Abstract: The present disclosure provides antibodies to V-domain Ig-containing Suppressor of T cell Activation (VISTA) and compositions comprising such antibodies. Also provided are methods of using antibodies that specifically binds to VISTA to treat diseases, e.g., to treat cancer.

Abstract: Methods of operating a refrigerator appliance are provided. The refrigerator appliance includes a cabinet defining a food storage chamber with a drawer slidably mounted within the food storage chamber. The refrigerator appliance also includes a sensor operable to detect an atmospheric condition within the food storage chamber of the drawer and a camera assembly positioned and configured for monitoring the drawer. The methods generally include obtaining an image using the camera assembly and analyzing the image to identify a first food item and a second food item in the food storage chamber of the drawer.

Abstract: One or more event logs are received. The one or more event logs are analyzed using a plurality of models to detect one or more anomalous events. A graphical representation of risk entities associated with at least one of the one or more detected anomalous events is provided. A visual representation of automatically detected relationships between the risk entities associated with the at least one of the one or more detected anomalous events is provided in the graphical representation. Indications of measures of anomaly associated with detected anomalous events are provided for the associated risk entities.

Abstract: Disclosed are co-polymers which are produced from reactive monomer mixtures and which have both high refractive index and a high Abbe number. These materials are well suited for use as implantable ophthalmic devices and have a refractive index which may be edited through application of energy. When used for an intraocular lens, the high refractive index allows for a thin lens which compresses to allow a small incision size.

Abstract: A tool arrangement for forming a tunnel in a vertebra to perform nerve ablation includes a tamp having a distal end portion that includes a tip for creating the tunnel in the vertebra and a curvable portion to direct the tip along a curved path within the vertebra; a first cannula including a cannula body that is straight along an entire length of the cannula body and configured to receive the curvable portion of the tamp and straighten the curvable portion; and a tool hub including a stationary cannula attachment coupled to the first cannula and a movable head coupled to the tamp and configured to move toward or away from the stationary cannula attachment to extend or retract, respectively, the curvable portion of the tamp from or into, respectively, the first cannula.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: One or more techniques and/or systems are disclosed for a universal-type pump casing that allows for coupling to various piping couplers, for various sizes of fluid lines. This can allow the pump casing to accept the majority of current fluid line coupling, for various fluid line sizes used with these types of pumps, thereby eliminating the need to have a different casing for each different sized fluid line. A universal-type pump casing with a proximal end engaged with a pump bracket, and a distal end affixed to an end plate to define the pumping chamber. A first and second port can have an opening of a predetermined diameter, with a port face that can couple with various modular port flanges, to provide different port flange configurations.

Abstract: One or more techniques and/or systems are disclosed for an improved barrier seal for use on a rotating shaft of a pump to mitigate leakage of fluids along the shaft. The body of the barrier seal may comprise a one-piece combined bushing and seal that can be selectably fastened to the pump bracket. Internal and external channels in the body can operably hold gaskets, internally dynamic seals, and externally static seals, inside the stuffing box of the pump bracket. A lubricant port can be disposed on a flange of the seal portion to provide lubricant to the interior of the barrier seal, which can also be fluidly coupled with the outside of the seal. A pressurized lubricating fluid can also help mitigate leakage of pumped fluid by pressurizing between static gaskets on the outside, and provide lubrication for the rotating shaft on the inside of the seal.

Abstract: One or more techniques and/or systems are disclosed for a universal-type bracket that incorporates a substantially uniform diameter through-bore. This allows the bracket to accept current sealing arrangements used in these types of pumps, while providing the same or better sealing options as current individual designs. The single through-bore can have multiple undercut features for holding a pump shaft bushing, with an increased wall thickness to allow for an appropriate interference fit with the walls of the through-bore, for example, similar to previous designs. Retaining ring grooves can be added to the through-bore, and retaining rings may be used to provide a positive shoulder for the seal or packing rings to seat against inside the bore. This may allow for various sealing options, such as stuffing seals, one-piece barrier seals, cartridge seals, BTR seals, component seals, and more.

