Abstract: The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.

Abstract: A context-aware voice guidance method is provided that interacts with other voice services of a user device. The voice guidance does not provide audible guidance while the user is making a verbal request to any of the voice-activated services. Instead, the voice guidance transcribes its output on the screen while the verbal requests from the user are received. In some embodiments, the voice guidance only provides a short warning sound to get the user's attention while the user is speaking on a phone call or another voice-activated service is providing audible response to the user's inquires. The voice guidance in some embodiments distinguishes between music that can be ducked and spoken words, for example from an audiobook, that the user wants to pause instead of being skipped. The voice guidance ducks music but pauses spoken words of an audio book in order to provide voice guidance to the user.

Abstract: The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epitope of CTLA-4 (i.e., a “PD-1×CTLA-4 bispecific molecule”). The PD-1×CTLA-4 bispecific molecules of the present invention are capable of simultaneously binding to PD-1 and to CTLA-4, particularly as such molecules are arrayed on the surfaces of human cells. The invention is directed to pharmaceutical compositions that contain such PD-1×CTLA-4 bispecific molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention also pertains to methods of using such PD-1×CTLA-4 bispecific molecules to stimulate an immune response.

Abstract: Examples provide a mobile computing device including a memory storing an interactive presentation application, a user interface, and an electronic processor. The electronic processor is configured to prompt a user to upload a first visual or audio media item, prompt the user to record a first audio recording contextually related to the first media item, link the first audio recording to the first media item, prompt the user to upload a second visual or audio media item, prompt the user to record a second audio recording contextually related to the second media item, link the second audio recording to the second media item, generate a second visual thumbnail representative of the second media item, and generate an interactive multimedia presentation that outputs the first media item and the linked first audio recording followed by the second media item and the linked second audio recording.

Abstract: A system and method including one or more conduits, a pump system, and a controller. The conduits are fluidly coupled with a cooling device that is operably coupled with an engine to cool at least a portion of exhaust from the engine. The pump system pumps a cleaning fluid from a cleaning fluid source through the one or more conduits and into a flow path of a portion of the exhaust from the engine while the engine continues to operate. The controller monitors operation of the engine and determines whether the engine is operating in a designated state. The controller controls the pump system to pump the cleaning fluid into the flow path of a portion the exhaust from the engine to clean the cooling device while the engine operates in the designated state and the exhaust flows from the engine and through the cooling device.

Abstract: Leaching chamber units have an elongated body with a length extending between a closed end and an open end. The closed end of the leaching chamber unit may define one or more fluid flow openings. The elongated body of the leaching chamber unit has an arcuate, arched or convex cross-sectional shape and includes strengthening ribs extending transverse to the length of the elongated body. The strengthening ribs are arranged in a regular, repeating pattern along the length of the elongated body. The repeating pattern and complementary shape of the strengthening ribs allow the disclosed leaching chamber units to be nested for storage and transport.

Abstract: An electronic device, which comprises a display element and a heat-activated adhesive film (HAF). The heat-activated adhesive film may have a planar surface complementary to and in contact with a planar surface of the display element. Another planar surface for the HAF, opposite to the planar surface of the HAF in contact with the planar surface of the display element, is complementary to and in contact with a planar surface of a laminate layer. The HAF becomes adhesive and bonds to both the display element and the laminate by being exposed to a heat source. There may also be a pressure-sensitive adhesive (PSA) layer added to the laminate layer.

Abstract: A perforating gun is disclosed with shaped charges at a preferential orientation. An example includes a gun body and a charge carrier disposed within the gun body. The charge carrier defines a longitudinal carrier axis and has a plurality of axially-spaced charge mounting locations. A plurality of charges are each pivotally mounted to the charge carrier at one of the respective charge mounting locations about a charge pivot axis transverse to the longitudinal carrier axis. The charges may preferentially align in response to gravity so their orientation remains constant throughout a range of inclination of the wellbore.

Abstract: Macromolecule compositions and related methods that effect targeted delivery of therapeutic agents to effector targets in a desired cell, tissue and/or organ of interest while minimizing or avoiding undesirable delivery to other cells, tissues or organs are provided. Compositions and methods related to macromolecules, such as an ANDbody™, that include an effector target binding domain specific for an effector target, and an address binding domain specific for an address target are described.

