Patents by Inventor Scott A. McLuckey
Scott A. McLuckey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8927295Abstract: An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.Type: GrantFiled: September 2, 2010Date of Patent: January 6, 2015Assignee: Purdue Research FoundationInventors: Kerry M. Hassell, Scott A. McLuckey, Yves Leblanc
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Publication number: 20140145095Abstract: A method of operating a quadrupole mass spectrometer is described where one of the stages thereof has a pairs of opposing rods and one of the pair of rods is operated with a zero voltage potential difference therebetween and the other of the pair of opposing rods is operated with a voltage potential difference therebetween. The potential field unbalance causes the analyte ions to deviate from the axial centerline of the stage so as to undergo additional RF heating. The stage is operated in a transmission mode and the resultant reaction products may be further processed in subsequent stages or output to a mass spectrometer.Type: ApplicationFiled: June 14, 2012Publication date: May 29, 2014Inventors: Scott A. McLuckey, Ian K. Webb
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Patent number: 8598517Abstract: A method and apparatus for radial activation of transmission-mode electron transfer ion/ion reactions using a dipolar AC field applied transverse to a transit direction is disclosed. Increases in fragment ion yields and structural information from electron transfer dissociation (ETD) were observed. The method may be used for transmission mode ETD for relatively low charge states of peptides and proteins.Type: GrantFiled: December 17, 2008Date of Patent: December 3, 2013Assignee: Purdue Research FoundationInventors: Scott A. McLuckey, Yu Xia, Hongling Han
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Patent number: 8334503Abstract: A method of controlling ion parking in an ion trap includes generating a trapping field for trapping cations and anions, and applying a tailored waveform during a period when ion/ion reactions occur to park first generation product ions with m/z values that differ from those of a cation and an anion in selected m/z regions. In particular, the tailored waveform inhibits simultaneously the reactions of ions of disparate m/z ratios.Type: GrantFiled: May 1, 2006Date of Patent: December 18, 2012Assignee: Purdue Research FoundationInventors: Scott A. Mcluckey, Paul A. Chrisman, Sharon J. Pitteri
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Publication number: 20100314537Abstract: A method and apparatus for radial activation of transmission-mode electron transfer ion/ion reactions using a dipolar AC field applied transverse to a transit direction is disclosed. Increases in fragment ion yields and structural information from electron transfer dissociation (ETD) were observed. The method may be used for transmission mode ETD for relatively low charge states of peptides and proteins.Type: ApplicationFiled: December 17, 2008Publication date: December 16, 2010Inventors: Scott A. McLuckey, Yu Xia, Hongling Han
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Patent number: 7842917Abstract: A method an apparatus for analyzing biomolecules is described. The method includes injecting and storing one species of ionized molecule in a linear ion trap and injecting second species of oppositely polarity ionized molecule such that the second species is transmitted through the stored first species. The resultant reaction products may be analyzed by a mass analyzed taking account of the remaining charge values. In an aspect, a linear ion trap may be used as the reaction volume, and the ionized species injected along the axis of the trap in a substantially collinear manner. The mass analysis may be performed by mass selective axial ejection or by a mass spectrometer.Type: GrantFiled: November 29, 2007Date of Patent: November 30, 2010Assignee: Purdue Research FoundationInventors: Scott A. McLuckey, Xiaorong Liang, Yu Xia
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Patent number: 7829851Abstract: A method and apparatus for identification of activating ions by collisions is described. The method uses a plurality of linear ion taps and a plurality of sources of ions and a mass measuring device. A first source is operated to dispense first ions into first trap, where the ions may be kinetically cooled. A second source is operated to dispense second ions into the first trap, where the first and the second ions are stored. Ions in the first trap are ejected so as to enter a second trap, where the ions are stored prior to mass spectrometry. The apparatus may use quadrupole rods to form the ion traps, and the voltage and pressure differences between the first and second traps are controllable values.Type: GrantFiled: November 29, 2007Date of Patent: November 9, 2010Assignee: Purdue Research FoundationInventors: Scott A. McLuckey, Hongling Han, Yu Xia
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Publication number: 20100084548Abstract: A method of controlling ion parking in an ion trap includes generating a trapping field for trapping cations and anions, and applying a tailored waveform during a period when ion/ion reactions occur to park first generation product ions with m/z values that differ from those of a cation and an anion in selected m/z regions. In particular, the tailored waveform inhibits simultaneously the reactions of ions of disparate m/z ratios.Type: ApplicationFiled: May 1, 2006Publication date: April 8, 2010Inventors: Scott A. McLuckey, Paul A. Chrisman, Sharon J. Pitteri
