Abstract: Herein are provided anti-EGFR single domain antibodies (sdAb) prepared by immunizing a llama with recombinant human EGFRvIII. VHH antibodies specific to EGFR were isolated. The example antibodies initially produced comprise CDR1, CDR2, and CDR3 sequences corresponding, respectively to SEQ NOs: 1-3, 4-6, 7-9, 10-12, 13-15, 16-18, 19-21, 22-24, 25-27, 28-30, 31-33, 34-36, 37-39, 40-42, 43-45, and 46-48; and related sequences, including humanized variants. Also provided are multivalent antibodies comprising any one of the sdAbs, including bispecific T-cell engagers, bispecific killer cell engagers (BiKEs), and trispecific killer cell engagers (TriKEs). Also described are chimeric antigen receptors (CARs) for CAR-T therapy comprising any one of the aforementioned sdAbs. Uses of these molecules in the treatment of cancer are also described, in particularly EGFR-high cancers. Hinge lengths may be selected to achieve desired activities, such as high activity or high selectivity for target vs. non-target cells.

Abstract: This disclosure relates to an irrigation system pipe joint or span coupling, which can connect a span of an irrigation system to another structure. In examples, the joint can include various components that attach an end of a first pipe or joint to an end of a second pipe or joint. For example, the end of the first joint can include a receiver plate, which can include a recess with a bushing. In addition, the end of the second joint can include a post, hook, or other elongated member that, in order to connect the first joint to the second joint, is insertable into the bushing.

Abstract: An oscillating heat pipe (OHP) device that comprise a body having a top face, a bottom face and at least one side face, a plurality of hollow OHP channels formed internally within the body, and an oscillating heat pipe (OHP) flushing duct system. The flushing duct system is formed in at least one of a body top face, a bottom face and at least one side face of an OHP device. The flushing duct system fluidly connects one or more of a plurality of OHP channels formed internally within the OHP device to an ambient environment of the device. The flushing duct system comprising at least one welding receptacle.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include a connector port subassembly. The connector port subassembly may include one or more connector blocks configured to interference fit within a connector bore, one or more windows through the core subassembly to the one or more connector blocks, and one or more seal rings configured to interference fit within the connector bore and eliminate adulterant entry into the connector bore through the one or more windows.

Abstract: An irrigation system having a pipeline supported by one or more towers includes an improved truss connection system having a means for readily adjusting a crown height of the pipeline. A pair of cooperating members define a joint which selectively couples headed ends of adjacent truss rods together to form a truss rail of a truss system that supports the pipeline. A single fastener may fasten the cooperating members, a strut, and a cross-member together at the joint. A length of the truss rail may be decreased by holding the truss rods closer together. In an aspect, the headed ends of the adjacent truss rods are held closer together by inserting a shim in one of the joints. Decreasing the length of the truss rail increases the deflection of the pipeline and raises the crown height.

Abstract: Processed lignin comprising the elements carbon (C), hydrogen (H) and oxygen (O) in the following amounts (upon performing an elemental analysis): carbon in an amount of between 60 and 85% by weight, hydrogen in an amount of between 3.0 and 6.0% by weight, oxygen in an amount of between 10 and 29% by weight, wherein the weight ratio carbon/hydrogen C/H is at least 12.5 and the ratio C/O is at least 2.5, and wherein the processed lignin comprises less than 0.1% by weight of total CI, wherein it has a sulphur content of below 1 g/kg and wherein the moisture content of it is less than 3% by weight. The invention further relates to a process to prepare such. Such process involves the steps of subjecting particles comprising lignin and cellulose and optionally hemicellulose to acidic hydrolysis using hydrochloric acid of at least 35%, subjecting the obtained residue to a high temperature treatment of between 300 and 500° C. under inert gaseous atmosphere to a total CI level of below 0.

Abstract: A device includes a display, a camera, a memory storing a software code, and a hardware processor configured to execute the software code to: configure the device to be in a first mode; receive, from the camera, camera data of an environment surrounding the device; determine that a person is present in the environment based on the camera data; determine that the person is facing the display based on the camera data; and transition the device from the first mode to a second mode, in response to determining that the person is facing the display. The display displays a first content when the device is in the first mode, and displays a second content different than the first content when the device is in the second mode. The second content is configured to provide information about the device to the person without requiring the person to touch the device.

Abstract: Methods and apparatus for localized processing within multicore neural networks. Unlike existing solutions that rely on commodity software and hardware to perform “brute force” large scale neural network processing the various techniques described herein map and partition a neural network into the hardware limitations of a target platform. Specifically, the various implementations described herein synergistically leverage localization, sparsity, and distributed scheduling, to enable neural network processing within embedded hardware applications. As described herein, hardware-aware mapping/partitioning enhances neural network performance by e.g., avoiding pin-limited memory accesses, processing data in compressed formats/skipping unnecessary operations, and decoupling scheduling between cores.

Abstract: A device includes a display, a camera, a memory storing a software code, and a hardware processor configured to execute the software code to: configure the device to be in a first mode; receive, from the camera, camera data of an environment surrounding the device; determine that a person is present in the environment based on the camera data; determine that the person is facing the display based on the camera data; and transition the device from the first mode to a second mode, in response to determining that the person is facing the display. The display displays a first content when the device is in the first mode, and displays a second content different than the first content when the device is in the second mode. The second content is configured to provide information about the device to the person without requiring the person to touch the device.

Abstract: The present disclosure relates to the field of plant molecular biology, more particularly to regulation of gene expression in plants.

Abstract: The present disclosure relates to the field of plant molecular biology, more particularly to regulation of gene expression in plants.

Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.

Abstract: A device for measuring a flange in a creased sheet of metal is provided, along with a method of use thereof. The device includes a block including at least two slots and a body extending from the block in a first direction. The device also includes at least two retractable teeth. Each tooth is mounted in a respective one of the at least two slots. Each tooth is biased toward the first direction and retractable in a second direction opposite the first direction. A foot is mounted to an end of the body and includes a groove configured to receive an edge of the sheet of metal. A free edge of the flange is received in the groove and a creased edge is retained by the teeth. The flange may be measured by inserting a depth gauge through the block to a surface of the sheet of metal.

Abstract: A device for measuring a flange in a creased sheet of metal is provided, along with a method of use thereof. The device includes a block including at least two slots and a body extending from the block in a first direction. The device also includes at least two retractable teeth. Each tooth is mounted in a respective one of the at least two slots. Each tooth is biased toward the first direction and retractable in a second direction opposite the first direction. A foot is mounted to an end of the body and includes a groove configured to receive an edge of the sheet of metal. A free edge of the flange is received in the groove and a creased edge is retained by the teeth. The flange may be measured by inserting a depth gauge through the block to a surface of the sheet of metal.

Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.