Abstract: A core sheet includes a primary textured surface and separate secondary cuspations or corrugations. The core sheets are configured for use within a fluid or wastewater treatment unit that typically includes one or more fabric layers. The primary textured surface enhances retention of wastewater fluid received by the unit, which over time causes an increase in build-up of biomatter on the surface, which in turn enhances the efficacy of treatment of the wastewater. An inline process of making the core sheet includes extrusion forming a smooth flat sheet from raw polymeric material and immediately feeding the smooth flat sheet through texturizing rollers, followed by rolling flat textured sheets. Cuspations are added to the flat textured sheets, optionally at a different site, and then cut to preferred dimensions for incorporation into a wastewater unit.

Abstract: The present disclosure relates to systems and methods for tying activity of a user or group in a cloud service with an identity provider (IDP). This intelligence from the cloud service can be used to continuously authenticate a user or group as they are using the cloud service, thus confirming authentication beyond the initial identity (ID) determination or login process. By gathering a baseline for the access of users and groups, it is possible to detect when a user or user device shows anomalous behavior. Responsive to detecting anomalous behavior, the IDP can be notified, and remediation can be quickly initiated with the utilization of security measures such as access denial, account disabling, requiring a user to change a password, and/or other actions of the like. Such security actions may be preset in a playbook built for response to various security risks.

Abstract: A system and method including one or more conduits, a pump system, and a controller. The conduits are fluidly coupled with a cooling device that is operably coupled with an engine to cool at least a portion of exhaust from the engine. The pump system pumps a cleaning fluid from a cleaning fluid source through the one or more conduits and into a flow path of a portion of the exhaust from the engine while the engine continues to operate. The controller monitors operation of the engine and determines whether the engine is operating in a designated state. The controller controls the pump system to pump the cleaning fluid into the flow path of a portion the exhaust from the engine to clean the cooling device while the engine operates in the designated state and the exhaust flows from the engine and through the cooling device.

Abstract: A system is provided that may include plural data collector devices that may be configured to be communicatively coupled with each other in a network. Each of the data collector device may include one or more processors configured to receive display data from one or more data sources. The one or more processors may also be configured to communicate different portions of the display data to different respective network locations in the network. The one or more processors of each of the data collector devices may also be configured to control a respective display device of several display devices to alternate between displaying the different network locations at different times.

Abstract: A system and method operate by, while an engine is operating, automatically determining whether the engine is in a designated state for EGR cooler cleaning. The EGR cooler is operably coupled to the engine to receive hot EGR from an exhaust of the engine and to provide cooled EGR to an intake of the engine. The system and method also include, responsive to the engine not being in the designated state, automatically preventing a water pump system from introducing a cleaning liquid into a gas inlet of the EGR cooler.

Abstract: A method includes monitoring user behavior in an enterprise system, identifying a given user of the enterprise system associated with a given portion of the monitored user behavior, determining a predicted impact of compromise of the given user on the enterprise system, generating a risk score for the given user based on the predicted impact of compromise and the given portion of the monitored user behavior, and identifying one or more remedial actions to reduce the risk score for the given user. The method also includes implementing, prior to detecting compromise of the given user, at least one of the remedial actions to modify a configuration of at least one asset in the enterprise system, the at least one asset comprising at least one of a physical computing resource and a virtual computing resource in the enterprise system.

Abstract: Embodiments of an inflatable transfer device including a top panel, a bottom panel coupled to the top panel to define an inflatable chamber therebetween, and a high-friction surface coupled to the top panel are disclosed. A top edge of each of the stringers is coupled to the top panel and a bottom edge of each of the stringers is coupled to the bottom panel. The high-friction surface is configured to maintain a patient in a fixed position when the inflatable transfer device and the patient are positioned at an angle with respect to a horizontal support surface.

Abstract: IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions.

Abstract: A driver management system and a method of operating the same. The driver management system includes: a monitoring part provided in a vehicle and determining a level of driving attention of a driver; and a vehicle stopping determination part receiving the level of driving attention of the driver, determining vehicle stop frequency at which a vehicle stops at a plurality of vehicle stopping points provided on a road, decreasing the vehicle stop frequency when the level of driving attention is high, and increasing the vehicle stop frequency when the level of driving attention is low.

Abstract: IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions.

Abstract: Methods, systems, and computer-readable media for centralized management of remote endpoint devices are disclosed. Instances of agent software are installed on endpoint devices that are external to a multi-tenant provider network. The agent software is communicatively coupled to a centralized management service of the multi-tenant provider network. A software package is selected from a marketplace service of the multi-tenant provider network. The marketplace service comprises product offerings for a plurality of software packages. The centralized management service sends information indicative of a configuration associated with the software package to the agent software of one or more of the endpoint devices that are associated with the software package. The centralized management service receives, from the agent software, an indication that the configuration has been deployed on the one or more of the endpoint devices.