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Patent number: 7550718Abstract: Processes and apparatus are described for the analysis of molecules or fragments thereof, which are capable of carrying multiple charges, by reacting the multiply charged molecules or fragments thereof with other ions using mass spectrometry.Type: GrantFiled: May 30, 2003Date of Patent: June 23, 2009Assignee: Purdue Research FoundationInventors: Scott A. McLuckey, Min He
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Publication number: 20080128611Abstract: A method an apparatus for analyzing biomolecules is described. The method includes injecting and storing one species of ionized molecule in a linear ion trap and injecting second species of oppositely polarity ionized molecule such that the second species is transmitted through the stored first species. The resultant reaction products may be analyzed by a mass analyzed taking account of the remaining charge values. In an aspect, a linear ion trap may be used as the reaction volume, and the ionized species injected along the axis of the trap in a substantially collinear manner. The mass analysis may be performed by mass selective axial ejection or by a mass spectrometer.Type: ApplicationFiled: November 29, 2007Publication date: June 5, 2008Inventors: Scott A. McLuckey, Xiaorong Liang, Yu Xia
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Publication number: 20080128610Abstract: A method and apparatus for identification of activating ions by collisions is described. The method uses a plurality of linear ion traps and a plurality of sources of ions and a mass measuring device. A first source is operated to dispense first ions into a first trap, where the ions may be kinetically cooled. A second source is operated to dispense second ions into the first trap, where the first and the second ions are stored. Ions in the first trap are ejected so as to enter a second trap, where the ions are stored prior to mass spectrometry. The apparatus may use quadrupole rods to form the ion traps, and the voltage and pressure differences between the first and second traps are controllable values.Type: ApplicationFiled: November 29, 2007Publication date: June 5, 2008Inventors: Scott A. McLuckey, Hongling Han, Yu Xia
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Patent number: 7355169Abstract: A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.Type: GrantFiled: May 5, 2006Date of Patent: April 8, 2008Assignee: Purdue Research FoundationInventors: Scott A. McLuckey, Gavin E. Reid, James Mitchell Wells
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Patent number: 7064317Abstract: A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.Type: GrantFiled: August 12, 2002Date of Patent: June 20, 2006Assignee: Purdue Research FoundationInventors: Scott A. McLuckey, Gavin E. Reid, James Mitchell Wells
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Publication number: 20040173740Abstract: A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.Type: ApplicationFiled: February 4, 2004Publication date: September 9, 2004Inventors: Scott A. McLuckey, Gavin E. Reid, James Mitchell Wells
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Patent number: 6452168Abstract: A continuous beam Fourier transform mass spectrometer in which a sample of ions to be analyzed is trapped in a trapping field, and the ions in the range of the mass-to-charge ratios to be analyzed are excited at their characteristic frequencies of motion by a continuous excitation signal. The excited ions in resonant motions generate real or image currents continuously which can be detected and processed to provide a mass spectrum.Type: GrantFiled: September 15, 1999Date of Patent: September 17, 2002Assignee: UT-Battelle, LLCInventors: Scott A. McLuckey, Douglas E. Goeringer
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Patent number: 5206509Abstract: A universal collisional activation ion trap comprises an ion trapping means containing a bath gas and having connected thereto a noise signal generator. A method of operating a universal collisional activation ion trap comprises the steps of: providing an ion trapping means; introducing into the ion trapping means a bath gas; and, generating a noise signal within the ion trapping means; introducing into the ion trapping means a substance that, when acted upon by the noise signal, undergoes collisional activation to form product ions.Type: GrantFiled: December 11, 1991Date of Patent: April 27, 1993Assignee: Martin Marietta Energy Systems, Inc.Inventors: Scott A. McLuckey, Douglas E. Goeringer, Gary L. Glish
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Patent number: 4849628Abstract: An atmospheric sampling glow discharge ionization source that can be used in combination with an analytical instrument which operates at high vacuum, such as a mass spectrometer. The atmospheric sampling glow discharge ionization source comprises a chamber with at least one pair of electrodes disposed therein, an inlet for a gaseous sample to be analyzed and an outlet communicating with an analyzer which operates at subatmospheric pressure. The ionization chamber is maintained at a pressure below atmospheric pressure, and a voltage difference is applied across the electrodes to induce a glow discharge between the electrodes, so that molecules passing through the inlet are ionized by the glow discharge and directed into the analyzer. The ionization source accepts the sample under atmospheric pressure conditions and processes it directly into the high vacuum instrument, bridging the pressure gap and drawing off unwanted atmospheric gases.Type: GrantFiled: November 4, 1988Date of Patent: July 18, 1989Assignee: Martin Marietta Energy Systems, Inc.Inventors: Scott A. McLuckey, Gary L. Glish