Abstract: A mechanical assembly to precisely position large objects and align them to be joined with other objects with precision. The assembly does not require power to operate and can therefore be used in a variety of remote and harsh locations.

Abstract: A powered device may include an engine, a mobility assembly operably coupled to the engine to provide mobility of the powered device responsive at least in part to operation of the engine, a working assembly operably coupled to the engine to perform a working function responsive at least in part to operation of the engine, and a key-operated combination ignition and speed control assembly including switch circuitry configured to control both starting the engine and selection of different selectable positions corresponding to respective different operating speeds for the engine.

Abstract: Cooling medium circulation systems for supplying a cooling medium through a single header to multiplexed heat exchangers are described. In an aspect, a system includes, but is not limited to, a storage tank configured to hold a cooling medium in a fluid state; first and second circulation pumps fluidically coupled to the storage tank; a single cooling medium header fluidically coupled with each of the circulation pumps; a first dryer module configured to direct a first portion of cooling medium from the single cooling medium header past a first stream of compressed air and to direct the first portion of cooling medium back to the storage tank; and a second dryer module fluidically configured to direct a second portion of cooling medium from the single cooling medium header past a second stream of compressed air.

Abstract: The present disclosure relates to a novel, engineered enveloped vector that can be used for gene delivery. The engineered enveloped vector comprises an engineered envelope comprising: (a) a viral envelope protein and optionally, (b) a non-viral membrane-bound protein. The present disclosure also provides a method of making and using the engineered enveloped vector.

Abstract: A viscous food product dispensing system having a transport section for receiving a particulate food product from a bin, an auger for processing and conveying the received particulate food product from the transport section into an outlet adapter via one or more flutes, a milling device housed in the outlet adapter, and a discharge nozzle in the outlet adapter that pinches off the viscous food product created by the milling device. The auger has a unique design that allows it to engage and break whole nuts.

Abstract: A system is disclosed which provides the ability to install a cross arm on a power pole utilizing an electrically isolated bucket which is free of all hydraulic components used by an operator in the bucket to manipulate the bucket. The system also utilizes an in-the-bucket rechargeable battery powered electric tool such as a saw, drill etc. without a need for a hydraulic electric generator in the bucket. The system includes the ability to provide communication to and from and to supply electrical power to remote portions of an electrically isolated boom, by transmitting optical power and control signals through an electrically non-conductive optical fiber.

Abstract: The present invention relates to immunogenic compositions comprising recombinantly constructed polypeptides useful for preparing vaccines, in particular for reducing one or more clinical signs caused by a rotavirus infection. More particular, the present invention is directed to an immunogenic composition containing (i) a fusion protein comprising in N- to C-terminal direction (A) an immunogenic fragment of a rotavirus VP8 protein and (B) an immunoglobulin Fc fragment such as, for example, an IgG Fc fragment, and (ii) an immunogenic substance, different from said fusion protein, wherein said immunogenic composition is usable in a method of reducing one or more clinical signs, mortality or fecal shedding caused by a rotavirus infection in swine.

Abstract: One or more event logs are received. The one or more event logs are analyzed using a plurality of models to detect one or more anomalous events. A graphical representation of risk entities associated with at least one of the one or more detected anomalous events is provided. A visual representation of automatically detected relationships between the risk entities associated with the at least one of the one or more detected anomalous events is provided in the graphical representation. Indications of measures of anomaly associated with detected anomalous events are provided for the associated risk entities.

Abstract: The present invention relates generally to a recombinant protein, compositions comprising such recombinant protein, and to methods for producing such recombinant protein and compositions.

Abstract: A new cultivar of Daphne plant named ‘Moon Canyon’ that is characterized by its open and semi-upright plant habit, striking variegated green-centered and yellow-margined foliage in spring and cream-yellow margins from late spring and early summer, and white flowers whose orange anthers present as small orange eyes. Plants of ‘Moon Canyon’ are in continual bloom from late spring until fall, with peak blooming occurring in late spring and early summer. In combination, these traits set ‘Moon Canyon’ apart from all other varieties of Daphne known to the inventor.