a core material that is clad on one or both sides and the discrete unrecrystallized layer forms at the boundary between the clad and the core.

Abstract: The present invention is directed to a brazing sheet comprising an aluminum 3xxx series core alloy, wherein at least one side thereof is provided with an aluminum clad material comprising 0.7-2.0% Mn and 0.7-3.0% Zn, wherein the clad is capable of being used as an inner-liner of a heat exchanger product. In one embodiment, one side of the core alloy is provided with a material that comprises 0.7-2.0% Mn and 0.7-3.0% Zn and the other side of the core is provided with an aluminum alloy comprising at least 5.5% Si. There are further provided methods for preparing brazing sheets as described herein as well as methods for use of brazing sheet materials including as tube stock and as heat exchangers, as well as other applications.

Abstract: The present invention provides an aluminum alloy brazing sheet material, particularly suitable for charge air cooler applications, comprising a core alloy and a clad brazing alloy, as well as to methods for their manufacture and use. The present invention also provides a method for increasing the yield strength of brazing sheet materials.

Abstract: The present invention is directed to a brazing sheet comprising an aluminum 3xxx series core alloy, wherein at least one side thereof is provided with an aluminum clad material comprising 0.7-2.0% Mn and 0.7-3.0% Zn, wherein the clad is capable of being used as an inner-liner of a heat exchanger product. In one embodiment, one side of the core alloy is provided with a material that comprises 0.7-2.0% Mn and 0.7-3.0% Zn and the other side of the core is provided with an aluminum alloy comprising at least 5.5 % Si.